GR1000850B - Διαλυτα ανθρωπινα τεμαχια cd4 και οι χρησεις τους. - Google Patents
Διαλυτα ανθρωπινα τεμαχια cd4 και οι χρησεις τους.Info
- Publication number
- GR1000850B GR1000850B GR880100675A GR880100675A GR1000850B GR 1000850 B GR1000850 B GR 1000850B GR 880100675 A GR880100675 A GR 880100675A GR 880100675 A GR880100675 A GR 880100675A GR 1000850 B GR1000850 B GR 1000850B
- Authority
- GR
- Greece
- Prior art keywords
- fragments
- soluble human
- uses therefor
- hiv
- grp120
- Prior art date
Links
- 239000012634 fragment Substances 0.000 title abstract 3
- 101100005713 Homo sapiens CD4 gene Proteins 0.000 abstract 1
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 1
- 230000035755 proliferation Effects 0.000 abstract 1
- 230000000069 prophylactic effect Effects 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70514—CD4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Toxicology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- Cell Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10618587A | 1987-10-08 | 1987-10-08 | |
US14431388A | 1988-01-14 | 1988-01-14 | |
US20658588A | 1988-06-14 | 1988-06-14 | |
US07/217,475 US5109123A (en) | 1988-06-14 | 1988-07-11 | Alteration of ability of soluble CD4 fragments to bind HIV |
Publications (1)
Publication Number | Publication Date |
---|---|
GR1000850B true GR1000850B (el) | 1993-02-17 |
Family
ID=27493499
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GR880100675A GR1000850B (el) | 1987-10-08 | 1988-10-07 | Διαλυτα ανθρωπινα τεμαχια cd4 και οι χρησεις τους. |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP0400010A1 (xx) |
JP (1) | JPH03504234A (xx) |
AU (1) | AU2614888A (xx) |
DK (1) | DK87490A (xx) |
ES (1) | ES2012129A6 (xx) |
GR (1) | GR1000850B (xx) |
IL (1) | IL87902A0 (xx) |
NZ (1) | NZ226475A (xx) |
WO (1) | WO1989003222A1 (xx) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5637677A (en) | 1987-07-16 | 1997-06-10 | The Trustees Of The University Of Pennsylvania | Biologically active compounds and methods of constructing and using the same |
ZA887365B (en) * | 1987-10-02 | 1990-05-30 | Genentech Inc | Adheson variants |
AU623924B2 (en) * | 1988-07-22 | 1992-05-28 | United States of America, as represented by the Secretary, U.S. Department of Commerce, The | Cytotoxic agent against specific virus infection |
US5206353A (en) * | 1988-07-23 | 1993-04-27 | The United States Of America As Represented By The Department Of Health And Human Services | CD-4/cytotoxic gene fusions |
EP0408372A1 (en) * | 1989-07-13 | 1991-01-16 | Smithkline Beecham Corporation | Anti-viral therapy |
CA2065010A1 (en) * | 1989-08-23 | 1991-02-24 | Brian Seed | Non-human primate cd4 polypeptides, fusions thereof, dna encoding, and uses thereof |
US5614612A (en) * | 1990-03-09 | 1997-03-25 | Haigwood; Nancy L. | Purified gp120 compositions retaining natural conformation |
JPH0725794B2 (ja) * | 1990-03-23 | 1995-03-22 | 呉羽化学工業株式会社 | 新規なペプチド |
CA2091258A1 (en) * | 1990-09-14 | 1992-03-15 | William Williams | Design of bioactive peptides based on immunoglobulin structure |
US7070991B2 (en) | 1991-02-08 | 2006-07-04 | Progenics Pharmaceuticals, Inc. | Cells expressing a CD4-IgG2 chimeric heterotetramer |
AU1438592A (en) * | 1991-02-08 | 1992-09-07 | Progenics Pharmaceuticals, Inc. | Cd4-gamma1 and cd4-igg1 chimeras |
ATE288923T1 (de) | 1991-02-08 | 2005-02-15 | Progenics Pharm Inc | Cd4-gamma2- und cd4-igg2-chimären |
US5234905A (en) * | 1991-02-22 | 1993-08-10 | University Of Colorado Foundation, Inc. | Soluble CD4 molecules modified to prolong circulating half-life |
EP0510483A1 (en) * | 1991-04-22 | 1992-10-28 | Boehringer Ingelheim Pharmaceuticals Inc. | Method for the detection of viruses |
AU2487300A (en) | 1998-12-31 | 2000-07-31 | Chiron Corporation | Polynucleotides encoding antigenic hiv type c polypeptides, polypeptides and uses thereof |
JP4776075B2 (ja) | 1998-12-31 | 2011-09-21 | ノバルティス バクシンズ アンド ダイアグノスティックス,インコーポレーテッド | 改変hivenvポリペプチド |
US6602705B1 (en) | 1998-12-31 | 2003-08-05 | Chiron Corporation | Expression of HIV polypeptides and production of virus-like particles |
US7935805B1 (en) | 1998-12-31 | 2011-05-03 | Novartis Vaccines & Diagnostics, Inc | Polynucleotides encoding antigenic HIV Type C polypeptides, polypeptides and uses thereof |
US7211659B2 (en) | 2001-07-05 | 2007-05-01 | Chiron Corporation | Polynucleotides encoding antigenic HIV type C polypeptides, polypeptides and uses thereof |
US20030170614A1 (en) | 2001-08-31 | 2003-09-11 | Megede Jan Zur | Polynucleotides encoding antigenic HIV type B polypeptides, polypeptides and uses thereof |
AU2002316578A1 (en) | 2001-08-31 | 2003-03-18 | Chiron Corporation | Polynucleotides encoding antigenic hiv type b polypeptides, polypeptides and uses thereof |
EP2968453B1 (en) | 2013-03-15 | 2019-12-04 | The U.S.A. as represented by the Secretary, Department of Health and Human Services | Stabilized single human cd4 domains and fusion proteins |
WO2017055522A1 (en) | 2015-09-29 | 2017-04-06 | Academisch Medisch Centrum | Stabilized env proteins of hiv |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1988001304A1 (en) * | 1986-08-21 | 1988-02-25 | The Trustees Of Columbia University In The City Of | Dna encoding the t cell surface protein t4 and use of fragments of t4 in the treatment of aids |
EP0314317A1 (en) * | 1987-10-02 | 1989-05-03 | Genentech, Inc. | Adheson variants, nucleic acid encoding them and compositions comprising them |
-
1988
- 1988-10-04 IL IL87902A patent/IL87902A0/xx unknown
- 1988-10-05 EP EP88909683A patent/EP0400010A1/en not_active Withdrawn
- 1988-10-05 WO PCT/US1988/003454 patent/WO1989003222A1/en not_active Application Discontinuation
- 1988-10-05 AU AU26148/88A patent/AU2614888A/en not_active Abandoned
- 1988-10-05 JP JP63508932A patent/JPH03504234A/ja active Pending
- 1988-10-06 NZ NZ226475A patent/NZ226475A/en unknown
- 1988-10-07 GR GR880100675A patent/GR1000850B/el unknown
- 1988-10-07 ES ES8803064A patent/ES2012129A6/es not_active Expired - Lifetime
-
1990
- 1990-04-06 DK DK087490A patent/DK87490A/da not_active Application Discontinuation
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1988001304A1 (en) * | 1986-08-21 | 1988-02-25 | The Trustees Of Columbia University In The City Of | Dna encoding the t cell surface protein t4 and use of fragments of t4 in the treatment of aids |
EP0314317A1 (en) * | 1987-10-02 | 1989-05-03 | Genentech, Inc. | Adheson variants, nucleic acid encoding them and compositions comprising them |
Non-Patent Citations (4)
Title |
---|
CELL, vol. 42, no. 1, August 1985, pages 93-104, MIT; P.J. MADDON et al.: "The isolation and nucleotide sequence of a cDNA encoding the T cell surface protein T4: a new member of the immunoglobulin gene family" * |
CLAIMS SEARCHED: ALL * |
NATIRE, vol. 331, no. 6151, 7th January 1988, pages 76-78, London, GB; R.A. FISHER et al.: "HIV infection is blocked in vitro by recombinant soluble CD4" * |
NATURE, vol. 331, no. 6151, 7th January 1988, pages 78-81, London, GB; R.E. HUSSEY et al.: "A soluble CD4 protein selectively inhibits HIV replication and cyncytium formation" * |
Also Published As
Publication number | Publication date |
---|---|
EP0400010A1 (en) | 1990-12-05 |
AU2614888A (en) | 1989-05-02 |
DK87490A (da) | 1990-06-08 |
ES2012129A6 (es) | 1990-03-01 |
NZ226475A (en) | 1991-03-26 |
IL87902A0 (en) | 1989-03-31 |
WO1989003222A1 (en) | 1989-04-20 |
DK87490D0 (da) | 1990-04-06 |
JPH03504234A (ja) | 1991-09-19 |
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