GB995366A - Imidazolidine derivatives - Google Patents

Imidazolidine derivatives

Info

Publication number
GB995366A
GB995366A GB38683/62A GB3868362A GB995366A GB 995366 A GB995366 A GB 995366A GB 38683/62 A GB38683/62 A GB 38683/62A GB 3868362 A GB3868362 A GB 3868362A GB 995366 A GB995366 A GB 995366A
Authority
GB
United Kingdom
Prior art keywords
group
formula
reacting
compound
halogen atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB38683/62A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of GB995366A publication Critical patent/GB995366A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

The invention comprises compounds of the formula <FORM:0995366/C2/1> wherein R1 is a hydrogen or halogen atom or an alkyl, alkoxy, trifluoromethyl, alkylthio, alkylsulphonyl, alkanoyl, hydroxy or aralkoxy group, R2 and R3 are hydrogen atoms or alkyl, alkenyl, propargyl, cycloalkyl or aralkyl groups or, in combination with the nitrogen atom to which they are attached, a pyrrolidino, alkylpyrrolidino, piperidino, alkylpiperidino, hexamethyleneimino, morpholino, alkylmorpholino, alkylpiperazino, hydroxyalkylpiperazino or alkanoyloxyalkylpiperazino group, Y is oxygen or sulphur, n is 2, 3 or 4, and A and B are hydrogen atoms or alkyl groups, the alkyl groups or moieties alone having 1 to 6 carbon atoms, non-toxic and addition salts thereof, and their preparation by (a) reacting an amine of formula R2R3NCnH2nX, wherein X is a halogen atom or an arylsulphonyloxy group, with a compound of formula <FORM:0995366/C2/2> and, if desired, connecting an alkoxy or aralkoxy group to a hydroxy group, oxidizing an alkylthio group to an alkylsulphonyl group or when Y is oxygen, replacing it by sulphur by treatment with phosphorus pentasulphide; (b) cyclizing one of the compounds of formulae <FORM:0995366/C2/3> (c) reacting a compound of formula <FORM:0995366/C2/4> with ethyl chloroformate, phosgene or ethyl carbonate; or (d) reacting an amine R2R3NH with a compound of formula <FORM:0995366/C2/5> where X is a halogen atom or an arylsulphonyl group. The compounds of the invention have tranquillizing properties and may be used in pharmaceutical compositions in combination with suitable carries in forms suitable for oral administration, e.g. as tablets, capsules or pills.
GB38683/62A 1961-10-24 1962-10-12 Imidazolidine derivatives Expired GB995366A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14720361A 1961-10-24 1961-10-24
US22707862A 1962-09-28 1962-09-28

Publications (1)

Publication Number Publication Date
GB995366A true GB995366A (en) 1965-06-16

Family

ID=26844686

Family Applications (1)

Application Number Title Priority Date Filing Date
GB38683/62A Expired GB995366A (en) 1961-10-24 1962-10-12 Imidazolidine derivatives

Country Status (9)

Country Link
AT (1) AT258282B (en)
BE (1) BE623942A (en)
CH (3) CH455805A (en)
DE (1) DE1445415C3 (en)
DK (2) DK104937C (en)
ES (1) ES281798A1 (en)
GB (1) GB995366A (en)
NL (1) NL284529A (en)
SE (2) SE308723B (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3728355A (en) * 1970-09-21 1973-04-17 Monsanto Co 3-carbocyclic-5,5-dialkyl-2-imidazolidinethiones
US4215119A (en) * 1976-03-09 1980-07-29 Boehringer Ingelheim Gmbh Aminoalkyl-substituted benzimidazolidin-2-ones

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2644833A1 (en) * 1976-10-05 1978-04-20 Boehringer Sohn Ingelheim NEW 1-ARYLOXY-2-HYDROXY-3-ALKYLENE AMINOPROPANES AND METHOD FOR THE PRODUCTION THEREOF

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3728355A (en) * 1970-09-21 1973-04-17 Monsanto Co 3-carbocyclic-5,5-dialkyl-2-imidazolidinethiones
US4215119A (en) * 1976-03-09 1980-07-29 Boehringer Ingelheim Gmbh Aminoalkyl-substituted benzimidazolidin-2-ones
US4271158A (en) * 1976-03-09 1981-06-02 Boehringer Ingelheim Gmbh Vasodilating or antidepressant phenalkanolaminoalkyl-substituted imidazolidinones

Also Published As

Publication number Publication date
CH455805A (en) 1968-05-15
DK104937C (en) 1966-07-25
CH421975A (en) 1966-10-15
DE1445415B2 (en) 1974-01-10
CH428748A (en) 1967-01-31
SE308723B (en) 1969-02-24
ES281798A1 (en) 1963-03-16
DE1445415A1 (en) 1970-06-25
NL284529A (en)
DE1445415C3 (en) 1974-08-01
DK108256C (en) 1967-10-30
BE623942A (en) 1963-04-23
AT258282B (en) 1967-11-10
SE315902B (en) 1969-10-13

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