GB9930616D0 - Activation and inhibition of the immune system - Google Patents

Activation and inhibition of the immune system

Info

Publication number
GB9930616D0
GB9930616D0 GBGB9930616.9A GB9930616A GB9930616D0 GB 9930616 D0 GB9930616 D0 GB 9930616D0 GB 9930616 A GB9930616 A GB 9930616A GB 9930616 D0 GB9930616 D0 GB 9930616D0
Authority
GB
United Kingdom
Prior art keywords
inhibition
inhibitors
activation
immune system
iob
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
GBGB9930616.9A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kennedy Trust for Rheumatology Research
Original Assignee
Mathilda and Terence Kennedy Institute of Rheumatology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mathilda and Terence Kennedy Institute of Rheumatology filed Critical Mathilda and Terence Kennedy Institute of Rheumatology
Priority to GBGB9930616.9A priority Critical patent/GB9930616D0/en
Publication of GB9930616D0 publication Critical patent/GB9930616D0/en
Priority to US10/168,805 priority patent/US7915009B2/en
Priority to DE60038503T priority patent/DE60038503T2/de
Priority to CNB200610051522XA priority patent/CN100563707C/zh
Priority to EP00985660A priority patent/EP1244466B1/en
Priority to NZ519438A priority patent/NZ519438A/en
Priority to PCT/GB2000/004925 priority patent/WO2001047543A2/en
Priority to AT00985660T priority patent/ATE390929T1/de
Priority to CNB008191050A priority patent/CN1254272C/zh
Priority to EP07014428A priority patent/EP1852123A3/en
Priority to AU22062/01A priority patent/AU781496B2/en
Priority to ES00985660T priority patent/ES2302707T3/es
Priority to CA002394880A priority patent/CA2394880A1/en
Priority to JP2001548135A priority patent/JP2003518507A/ja
Priority to US11/987,956 priority patent/US20080124322A1/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07—Tetrapeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/45—Transferases (2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0008—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/19—Dendritic cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/20—Cellular immunotherapy characterised by the effect or the function of the cells
    • A61K40/24—Antigen-presenting cells [APC]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4242—Transcription factors, e.g. SOX or c-MYC
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/022—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from an adenovirus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/06—Uses of viruses as vector in vitro

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Mycology (AREA)
  • Biotechnology (AREA)
  • Rheumatology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Cell Biology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Microbiology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
GBGB9930616.9A 1999-12-24 1999-12-24 Activation and inhibition of the immune system Ceased GB9930616D0 (en)

Priority Applications (15)

Application Number Priority Date Filing Date Title
GBGB9930616.9A GB9930616D0 (en) 1999-12-24 1999-12-24 Activation and inhibition of the immune system
JP2001548135A JP2003518507A (ja) 1999-12-24 2000-12-22 免疫系の活性化および阻害
PCT/GB2000/004925 WO2001047543A2 (en) 1999-12-24 2000-12-22 Activation and inhibition of the immune system
CNB008191050A CN1254272C (zh) 1999-12-24 2000-12-22 免疫系统的激活和抑制
CNB200610051522XA CN100563707C (zh) 1999-12-24 2000-12-22 免疫系统的激活和抑制
EP00985660A EP1244466B1 (en) 1999-12-24 2000-12-22 ACTIVATION OF THE IMMUNE SYSTEM BY AN NF-kappaB INDUCER AND AN ANTIGEN
NZ519438A NZ519438A (en) 1999-12-24 2000-12-22 Activation and inhibition of the immune system
US10/168,805 US7915009B2 (en) 1999-12-24 2000-12-22 Activation and inhibition of the immune system
AT00985660T ATE390929T1 (de) 1999-12-24 2000-12-22 Aktivierung des immunsystems durch einen antigen und einen nf-kappab auslöser
DE60038503T DE60038503T2 (de) 1999-12-24 2000-12-22 AKTIVIERUNG DES IMMUNSYSTEMS DURCH EINEN ANTIGEN UND EINEN NF-kappaB AUSLÖSER
EP07014428A EP1852123A3 (en) 1999-12-24 2000-12-22 Inhibition of the immune system by inhibitors of NF-kappaB
AU22062/01A AU781496B2 (en) 1999-12-24 2000-12-22 Activation and inhibition of the immune system
ES00985660T ES2302707T3 (es) 1999-12-24 2000-12-22 Activacion del sistema inmunitario por un inductor nf-kappa b y un antigeno.
CA002394880A CA2394880A1 (en) 1999-12-24 2000-12-22 Activation and inhibition of the immune system
US11/987,956 US20080124322A1 (en) 1999-12-24 2007-12-06 Activation and inhibition of the immune system

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9930616.9A GB9930616D0 (en) 1999-12-24 1999-12-24 Activation and inhibition of the immune system

Publications (1)

Publication Number Publication Date
GB9930616D0 true GB9930616D0 (en) 2000-02-16

Family

ID=10867023

Family Applications (1)

Application Number Title Priority Date Filing Date
GBGB9930616.9A Ceased GB9930616D0 (en) 1999-12-24 1999-12-24 Activation and inhibition of the immune system

Country Status (12)

Country Link
US (2) US7915009B2 (enExample)
EP (2) EP1852123A3 (enExample)
JP (1) JP2003518507A (enExample)
CN (2) CN100563707C (enExample)
AT (1) ATE390929T1 (enExample)
AU (1) AU781496B2 (enExample)
CA (1) CA2394880A1 (enExample)
DE (1) DE60038503T2 (enExample)
ES (1) ES2302707T3 (enExample)
GB (1) GB9930616D0 (enExample)
NZ (1) NZ519438A (enExample)
WO (1) WO2001047543A2 (enExample)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9930616D0 (en) * 1999-12-24 2000-02-16 Mathilda & Terence Kennedy Ins Activation and inhibition of the immune system
CN100421727C (zh) * 2000-12-22 2008-10-01 玛蒂尔达和特伦斯·肯尼迪风湿病学信托学会 方法
GB0116249D0 (en) * 2001-07-05 2001-08-29 Imp College Innovations Ltd Methods
JP2003055202A (ja) * 2001-08-15 2003-02-26 Hiroyuki Hanai 炎症性腸疾患の予防・治療剤
CN1306964C (zh) * 2002-05-29 2007-03-28 安琪士摩奇株式会社 治疗和预防炎症性疾病的诱饵组合物
AU2002953094A0 (en) * 2002-12-04 2002-12-19 The University Of Queensland Immunomodulating compositions, processes for their production and uses therefor
US20060257380A1 (en) * 2002-09-19 2006-11-16 Inst.Nat. De La Sante Et De La Recherche MED Use of sirnas for gene silencing in antigen presenting cells
EP2933334B1 (en) * 2003-02-18 2019-09-18 Baylor College of Medicine Induced activation in dendritic cells
US20050147608A1 (en) * 2003-05-08 2005-07-07 Beth Israel Deaconess Medical Center, Inc. Novel regulatory mechanisms of NF-kappaB
TWI487535B (zh) 2004-11-30 2015-06-11 Centocor Inc 類鐸受體３（ｔｏｌｌ ｌｉｋｅ ｒｅｃｅｐｔｏｒ３）拮抗劑，方法及用途
CN100418532C (zh) * 2005-06-17 2008-09-17 吕志民 治疗多种疾病的NF-κB化合物抑制剂
WO2007001487A2 (en) * 2005-06-23 2007-01-04 Baylor College Of Medicine Modulation of negative immune regulators and applications for immunotherapy
US20080311552A1 (en) * 2005-09-20 2008-12-18 London Health Sciences Centre Research, Inc. Use of Sirnas in Organ Storage/Reperfusion Solutions
WO2007051164A2 (en) 2005-10-27 2007-05-03 Centocor, Inc. Toll like receptor 3 modulators, methods and uses
CN101240271B (zh) * 2006-08-28 2012-08-29 长春华普生物技术有限公司 Toll样受体调节性寡核苷酸及其用途
CA2702340C (en) * 2006-10-12 2014-12-16 The University Of Queensland Compositions and methods for modulating immune responses
US8691210B2 (en) * 2006-10-19 2014-04-08 David M Spencer Methods and compositions for generating an immune response by inducing CD40 and pattern recognition receptors and adaptors thereof
WO2008080195A1 (en) * 2006-12-29 2008-07-10 The University Of Queensland Compositions and methods for treating or preventing unwanted immune responses
ES2633470T3 (es) 2008-09-22 2017-09-21 Baylor College Of Medicine Métodos y composiciones de generación de una respuesta inmune mediante la inducción de CD40 y adaptadores de receptores de reconocimiento de patrones
WO2011146862A1 (en) 2010-05-21 2011-11-24 Bellicum Pharmaceuticals, Inc. Methods for inducing selective apoptosis
CN103889461B (zh) * 2011-07-18 2016-11-09 肯塔基大学研究基金会 保护细胞免于alu-rna诱导的变性和用于保护细胞的抑制剂
US9434935B2 (en) 2013-03-10 2016-09-06 Bellicum Pharmaceuticals, Inc. Modified caspase polypeptides and uses thereof
KR20150131218A (ko) 2013-03-14 2015-11-24 벨리쿰 파마슈티컬스, 인크. T 세포 증식의 제어 방법
US9913882B2 (en) 2013-06-05 2018-03-13 Bellicum Pharmaceuticals, Inc. Methods for inducing partial apoptosis using caspase polypeptides
JP6876434B2 (ja) * 2013-09-12 2021-05-26 アイカーン スクール オブ メディシン アット マウント サイナイ 蛍光タンパク質に特異的なｔ細胞受容体を有する遺伝子導入動物の作製方法
CN106132423B (zh) 2014-02-14 2020-07-31 贝里坤制药股份有限公司 用诱导型嵌合多肽活化t细胞的方法
US20150342961A1 (en) * 2014-06-03 2015-12-03 Hai-Hui Xue Use of prostaglandin e1 (pge1) and misoprostol for treating chronic myelogenous/myeloid leukemia (cml)
JP6868554B2 (ja) 2014-09-02 2021-05-12 ベリカム ファーマシューティカルズ， インコーポレイテッド ＭｙＤ８８およびＣＤ４０ポリペプチドによるキメラ抗原受容体の共刺激
EP3215522B1 (en) 2014-11-03 2021-12-01 Academisch Ziekenhuis Leiden H.O.D.N. Leids Universitair Medisch Centrum T cell receptors directed against bob1 and uses thereof
KR102656470B1 (ko) 2014-12-10 2024-04-09 리전츠 오브 더 유니버스티 오브 미네소타 질환을 치료하기 위한 유전적으로 변형된 세포, 조직 및 장기
US10420836B2 (en) 2015-10-08 2019-09-24 Emory University Methods of immunizing a subject and compositions related thereto
MA56038B1 (fr) 2019-05-31 2024-11-29 Janssen Pharmaceutica Nv Inhibiteurs à petite molécule de kinase induisant nf-kb

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6410516B1 (en) * 1986-01-09 2002-06-25 President & Fellows Of Harvard College Nuclear factors associated with transcriptional regulation
US5116742A (en) * 1986-12-03 1992-05-26 University Patents, Inc. RNA ribozyme restriction endoribonucleases and methods
US4987071A (en) * 1986-12-03 1991-01-22 University Patents, Inc. RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods
US5168053A (en) * 1989-03-24 1992-12-01 Yale University Cleavage of targeted RNA by RNAase P
US5149796A (en) * 1989-08-31 1992-09-22 City Of Hope Chimeric DNA-RNA catalytic sequences
CA2073045C (en) 1989-11-03 2007-05-22 Malcolm L. Gefter A human t cell reactive feline protein (trfp) isolated from house dust and uses therefor
US5180818A (en) * 1990-03-21 1993-01-19 The University Of Colorado Foundation, Inc. Site specific cleavage of single-stranded dna
WO1992007573A1 (en) 1990-10-31 1992-05-14 Somatix Therapy Corporation Genetic modification of endothelial cells
WO1994024281A1 (en) 1993-04-14 1994-10-27 Immulogic Pharmaceutical Corporation T cell epitopes of the major allergens from dermatophagoides (house dust mite)
CA2105595A1 (en) * 1992-09-23 1994-03-24 Ramaswamy Narayanan Antisense polynucleotides
US5951988A (en) * 1993-03-30 1999-09-14 University Of Saskatchewan Adjuvant formulation with enhanced immunogenic activity, and related compositions and methods
US5405941A (en) * 1993-04-15 1995-04-11 National Jewish Center For Immunology And Respiratory Medicine MEKK protein, capable of phosphorylating MEK
ATE204300T1 (de) 1994-05-13 2001-09-15 Biovation Ltd Zielzellen-bindende chimäre peptide
NZ290089A (en) 1994-07-27 1999-05-28 Queensland Inst Med Res Recombinant polyepitope cytotoxic t lymphocyte (ctl) vaccines
US5597898A (en) * 1995-02-15 1997-01-28 Yale University NF-κB activation regulatory protein, IκB-β
AU6181196A (en) * 1995-06-29 1997-01-30 Mcneil-Ppc, Inc. The combination of topical nasal antihistamines and topical nasal mast cell stabilizers
EP0779361A3 (en) * 1995-12-15 1999-11-10 F. Hoffmann-La Roche Ag Truncated form of inhibitory kappa B protein (1kB), recombinant production and uses thereof
UA71889C2 (uk) * 1996-04-02 2005-01-17 Йєда Рісерч Енд Дівелопмент Ко. Лтд. Модулятори зв'язаного з рецептором tnf фактора (traf), їх одержання та застосування
CA2262006A1 (en) * 1996-07-26 1998-02-05 Sloan-Kettering Institute For Cancer Research Method and reagents for genetic immunization
CA2262906C (en) 1996-08-12 2006-10-31 Celgene Corporation Novel immunotherapeutic agents and their use in the reduction of cytokine levels
WO1998008955A1 (en) * 1996-08-26 1998-03-05 Signal Pharmaceuticals, Inc. Stimulus-inducible i (kappa)b kinase [ikk] signalsome
US5891924A (en) * 1996-09-26 1999-04-06 Research Development Foundation Curcumin (diferuloylmethane) inhibition of NFκB activation
EP0946725B1 (en) * 1996-12-23 2011-01-26 Immunex Corporation Receptor activator of nf-kappa b, receptor is member of tnf receptor superfamily
US6924308B1 (en) * 1997-07-30 2005-08-02 Howard L. Elford Therapeutic process for inhibiting NF-κB
US5952483A (en) * 1997-07-31 1999-09-14 Smithkline Beecham Corporation Human IκB-β
EP0897009A3 (en) * 1997-08-04 1999-06-09 Smithkline Beecham Plc HKABY60 polypeptides
JPH1171278A (ja) * 1997-09-01 1999-03-16 Kanegafuchi Chem Ind Co Ltd 転写因子ＮＦ−κＢ活性化阻害剤
GB9719238D0 (en) 1997-09-11 1997-11-12 Mathilda & Terence Kennedy Ins Viral infection of cells
US6503184B1 (en) * 1997-10-21 2003-01-07 Human Genome Sciences, Inc. Human tumor necrosis factor receptor-like proteins TR11, TR11SV1 and TR11SV2
US5965421A (en) * 1997-11-26 1999-10-12 Human Genome Sciences, Inc. Human IRAK-2
AU2294899A (en) * 1998-02-19 1999-09-06 Peter Bromley Stress promoter control of therapeutic genes in gene therapy: compositions and methods
JP2002513552A (ja) * 1998-05-06 2002-05-14 フラームス・インテルウニフェルシタイル・インスティチュート・フォール・ビオテヒノロヒー ＮＦ−κＢ活性化の新規な阻害剤
HUP0102782A3 (en) * 1998-06-19 2002-12-28 Smithkline Beecham Corp Salycilanilide as inhibitors of transcription factor nf-kb
GB9823897D0 (en) 1998-11-02 1998-12-30 Imp College Innovations Ltd Immunotherapeutic methods and molecules
AU3755800A (en) * 1999-03-15 2000-10-04 Introgen Therapeutics, Inc. Dendritic cells transduced with a wild-type self gene elicit potent antitumor immune responses
GB9930616D0 (en) 1999-12-24 2000-02-16 Mathilda & Terence Kennedy Ins Activation and inhibition of the immune system
GB0005345D0 (en) * 2000-03-06 2000-04-26 Mathilda & Terence Kennedy Ins Methods of treating sepsis septic shock and inflammation
CN100421727C (zh) * 2000-12-22 2008-10-01 玛蒂尔达和特伦斯·肯尼迪风湿病学信托学会 方法
GB0116249D0 (en) * 2001-07-05 2001-08-29 Imp College Innovations Ltd Methods

Also Published As

Publication number Publication date
CN1817367A (zh) 2006-08-16
CA2394880A1 (en) 2001-07-05
AU781496B2 (en) 2005-05-26
DE60038503T2 (de) 2009-04-30
US20080124322A1 (en) 2008-05-29
EP1852123A3 (en) 2008-09-10
ES2302707T3 (es) 2008-08-01
DE60038503D1 (de) 2008-05-15
CN1434718A (zh) 2003-08-06
CN1254272C (zh) 2006-05-03
JP2003518507A (ja) 2003-06-10
US20030153518A1 (en) 2003-08-14
NZ519438A (en) 2004-03-26
EP1244466B1 (en) 2008-04-02
ATE390929T1 (de) 2008-04-15
AU2206201A (en) 2001-07-09
EP1244466A2 (en) 2002-10-02
WO2001047543A3 (en) 2002-01-17
WO2001047543A2 (en) 2001-07-05
US7915009B2 (en) 2011-03-29
EP1852123A2 (en) 2007-11-07
CN100563707C (zh) 2009-12-02

Similar Documents

Publication Publication Date Title
GB9930616D0 (en) Activation and inhibition of the immune system
AU4932199A (en) Cancer antigens based on tumor suppressor gene wt1 product
YU84303A (sh) Postupak dobijanja cetp inhibitora
AU6114700A (en) Novel system for the sequential, directional cloning of multiple dna sequences
WO2000049158A3 (en) Psa and klk-2 splicing variants
CA2361987A1 (en) Goodpasture antigen binding protein
WO2000009693A3 (en) Identification of the gene causing the mouse scurfy phenotype and its human ortholog
HUT74273A (en) Grb3-3 gene, variants and uses thereof
WO2001088124A3 (en) Method and reagent for the inhibition of erg
AU4300497A (en) Process for the manufacture of aliphatic alpha, omega amino nitriles
AU1727597A (en) Purified sr-p70 protein
ZA989705B (en) Epoxide hydrolase
DE69526087D1 (de) Or-1, ein wais-rezeptor der nuklearen rezeptoren familie
TWI256720B (en) Semiconductor wafer identification
BG103319A (en) Method for the preparation of hydroxamic acids
NZ511166A (en) Genes that increase the production of HMG-CoA reductase inhibitor, ML-236B
WO2002083727A3 (de) Nukleinsäuresequenzen von hyperplasien und tumoren der schilddrüse
WO1999055874A3 (en) Nucleic acids of the m antigen gene of histoplasma capsulatum, antigens, vaccines and antibodies, methods and kits for detecting histoplasmosis
WO2002036780A3 (en) Stearoyl-coa desaturase gene promoter
WO2002046378A3 (en) Alternative pol k nucleotide and amino acid sequence and methods for using
MX9204348A (es) Vector de adn para la transformacion de celulas de bacillus thuringiensis.
AU4496196A (en) Recombinant DNA comprising DNA coding for myosin heavy chain SM1 isoform protein inserted into vector DNA, microorganism carrying the recombinant DNA, and an agent for treatment of arteriosclerosis comprising the recombinant DNA
WO2003057835A3 (en) Pak5-related compositions and methods
IL142664A0 (en) Prv-1 gene, processes for detecting the prv-1 polypeptide and pharmaceutical compositions containing the same
AU2002221909A1 (en) Method and kit for the direct identification of nucleotide sequences, amino acid sequences or antigens

Legal Events

Date Code Title Description
AT Applications terminated before publication under section 16(1)