GB988065A - Isolation of 6-aminopenicillanic acid - Google Patents

Isolation of 6-aminopenicillanic acid

Info

Publication number
GB988065A
GB988065A GB27246/62A GB2724662A GB988065A GB 988065 A GB988065 A GB 988065A GB 27246/62 A GB27246/62 A GB 27246/62A GB 2724662 A GB2724662 A GB 2724662A GB 988065 A GB988065 A GB 988065A
Authority
GB
United Kingdom
Prior art keywords
acid
eluate
aminopenicillanic acid
resin
aminopenicillanic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB27246/62A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of GB988065A publication Critical patent/GB988065A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
    • C12P37/06—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin by desacylation of the substituent in the 6 position
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J47/00—Ion-exchange processes in general; Apparatus therefor
    • B01J47/014—Ion-exchange processes in general; Apparatus therefor in which the adsorbent properties of the ion-exchanger are involved, e.g. recovery of proteins or other high-molecular compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

6-Aminopenicillanic acid is recovered from impure aqueous solutions thereof by contacting such a solution with a particulate styrenedivinylbenzene-sulphoni acid cation-exchange resin in the acid form, separating the resin with adsorbed 6-aminopenicillanic acid from the aqueous solution, contacting the resin adsorbate with an aqueous alkaline eluting solution having a pH from 8 to 9 and recovering the 6-aminopenicillanic acid from the resin eluate, e.g. by passing the eluate through an ion-exchange resin of the quaternary ammonium type to preferentially adsorb the 6-aminopenicillanic acid and eluting the adsorbed 6-aminopenicillanic acid therefrom with a dilute acid, or by concentrating the eluate and adjusting the pH of the concentrated eluate to about 4.3 to crystallize substantially pure 6-amino-penicillanic acid. Reference has been directed by the Comptroller to Specification 870,396.
GB27246/62A 1961-08-03 1962-07-16 Isolation of 6-aminopenicillanic acid Expired GB988065A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12898161A 1961-08-03 1961-08-03

Publications (1)

Publication Number Publication Date
GB988065A true GB988065A (en) 1965-04-07

Family

ID=22437915

Family Applications (1)

Application Number Title Priority Date Filing Date
GB27246/62A Expired GB988065A (en) 1961-08-03 1962-07-16 Isolation of 6-aminopenicillanic acid

Country Status (4)

Country Link
BR (1) BR6241629D0 (en)
DE (1) DE1225342B (en)
GB (1) GB988065A (en)
NL (1) NL281647A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4113941A (en) 1975-06-26 1978-09-12 Bayer Aktiengesellschaft Process for purifying products obtained from enzymatic cleavage of beta-lactam antibiotics

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE569728A (en) *
DE1075799B (en) * 1960-02-18 Beecham Research Laboratories Limited, Betchworth Surrey (Großbntan men) Process for the production of 6-aminopenicillanic acid
FR1256281A (en) * 1960-04-30 1961-03-17 Process for the preparation of 6-amino-penicillanic acid

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4113941A (en) 1975-06-26 1978-09-12 Bayer Aktiengesellschaft Process for purifying products obtained from enzymatic cleavage of beta-lactam antibiotics

Also Published As

Publication number Publication date
DE1225342B (en) 1966-09-22
NL281647A (en)
BR6241629D0 (en) 1973-05-24

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