GB980387A - 5,6-dihydro-2(1h)-pyrazinones and preparation thereof - Google Patents

5,6-dihydro-2(1h)-pyrazinones and preparation thereof

Info

Publication number
GB980387A
GB980387A GB2809/62A GB280962A GB980387A GB 980387 A GB980387 A GB 980387A GB 2809/62 A GB2809/62 A GB 2809/62A GB 280962 A GB280962 A GB 280962A GB 980387 A GB980387 A GB 980387A
Authority
GB
United Kingdom
Prior art keywords
phenyl
alkyl
formula
group
acid addition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2809/62A
Inventor
Albert Anthony Carr
Charles Harmon Tilford
William Lloyd Kuhn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Richardson Vicks Inc
Original Assignee
Richardson Merrell Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US59825A priority Critical patent/US3056784A/en
Application filed by Richardson Merrell Inc filed Critical Richardson Merrell Inc
Priority to GB2809/62A priority patent/GB980387A/en
Priority to FR887316A priority patent/FR2016M/en
Priority to DER32063A priority patent/DE1197089B/en
Publication of GB980387A publication Critical patent/GB980387A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
    • C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C07D241/40—Benzopyrazines
    • C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention comprises compounds of the general formula <FORM:0980387/C2/1> (in which R1, R2, R3, R4 and R5\t represent hydrogen atoms or C1- 4 alkyl, phenyl or phenethyl groups, or R3 and R4 together represent a tetramethylene group, and R6 represents a C1- 4 alkyl, phenyl, halophenyl, trifluoromethylphenyl, (C1- 4 alkyl)phenyl, (C1- 4 alkoxy)phenyl, dialkoxyphenyl, hydroxy-methoxyphenyl, dialkylaminophenyl, naphthyl, thienyl, indolyl or pyridyl group) and acid addition salts thereof, their preparation by (a) condensing a diamine of the formula NHR1CR2R3CR4R5NH2 with an a -keto ester of the formula R7OOC.COR6 (in which R7 represents a C1- 4 alkyl group), followed by ring closure, or (b)-in cases where R1 is a C1- 4 alkyl group-reacting the corresponding compound in which R1 is a hydrogen atom with a C1- 4 alkylating agent in the presence of an alkali metal hydride, optionally followed in either case by acid addition salt formation, and pharmaceutical preparations containing them. The compounds of the invention are analgesics and may be administered orally or parenterally in the form of pharmaceutical preparations (e.g. capsules, tablets and elixirs) containing them.
GB2809/62A 1960-10-03 1962-01-25 5,6-dihydro-2(1h)-pyrazinones and preparation thereof Expired GB980387A (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US59825A US3056784A (en) 1960-10-03 1960-10-03 Substituted 5, 6-dihydro-2(1h)-pyrazinones
GB2809/62A GB980387A (en) 1962-01-25 1962-01-25 5,6-dihydro-2(1h)-pyrazinones and preparation thereof
FR887316A FR2016M (en) 1962-01-25 1962-02-08 Therapeutic agents belonging to the group of dihydropyrazinones.
DER32063A DE1197089B (en) 1962-01-25 1962-02-08 Process for the preparation of 2-oxo-1, 2, 5, 6-tetrahydropyrazines

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2809/62A GB980387A (en) 1962-01-25 1962-01-25 5,6-dihydro-2(1h)-pyrazinones and preparation thereof

Publications (1)

Publication Number Publication Date
GB980387A true GB980387A (en) 1965-01-13

Family

ID=9746331

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2809/62A Expired GB980387A (en) 1960-10-03 1962-01-25 5,6-dihydro-2(1h)-pyrazinones and preparation thereof

Country Status (2)

Country Link
FR (1) FR2016M (en)
GB (1) GB980387A (en)

Also Published As

Publication number Publication date
FR2016M (en) 1963-09-16

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