GB993746A - Pyridinealdoxime-1-oxide derivatives - Google Patents

Pyridinealdoxime-1-oxide derivatives

Info

Publication number
GB993746A
GB993746A GB20597/62A GB2059762A GB993746A GB 993746 A GB993746 A GB 993746A GB 20597/62 A GB20597/62 A GB 20597/62A GB 2059762 A GB2059762 A GB 2059762A GB 993746 A GB993746 A GB 993746A
Authority
GB
United Kingdom
Prior art keywords
agents
acid addition
tranquillizers
anticonvulsants
analgesics
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB20597/62A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dr F Raschig GmbH
Original Assignee
Dr F Raschig GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr F Raschig GmbH filed Critical Dr F Raschig GmbH
Publication of GB993746A publication Critical patent/GB993746A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/53—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

The invention comprises compounds of the general formula <FORM:0993746/C2/1> (wherein R is a C1-12 hydrocarbon group and R1 is a hydrogen atom or a methyl group) and acid addition salts thereof, and their preparation by (a) reacting a compound of the formula <FORM:0993746/C2/2> with a peroxidizing agent, or (b) reacting the corresponding pyridinecarboxaldehyde 1-oxide with H2NOR, optionally followed in either case by acid addition salt formation. The starting materials for process (a) may be prepared by reacting the corresponding pyridinecarboxaldehyde with H2NOR or by etherification of the parent oxime. The compounds of the invention are antiinflammatory agents, analgesics, anticonvulsants, muscle relaxants, tranquillizers and antipyretic agents, and also potentiate other drugs (see Division A5).ALSO:Pharmaceutical compositions comprise a compound of the general formula (I) <FORM:0993746/A5-A6/1> (wherein R is a C1-12 hydrocarbon group and R1 is a hydrogen atom or a methyl group), or an acid addition salt thereof, and a carrier. The compositions may be administered orally or parenterally in the form of tablets, capsules, pills, granules, powders, wafers, cachets, solutions, suspensions and emulsions, and optionally may contain one or more other active ingredients (e.g. tranquillizers, psychic energizers, sedatives, hypotensive agents, analgesics, antispasmodics, anticonvulsants, anti - arthritic agents and muscle relaxants). The compounds of the general formula (I) and their acid addition salts are anti-inflammatory agents, analgesics, anticonvulsants, muscle relaxants, tranquillizers and antipyretic agents, and also potentiate other drugs.
GB20597/62A 1961-06-30 1962-05-29 Pyridinealdoxime-1-oxide derivatives Expired GB993746A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12094061A 1961-06-30 1961-06-30

Publications (1)

Publication Number Publication Date
GB993746A true GB993746A (en) 1965-06-02

Family

ID=22393389

Family Applications (1)

Application Number Title Priority Date Filing Date
GB20597/62A Expired GB993746A (en) 1961-06-30 1962-05-29 Pyridinealdoxime-1-oxide derivatives

Country Status (2)

Country Link
CH (1) CH417590A (en)
GB (1) GB993746A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4327213A (en) 1977-01-07 1982-04-27 ACF Chemiefarma VA Alpha-hydrocarbonoxyimino-pyrazineacetonitriles

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4327213A (en) 1977-01-07 1982-04-27 ACF Chemiefarma VA Alpha-hydrocarbonoxyimino-pyrazineacetonitriles

Also Published As

Publication number Publication date
CH417590A (en) 1966-07-31

Similar Documents

Publication Publication Date Title
JPS5632440A (en) Propenylamines* their manufacture* pharmaceutic composition containing them and their use as medicine
GB1102934A (en) A process for the manufacture of benzdiaz[1,4]epine derivatives
ES453161A1 (en) Spiro (1,3-dioxolane-4,3{40 ) quinuclidine compounds
GB993746A (en) Pyridinealdoxime-1-oxide derivatives
GB1108577A (en) Improved sulfonanilides and process for preparing the same
GB1104145A (en) Pyrazolo-pyridine derivatives
IL43063A (en) 2-phenoxy-1-imidazolyl-alkan-3-ones their production and pharmaceutical compositions containing them
GB1025697A (en) 4-(2-hydroxyphenyl)-pyrazoles and isoxazoles
ES466192A1 (en) Isoquinoline derivatives and pharmaceutical compositions containing them
GB1055221A (en) Pyridobenzoxazepine derivatives
ATE40948T1 (en) PYRIDYL ALKYL NITRATE COMPOUND, PROCESS FOR ITS PREPARATION AND PHARMACEUTICAL COMPOSITION CONTAINING IT.
ES311285A1 (en) í -1,2,4-triazolone-(5) derivatives
JPS5536453A (en) Novel immunosuppressive agent
GB1023203A (en) Propylamine derivatives
GB1035450A (en) Iminodibenzyl derivatives and a process for the manufacture of same
GB1527483A (en) 2-aminomethyl-5-phenyloxazoles and the pharmaceutically acceptable acid addition salts thereof
GB1025577A (en) Benzdiaz[1,4]epine derivatives and the manufacture thereof
JPS5536454A (en) Novel immunosuppressive agent
GB890829A (en) Novel hydrazones and salts thereof and a process for the manufacture of same
GB1025902A (en) N-alkenylmelamine 5-oxides and pharmaceutical compositions containing them
GB969027A (en) Tetrahydrodibenzazocines
GB1015030A (en) Anorexagenic compositions
GB1097277A (en) Improvements in or relating to organic sulfamoyl compounds
GB980387A (en) 5,6-dihydro-2(1h)-pyrazinones and preparation thereof
GB1027967A (en) Organic nitrates having pharmacological activity