GB1025902A - N-alkenylmelamine 5-oxides and pharmaceutical compositions containing them - Google Patents

N-alkenylmelamine 5-oxides and pharmaceutical compositions containing them

Info

Publication number
GB1025902A
GB1025902A GB364363A GB364363A GB1025902A GB 1025902 A GB1025902 A GB 1025902A GB 364363 A GB364363 A GB 364363A GB 364363 A GB364363 A GB 364363A GB 1025902 A GB1025902 A GB 1025902A
Authority
GB
United Kingdom
Prior art keywords
alkenyl group
group
formula
triazine
chloro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB364363A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of GB1025902A publication Critical patent/GB1025902A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
    • A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention comprises compounds of the formula <FORM:1025902/C2/1> wherein R is a C2- 8 alkenyl group and R1 is H, a C2- 8 alkenyl group or a C1- 8 alkyl group and the preparation thereof by oxidizing the corresponding free base with a perbenzoic acid of the formula <FORM:1025902/C2/2> where n is 0 or an integer from 1 to 5 and X is a halogen atom, a C1- 8 alkyl or alkoxy group or a nitro group. N2, N2, N4-Triallylmelamine is prepared from 2-amino-4-chloro-6-dialcylamino-1,3,5-triazine and allylamine. Similarly is prepared N2-Allylmelamine from 2,4-diamino-6-chloro-1,3,5-triazine.ALSO:Hypotensive compositions comprise compounds of the formula <FORM:1025902/A5-A6/1> wherein R is a C2-8 alkenyl group and R1 is H, a C2-8 alkenyl group or a C1-8 alkyl group, in unit dosage form, containing 1-350 mg of active ingredient per dosage unit, in association with a pharmaceutical carrier. The composition may also include known diuretics, sympathetic blocking agents, ganglion blocking agents, reserpine type drugs, tranquillisers, sedatives, muscle relaxants, antihistamines or other hypotensive agents. Examples are given of the preparation of tablets, capsules, and solutions for oral or parenteral administration.
GB364363A 1962-02-08 1963-01-29 N-alkenylmelamine 5-oxides and pharmaceutical compositions containing them Expired GB1025902A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17183262A 1962-02-08 1962-02-08
US21754262A 1962-08-17 1962-08-17

Publications (1)

Publication Number Publication Date
GB1025902A true GB1025902A (en) 1966-04-14

Family

ID=26867481

Family Applications (1)

Application Number Title Priority Date Filing Date
GB364363A Expired GB1025902A (en) 1962-02-08 1963-01-29 N-alkenylmelamine 5-oxides and pharmaceutical compositions containing them

Country Status (1)

Country Link
GB (1) GB1025902A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4276417A (en) 1978-07-31 1981-06-30 Hoffmann-La Roche Inc. Oxadiazolotriazine derivatives
US4576945A (en) * 1982-10-26 1986-03-18 Sanders Mark E Hexaalkylmelamine-amino-oxy compounds

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4276417A (en) 1978-07-31 1981-06-30 Hoffmann-La Roche Inc. Oxadiazolotriazine derivatives
US4576945A (en) * 1982-10-26 1986-03-18 Sanders Mark E Hexaalkylmelamine-amino-oxy compounds

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