GB975594A - Substituted octalinones and tetrahydro-indanones of use as intermediates in steroid synthesis - Google Patents
Substituted octalinones and tetrahydro-indanones of use as intermediates in steroid synthesisInfo
- Publication number
- GB975594A GB975594A GB40557/60A GB4055760A GB975594A GB 975594 A GB975594 A GB 975594A GB 40557/60 A GB40557/60 A GB 40557/60A GB 4055760 A GB4055760 A GB 4055760A GB 975594 A GB975594 A GB 975594A
- Authority
- GB
- United Kingdom
- Prior art keywords
- carbonyl
- hydroxymethylene
- compounds
- substituted
- methylene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/65—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by splitting-off hydrogen atoms or functional groups; by hydrogenolysis of functional groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/69—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by addition to carbon-to-carbon double or triple bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
- C07C45/73—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups combined with hydrogenation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/385—Saturated compounds containing a keto group being part of a ring
- C07C49/395—Saturated compounds containing a keto group being part of a ring of a five-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/657—Unsaturated compounds containing a keto groups being part of a ring containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
- C07C49/747—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
Abstract
975,594. Substituted octalinones and tetrahydroindanones. H. SMITH. Dec. 20, 1960 [Sept. 25, 1959(2); Feb. 19, 1960], Nos. 40557/60, 40558/60 and 40559/60. Divided out of 975,593. Heading C2C. The invention comprises compounds of formula wherein Ar is phenyl which may be substituted in the m-position with hydroxy, alkoxy, acyloxy, nitro, amino, acylamino or alkylamino as sole substituent, each R is H or alkyl, R <SP>1</SP> is alkyl, Q is methylene or ethylene, and Y is carbonyl, ketalised carbonyl, hydroxymethylene or acyloxymethylene. The compounds and those in which Ar is more generally phenyl having an unsubstituted ortho-position may be prepared by one of the following methods: (a) (Y=carbonyl) cyclodehydration of a compound of formula (b) (Y=carbonyl) condensation of a compound ArCR 2 CR 2 X (X=Cl, Br or organic sulphonyloxy) with a metal enolate of a ketone of structure. (c) (Y=hydroxymethylene) selective reduction of the corresponding compound wherein Y is carbonyl and (d) (Y=ketalised carbonyl or acyloxymethylene) respectively ketalising or esterifying the corresponding compound wherein Y is carbonyl or hydroxymethylene. In examples, the preparation is described of compounds wherein (1)-(12) Ar is phenyl or m-methoxyphenyl, R<SP>1</SP> is methyl, Y is carbonyl, hydroxymethylene or ethylenedioxymethylene and Q is methylene or ethylene; (13), (14), (16), (17) Ar is m-nitro- or m-aminophenyl, R <SP>1</SP> is methyl, Y is carbonyl or hydroxymethylene and Q is methylene, the amino compounds being obtained by reduction of corresponding nitro compounds; (15), (18) Ar is m-acetaminophenyl, R<SP>1</SP> is methyl, Y is carbonyl or acetoxymethylene by acetylation of the appropriate amino precursors. Specifications 975,591, 975,592, 975,595 and 975,596 also are referred to.
Priority Applications (17)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB32620/59A GB975593A (en) | 1959-09-25 | 1959-09-25 | Substituted phenylhexanones of use as intermediates in steroid synthesis |
GB24847/64A GB975592A (en) | 1959-09-25 | 1959-09-25 | Diketones |
DE19601793617 DE1793617A1 (en) | 1959-09-25 | 1960-09-20 | Substituted octalinones and tetrahydroindanones |
DE19601443083 DE1443083A1 (en) | 1959-09-25 | 1960-09-20 | 13-alkyl-1,3,5 (10), 8 (9) - (or 9,11) -gonatetraene and process for their preparation |
DE19601618942 DE1618942B2 (en) | 1959-09-25 | 1960-09-20 | NEW DIKETONE AND A METHOD FOR THEIR PRODUCTION |
DE19601443082D DE1443082B1 (en) | 1959-09-25 | 1960-09-20 | Tetracyclic diene ketones |
DE19601793651 DE1793651C3 (en) | 1959-09-25 | 1960-09-20 | Dicyclic triketones and a process for their preparation |
DK376260AA DK127592B (en) | 1959-09-25 | 1960-09-23 | Substituted phenylhexanones for use as intermediates in the preparation of gonan derivatives. |
SE16896/68A SE358146B (en) | 1959-09-25 | 1960-09-23 | |
SE9089/60A SE305866B (en) | 1959-09-25 | 1960-09-23 | |
SE9087/60A SE309981B (en) | 1959-09-25 | 1960-09-23 | |
CH1078660A CH421947A (en) | 1959-09-25 | 1960-09-23 | Process for the production of ketones |
CH1078560A CH421929A (en) | 1959-09-25 | 1960-09-23 | Process for the preparation of an arylalkanone |
IT16634/60A IT1061736B (en) | 1959-09-25 | 1960-09-24 | PROCESSES FOR THE PREPARATION OF REPLACED ARIL-ALCHYL KETONES |
GB40557/60A GB975594A (en) | 1959-09-25 | 1960-11-25 | Substituted octalinones and tetrahydro-indanones of use as intermediates in steroid synthesis |
DK273271AA DK128534B (en) | 1959-09-25 | 1971-06-04 | 13-Alkyl-Δ <1,3,5 (10), 8,14> -17-oxogonapentaenes for use as intermediates in the synthesis of corresponding steroids containing a saturated D-ring or saturated C- and D-rings. |
DK273371A DK130343B (en) | 1959-09-25 | 1971-06-04 | 2-Alkylcyclopentane-1,3-diones for use as intermediates in the preparation of 18-homologated steroids. |
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB32620/59A GB975593A (en) | 1959-09-25 | 1959-09-25 | Substituted phenylhexanones of use as intermediates in steroid synthesis |
GB589760 | 1960-02-19 | ||
GB4055960 | 1960-11-25 | ||
GB4055860 | 1960-11-25 | ||
GB40557/60A GB975594A (en) | 1959-09-25 | 1960-11-25 | Substituted octalinones and tetrahydro-indanones of use as intermediates in steroid synthesis |
Publications (1)
Publication Number | Publication Date |
---|---|
GB975594A true GB975594A (en) | 1964-11-18 |
Family
ID=27515788
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB40557/60A Expired GB975594A (en) | 1959-09-25 | 1960-11-25 | Substituted octalinones and tetrahydro-indanones of use as intermediates in steroid synthesis |
Country Status (4)
Country | Link |
---|---|
CH (1) | CH421929A (en) |
GB (1) | GB975594A (en) |
IT (1) | IT1061736B (en) |
SE (1) | SE309981B (en) |
-
1960
- 1960-09-23 SE SE9087/60A patent/SE309981B/xx unknown
- 1960-09-23 CH CH1078560A patent/CH421929A/en unknown
- 1960-09-24 IT IT16634/60A patent/IT1061736B/en active
- 1960-11-25 GB GB40557/60A patent/GB975594A/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
SE309981B (en) | 1969-04-14 |
IT1061736B (en) | 1983-04-30 |
CH421929A (en) | 1966-10-15 |
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