GB975595A - Substituted decalones and hexahydro-indanones of use as intermediates in steroid synthesis - Google Patents

Substituted decalones and hexahydro-indanones of use as intermediates in steroid synthesis

Info

Publication number
GB975595A
GB975595A GB3262159A GB3262159A GB975595A GB 975595 A GB975595 A GB 975595A GB 3262159 A GB3262159 A GB 3262159A GB 3262159 A GB3262159 A GB 3262159A GB 975595 A GB975595 A GB 975595A
Authority
GB
United Kingdom
Prior art keywords
carbonyl
hydroxymethylene
ethylene
phenyl
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3262159A
Inventor
Gordon Alan Hughes
Herchel Smith
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to GB3262159A priority Critical patent/GB975595A/en
Priority to DE1960S0070441 priority patent/DE1443084B2/en
Priority to DE19601793617 priority patent/DE1793617A1/en
Priority to DE19601443082D priority patent/DE1443082B1/en
Priority to DE19601443083 priority patent/DE1443083A1/en
Priority to CH1078660A priority patent/CH421947A/en
Priority to CH1078860A priority patent/CH409953A/en
Priority to SE908860A priority patent/SE306317B/xx
Priority to CH1078760A priority patent/CH409937A/en
Priority to SE9089/60A priority patent/SE305866B/xx
Priority to BE595387A priority patent/BE595387A/en
Priority to NL256210A priority patent/NL111255C/xx
Publication of GB975595A publication Critical patent/GB975595A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/657—Unsaturated compounds containing a keto groups being part of a ring containing six-membered aromatic rings
    • C07C49/665—Unsaturated compounds containing a keto groups being part of a ring containing six-membered aromatic rings a keto group being part of a condensed ring system
    • C07C49/67—Unsaturated compounds containing a keto groups being part of a ring containing six-membered aromatic rings a keto group being part of a condensed ring system having two rings, e.g. tetralones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)

Abstract

The invention comprises compounds of formula <FORM:0975595/C1/1> wherein Ar is phenyl which may carry as sole substituent in the m-position a hydroxy, alkoxy, acyloxy, amino, acylamino or alkylamino group, each R is H or alkyl, R1 is alkyl, Q is methylene or ethylene, Y is carbonyl, ketalised carbonyl, hydroxymethylene or acyloxymethylene and the junction of the rings in trans. Such compounds -and those in which more generally Ar is phenyl having an ortho-position free of substituents and Y is carbonyl or hydroxymethylene or a derivative group convertible by hydrolysis into carbonyl or hydroxymethylene-are prepared by reducing the corresponding dehydro compound <FORM:0975595/C1/2> at the ethylene linkage with introduction of the hydrogen atom shows as H trans. to R1, as e.g. by catalytic hydrogenation. The examples describe the preparation of those compounds of the first formula wherein (a) R1 is methyl, R is H, Ar is m-methoxyphenyl, Y is carbonyl or hydroxymethylene and Q is methylene or ethylene by reduction and in the case of diketones by oxidation of the ketols; (b) R1 is methyl, R is H, Ar is phenyl, Y is carbonyl or ethylenedioxymethylene and Q is ethylene by reduction. Specifications 975,591, 975,592, 975,593, 975,594 and 975,596 are referred to.
GB3262159A 1959-09-25 1959-09-25 Substituted decalones and hexahydro-indanones of use as intermediates in steroid synthesis Expired GB975595A (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
GB3262159A GB975595A (en) 1959-09-25 1959-09-25 Substituted decalones and hexahydro-indanones of use as intermediates in steroid synthesis
DE1960S0070441 DE1443084B2 (en) 1959-09-25 1960-09-20 HYDRATED INDAN-5-ON DERIVATIVES AND METHOD FOR THEIR PRODUCTION
DE19601793617 DE1793617A1 (en) 1959-09-25 1960-09-20 Substituted octalinones and tetrahydroindanones
DE19601443082D DE1443082B1 (en) 1959-09-25 1960-09-20 Tetracyclic diene ketones
DE19601443083 DE1443083A1 (en) 1959-09-25 1960-09-20 13-alkyl-1,3,5 (10), 8 (9) - (or 9,11) -gonatetraene and process for their preparation
CH1078660A CH421947A (en) 1959-09-25 1960-09-23 Process for the production of ketones
CH1078860A CH409953A (en) 1959-09-25 1960-09-23 Process for the preparation of tetracyclic compounds
SE908860A SE306317B (en) 1959-09-25 1960-09-23
CH1078760A CH409937A (en) 1959-09-25 1960-09-23 Process for the preparation of polycyclic compounds
SE9089/60A SE305866B (en) 1959-09-25 1960-09-23
BE595387A BE595387A (en) 1959-09-25 1960-09-23 Ketone compounds.
NL256210A NL111255C (en) 1959-09-25 1960-09-23

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB3262159A GB975595A (en) 1959-09-25 1959-09-25 Substituted decalones and hexahydro-indanones of use as intermediates in steroid synthesis
GB589960 1960-02-19

Publications (1)

Publication Number Publication Date
GB975595A true GB975595A (en) 1964-11-18

Family

ID=26240244

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3262159A Expired GB975595A (en) 1959-09-25 1959-09-25 Substituted decalones and hexahydro-indanones of use as intermediates in steroid synthesis

Country Status (4)

Country Link
CH (2) CH409953A (en)
DE (1) DE1443084B2 (en)
GB (1) GB975595A (en)
SE (1) SE306317B (en)

Also Published As

Publication number Publication date
CH409937A (en) 1966-03-31
SE306317B (en) 1968-11-25
DE1443084A1 (en) 1968-10-24
DE1443084B2 (en) 1977-03-10
CH409953A (en) 1966-03-31

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