GB974918A - 10-substituted derivatives of yohimbane alkaloids - Google Patents
10-substituted derivatives of yohimbane alkaloidsInfo
- Publication number
- GB974918A GB974918A GB42822/62A GB4282262A GB974918A GB 974918 A GB974918 A GB 974918A GB 42822/62 A GB42822/62 A GB 42822/62A GB 4282262 A GB4282262 A GB 4282262A GB 974918 A GB974918 A GB 974918A
- Authority
- GB
- United Kingdom
- Prior art keywords
- succinic
- yohimbane
- quaternary ammonium
- ammonium salts
- acid addition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
The invention comprises yohimbane derivatives of the formula <FORM:0974918/C1/1> wherein R is hydrogen or C1-4 alkyl and their pharmaceutically acceptable acid addition and quaternary ammonium salts together with the process for their preparation by heating an aqueous acid solution of the corresponding 10-diazonium chloride and, if the 10-alkoxy compound is desired, reacting the resulting 10-hydroxy compound with a diazo-alkane. The free base may be converted into its acid addition or quaternary ammonium salts by reaction with an organic or inorganic acid such as maleic, fumaric, benzoic, succinic, methylsulphonic, sulphonic, citric, tartaric, salicylic, malic, cinnamic, hydrochloric, hydrobromic or succinic or with an alkyl halide or other reactive ester such as a sulphate or sulphonate. Pharmaceutical preparations having activity as an algesics and tranquilizers comprise the above compounds and a carrier, suitably in the form of tablets, capsules, elixirs, solutions, suspensions or suppositories.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB42822/62A GB974918A (en) | 1962-11-13 | 1962-11-13 | 10-substituted derivatives of yohimbane alkaloids |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB42822/62A GB974918A (en) | 1962-11-13 | 1962-11-13 | 10-substituted derivatives of yohimbane alkaloids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB974918A true GB974918A (en) | 1964-11-11 |
Family
ID=10426128
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB42822/62A Expired GB974918A (en) | 1962-11-13 | 1962-11-13 | 10-substituted derivatives of yohimbane alkaloids |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB974918A (en) |
-
1962
- 1962-11-13 GB GB42822/62A patent/GB974918A/en not_active Expired
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