GB969292A - Novel octahydro-phenanthrene derivatives and a process for the manufacture thereof - Google Patents

Novel octahydro-phenanthrene derivatives and a process for the manufacture thereof

Info

Publication number
GB969292A
GB969292A GB47638/62A GB4763862A GB969292A GB 969292 A GB969292 A GB 969292A GB 47638/62 A GB47638/62 A GB 47638/62A GB 4763862 A GB4763862 A GB 4763862A GB 969292 A GB969292 A GB 969292A
Authority
GB
United Kingdom
Prior art keywords
carbon atoms
acid halides
groups
formula
halides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB47638/62A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of GB969292A publication Critical patent/GB969292A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C07C51/487—Separation; Purification; Stabilisation; Use of additives by treatment giving rise to chemical modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/16—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation
    • C07C51/29—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation with halogen-containing compounds which may be formed in situ
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/36—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by hydrogenation of carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/58—Preparation of carboxylic acid halides
    • C07C51/60—Preparation of carboxylic acid halides by conversion of carboxylic acids or their anhydrides or esters, lactones, salts into halides with the same carboxylic acid part
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/22—Ortho- or ortho- and peri-condensed systems containing three rings containing only six-membered rings
    • C07C2603/26—Phenanthrenes; Hydrogenated phenanthrenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The invention comprises compounds of the formula: <FORM:0969292/C1/1> (wherein A is the group NR1R2, R1 and R1 being hydrogen atoms, alkyl groups of at most 6 carbon atoms, dialkylaminoethyl groups wherein each alkyl group contains at most 6 carbon atoms, or hydroxy-ethyl groups, or R1 and R2 together are an alkylene chain of 4 to 7 carbon atoms) and their preparation by reacting the appropriate acid halides with the amines HNR1R2. Examples are given, a hydrochloride of one product being described. Acid halides of the formula: <FORM:0969292/C1/2> (wherein X is a halogen atom) are prepared from the corresponding free acids or alkali metal salts thereof and oxalyl halides or inorganic acid halides. The octahydrophenanthrene derivatives of the invention, which are stated to be useful as hypocholesterolenic, antigonadotropin and estrogenic agents, may be made up into pharmaceutical compositions with suitable carriers. These may take the form of tablets, dragees, suppositories, capsules, solutions, emulsions or suspensions, and may contain preserving, stabilizing, wetting or emulsifying agents, salts for varying the osmotic pressure or buffers. Compositions containing 2b -(N,N-dimethylcarbamyl)-7-methoxy-1, 2, 3, 4, 4ab , 9, 10, 10ab -octa hydrophenanthrene are described. Specification 948,583 is referred to.
GB47638/62A 1961-12-18 1962-12-18 Novel octahydro-phenanthrene derivatives and a process for the manufacture thereof Expired GB969292A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US16028961A 1961-12-18 1961-12-18

Publications (1)

Publication Number Publication Date
GB969292A true GB969292A (en) 1964-09-09

Family

ID=22576279

Family Applications (1)

Application Number Title Priority Date Filing Date
GB47638/62A Expired GB969292A (en) 1961-12-18 1962-12-18 Novel octahydro-phenanthrene derivatives and a process for the manufacture thereof

Country Status (3)

Country Link
ES (1) ES283465A1 (en)
FR (1) FR2244M (en)
GB (1) GB969292A (en)

Also Published As

Publication number Publication date
FR2244M (en) 1963-12-30
ES283465A1 (en) 1963-07-01

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