GB922269A - Improvements in or relating to derivatives of 1, 2, 3, 6-tetrahydro-2, 6-dioxo-4-pyrimidine-carboxylic acid - Google Patents

Improvements in or relating to derivatives of 1, 2, 3, 6-tetrahydro-2, 6-dioxo-4-pyrimidine-carboxylic acid

Info

Publication number
GB922269A
GB922269A GB43119/59A GB4311959A GB922269A GB 922269 A GB922269 A GB 922269A GB 43119/59 A GB43119/59 A GB 43119/59A GB 4311959 A GB4311959 A GB 4311959A GB 922269 A GB922269 A GB 922269A
Authority
GB
United Kingdom
Prior art keywords
uracil
carboxylic acid
halide
derivatives
reacting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB43119/59A
Inventor
Cornelis Ugo Kloosterman
Jan Kok
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Konink Ind Mij Vorheen Noury &
Original Assignee
Konink Ind Mij Vorheen Noury &
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Konink Ind Mij Vorheen Noury & filed Critical Konink Ind Mij Vorheen Noury &
Priority to GB43119/59A priority Critical patent/GB922269A/en
Priority to BE598243A priority patent/BE598243A/en
Priority to CH1412060A priority patent/CH389624A/en
Priority to CH145965A priority patent/CH412914A/en
Publication of GB922269A publication Critical patent/GB922269A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

The invention comprises compounds of the formula <FORM:0922269/IV(a)/1> in which X is one of the groups <FORM:0922269/IV(a)/2> (wherein R is hydrogen or a hydrocarbon group of at most 4 carbon atoms and R1, R2, R3 and R4 are hydrocarbon groups each containing at most 4 carbon atoms, and n is 1, 2, 3 or 4) and salts thereof; and their preparation by reacting a 6-uracil carbonyl halide with the appropriate compound HX. The halide starting material is advantageously prepared by reacting an alkali metal salt of 6-uracil carboxylic acid with oxalyl chloride, the reaction product being used as such without isolation of the pure halide. Examples are given, the products being isolated as their hydrochlorides. The uracil derivatives of the invention, which are stated to be useful in controlling the growth of micro-organisms and as cytostatics, may be formulated as pharmaceutical compositions such as tablets, pills, capsules, ampoules or other shaped products.
GB43119/59A 1959-12-18 1959-12-18 Improvements in or relating to derivatives of 1, 2, 3, 6-tetrahydro-2, 6-dioxo-4-pyrimidine-carboxylic acid Expired GB922269A (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
GB43119/59A GB922269A (en) 1959-12-18 1959-12-18 Improvements in or relating to derivatives of 1, 2, 3, 6-tetrahydro-2, 6-dioxo-4-pyrimidine-carboxylic acid
BE598243A BE598243A (en) 1959-12-18 1960-12-16 Process for the preparation of new therapeutically active derivatives of 1,2,3,6-tetrahydro-2,6-dioxo-4-pyrimidine carboxylic acid
CH1412060A CH389624A (en) 1959-12-18 1960-12-17 Process for the preparation of derivatives of 1,2,3,6-tetrahydro-2,6-dioxo-4-pyrimidine-carboxylic acid
CH145965A CH412914A (en) 1959-12-18 1960-12-17 Process for the preparation of derivatives of 1,2,3,6-tetrahydro-2,6-dioxo-4-pyrimidine-carboxylic acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB43119/59A GB922269A (en) 1959-12-18 1959-12-18 Improvements in or relating to derivatives of 1, 2, 3, 6-tetrahydro-2, 6-dioxo-4-pyrimidine-carboxylic acid

Publications (1)

Publication Number Publication Date
GB922269A true GB922269A (en) 1963-03-27

Family

ID=10427398

Family Applications (1)

Application Number Title Priority Date Filing Date
GB43119/59A Expired GB922269A (en) 1959-12-18 1959-12-18 Improvements in or relating to derivatives of 1, 2, 3, 6-tetrahydro-2, 6-dioxo-4-pyrimidine-carboxylic acid

Country Status (3)

Country Link
BE (1) BE598243A (en)
CH (2) CH389624A (en)
GB (1) GB922269A (en)

Also Published As

Publication number Publication date
CH389624A (en) 1965-03-31
BE598243A (en) 1961-06-16
CH412914A (en) 1966-05-15

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