GB963717A - Hydrohalogenation of 9,11-epoxy steroids - Google Patents

Hydrohalogenation of 9,11-epoxy steroids

Info

Publication number
GB963717A
GB963717A GB251363A GB251363A GB963717A GB 963717 A GB963717 A GB 963717A GB 251363 A GB251363 A GB 251363A GB 251363 A GB251363 A GB 251363A GB 963717 A GB963717 A GB 963717A
Authority
GB
United Kingdom
Prior art keywords
steroid
methyl
epoxy
hydrohalogenation
pregnadiene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB251363A
Inventor
Herbert Abraham Gerber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Scherico Ltd
Original Assignee
Scherico Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to BE634881D priority Critical patent/BE634881A/xx
Application filed by Scherico Ltd filed Critical Scherico Ltd
Priority to GB251363A priority patent/GB963717A/en
Publication of GB963717A publication Critical patent/GB963717A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)

Abstract

An improvement in the process for the preparation of a 9a -halo-11b -hydroxy steroid by reaction of a hydrogen halide with the corresponding 9b ,11b -epoxy steroid, comprises treating a soluble 9b ,11b -epoxy steroid with an aqueous solution of hydrogen chloride or hydrogen fluoride in respective concentrations of about 30% to about 38% and about 48% to about 79% calculated on a weight to weight basis. Preferably treatment is effected at -30 DEG C. to 35 DEG C. As soluble steroid there may be used 16a -methyl-9b ,11b -oxido-1 ,4-pregnadiene-17a , 21-diol-3,20-dione and 16a -methyl-9b , 11b -oxido-1, 4-pregnadiene-17a , 21-diol-3, 20-dione or the corresponding 16b -methyl isomers.
GB251363A 1963-01-21 1963-01-21 Hydrohalogenation of 9,11-epoxy steroids Expired GB963717A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
BE634881D BE634881A (en) 1963-01-21
GB251363A GB963717A (en) 1963-01-21 1963-01-21 Hydrohalogenation of 9,11-epoxy steroids

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB251363A GB963717A (en) 1963-01-21 1963-01-21 Hydrohalogenation of 9,11-epoxy steroids

Publications (1)

Publication Number Publication Date
GB963717A true GB963717A (en) 1964-07-15

Family

ID=9740895

Family Applications (1)

Application Number Title Priority Date Filing Date
GB251363A Expired GB963717A (en) 1963-01-21 1963-01-21 Hydrohalogenation of 9,11-epoxy steroids

Country Status (2)

Country Link
BE (1) BE634881A (en)
GB (1) GB963717A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0170500A2 (en) * 1984-07-25 1986-02-05 Hovione Inter Ltd. Novel 9 alpha-fluoro- or chloro-corticosteroid esters and a process for their preparation

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0170500A2 (en) * 1984-07-25 1986-02-05 Hovione Inter Ltd. Novel 9 alpha-fluoro- or chloro-corticosteroid esters and a process for their preparation
EP0170500A3 (en) * 1984-07-25 1986-06-11 Hovione Inter Ltd. Novel 9 alpha-fluoro- or chloro-corticosteroid esters and a process for their preparation

Also Published As

Publication number Publication date
BE634881A (en)

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