GB961510A - Benzhydrol derivative - Google Patents
Benzhydrol derivativeInfo
- Publication number
- GB961510A GB961510A GB45554/62A GB4555462A GB961510A GB 961510 A GB961510 A GB 961510A GB 45554/62 A GB45554/62 A GB 45554/62A GB 4555462 A GB4555462 A GB 4555462A GB 961510 A GB961510 A GB 961510A
- Authority
- GB
- United Kingdom
- Prior art keywords
- ether
- methylbenzhydryl
- acid
- methylaminoethyl
- reacting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- QILSFLSDHQAZET-UHFFFAOYSA-N diphenylmethanol Chemical class C=1C=CC=CC=1C(O)C1=CC=CC=C1 QILSFLSDHQAZET-UHFFFAOYSA-N 0.000 title 1
- BAVYZALUXZFZLV-UHFFFAOYSA-N Methylamine Chemical compound NC BAVYZALUXZFZLV-UHFFFAOYSA-N 0.000 abstract 5
- -1 2-methylbenzhydryl halide Chemical class 0.000 abstract 3
- MXHXXJOHFRHBFB-UHFFFAOYSA-N (2-methylphenyl)-phenylmethanol Chemical compound CC1=CC=CC=C1C(O)C1=CC=CC=C1 MXHXXJOHFRHBFB-UHFFFAOYSA-N 0.000 abstract 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 238000002360 preparation method Methods 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 abstract 2
- IAVAWLHIBKWFBH-UHFFFAOYSA-N 2-[[2-(2-methylphenyl)phenyl]methoxy]acetic acid Chemical compound C1(=C(C=CC=C1)C1=C(C=CC=C1)COCC(=O)O)C IAVAWLHIBKWFBH-UHFFFAOYSA-N 0.000 abstract 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 abstract 1
- 208000020401 Depressive disease Diseases 0.000 abstract 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 abstract 1
- YXHKONLOYHBTNS-UHFFFAOYSA-N Diazomethane Chemical compound C=[N+]=[N-] YXHKONLOYHBTNS-UHFFFAOYSA-N 0.000 abstract 1
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 abstract 1
- 102000010909 Monoamine Oxidase Human genes 0.000 abstract 1
- 108010062431 Monoamine oxidase Proteins 0.000 abstract 1
- WCUNAJXHJOYYGT-UHFFFAOYSA-N N-benzyl-N-methyl-2-[(2-methylphenyl)-phenylmethoxy]ethanamine Chemical compound CC1=C(C(C2=CC=CC=C2)OCCN(C)CC2=CC=CC=C2)C=CC=C1 WCUNAJXHJOYYGT-UHFFFAOYSA-N 0.000 abstract 1
- RIMQKQVHCNRHRG-UHFFFAOYSA-N N-methyl-2-[[2-(2-methylphenyl)phenyl]methoxy]acetamide Chemical compound CNC(COCC1=C(C=CC=C1)C1=C(C=CC=C1)C)=O RIMQKQVHCNRHRG-UHFFFAOYSA-N 0.000 abstract 1
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 abstract 1
- PVQATPQSBYNMGE-UHFFFAOYSA-N [benzhydryloxy(phenyl)methyl]benzene Chemical compound C=1C=CC=CC=1C(C=1C=CC=CC=1)OC(C=1C=CC=CC=1)C1=CC=CC=C1 PVQATPQSBYNMGE-UHFFFAOYSA-N 0.000 abstract 1
- 239000002775 capsule Substances 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 238000009903 catalytic hydrogenation reaction Methods 0.000 abstract 1
- FOCAUTSVDIKZOP-UHFFFAOYSA-N chloroacetic acid Chemical compound OC(=O)CCl FOCAUTSVDIKZOP-UHFFFAOYSA-N 0.000 abstract 1
- 230000000911 decarboxylating effect Effects 0.000 abstract 1
- 230000001335 demethylating effect Effects 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 239000000839 emulsion Substances 0.000 abstract 1
- JMANVNJQNLATNU-UHFFFAOYSA-N glycolonitrile Natural products N#CC#N JMANVNJQNLATNU-UHFFFAOYSA-N 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 238000002347 injection Methods 0.000 abstract 1
- 239000007924 injection Substances 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 150000004702 methyl esters Chemical class 0.000 abstract 1
- ZCWJYYZVMJJSME-UHFFFAOYSA-N methyl-[2-[(2-methylphenyl)-phenylmethoxy]ethyl]carbamic acid Chemical compound CC1=C(C(C2=CC=CC=C2)OCCN(C)C(=O)O)C=CC=C1 ZCWJYYZVMJJSME-UHFFFAOYSA-N 0.000 abstract 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 1
- 239000004006 olive oil Substances 0.000 abstract 1
- 235000008390 olive oil Nutrition 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 239000006187 pill Substances 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- 239000008223 sterile water Substances 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
- 239000003826 tablet Substances 0.000 abstract 1
- 229940095064 tartrate Drugs 0.000 abstract 1
- PNYKGCPSFKLFKA-UHFFFAOYSA-N tofenacin Chemical compound C=1C=CC=C(C)C=1C(OCCNC)C1=CC=CC=C1 PNYKGCPSFKLFKA-UHFFFAOYSA-N 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
- C07C43/14—Unsaturated ethers
- C07C43/17—Unsaturated ethers containing halogen
- C07C43/174—Unsaturated ethers containing halogen containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
- C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
Priority Applications (14)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL288676D NL288676A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1962-11-30 | ||
| NL125245D NL125245C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1962-11-30 | ||
| BE628167D BE628167A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1962-11-30 | ||
| DENDAT1248672D DE1248672B (de) | 1962-11-30 | Verfahren zur Herstellung von N Methylarrunoathyl-2 methylbenzhydryl ather und dessen Saureadditionssalzen | |
| GB45554/62A GB961510A (en) | 1962-11-30 | 1962-11-30 | Benzhydrol derivative |
| FI2311/62A FI40169B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1962-11-30 | 1962-12-27 | |
| ES285194A ES285194A1 (es) | 1962-11-30 | 1963-02-16 | Procedimiento para la preparación de nuevos ésteres benzohidrílicos |
| CH2066A CH478757A (de) | 1962-11-30 | 1963-03-01 | Verfahren zur Herstellung eines neuen Benzhydryläthers |
| CH261363A CH422003A (de) | 1962-11-30 | 1963-03-01 | Verfahren zur Herstellung eines neuen Benzhydryläthers |
| CH1966A CH490327A (de) | 1962-11-30 | 1963-03-01 | Verfahren zur Herstellung eines neuen Benzhydryläthers |
| CH1866A CH479541A (de) | 1962-11-30 | 1963-03-01 | Verfahren zur Herstellung eines neuen Benzhydryläthers |
| FR948146A FR3696M (fr) | 1962-11-30 | 1963-09-20 | Médicament inhibiteur de la monoaminoxydase a base d'un nouvel éther benzhydrylique. |
| FR948153A FR1372106A (fr) | 1962-11-30 | 1963-09-20 | Nouvel éther benzhydrylique et son procédé de préparation |
| US496173A US3407258A (en) | 1962-11-30 | 1965-10-14 | Methods of treating arteriosclerotic vertigo and depression |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB45554/62A GB961510A (en) | 1962-11-30 | 1962-11-30 | Benzhydrol derivative |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB961510A true GB961510A (en) | 1964-06-24 |
Family
ID=10437641
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB45554/62A Expired GB961510A (en) | 1962-11-30 | 1962-11-30 | Benzhydrol derivative |
Country Status (9)
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT220619B (de) * | 1960-06-30 | 1962-04-10 | Sigmapharm Dr H Punzengruber & | Verfahren zur Herstellung von Aminoalkylbenzhydryläthern |
-
0
- BE BE628167D patent/BE628167A/xx unknown
- NL NL288676D patent/NL288676A/xx unknown
- NL NL125245D patent/NL125245C/xx active
- DE DENDAT1248672D patent/DE1248672B/de active Pending
-
1962
- 1962-11-30 GB GB45554/62A patent/GB961510A/en not_active Expired
- 1962-12-27 FI FI2311/62A patent/FI40169B/fi active
-
1963
- 1963-02-16 ES ES285194A patent/ES285194A1/es not_active Expired
- 1963-03-01 CH CH261363A patent/CH422003A/de unknown
- 1963-03-01 CH CH1966A patent/CH490327A/de not_active IP Right Cessation
- 1963-09-20 FR FR948146A patent/FR3696M/fr active Active
-
1965
- 1965-10-14 US US496173A patent/US3407258A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| NL125245C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | |
| US3407258A (en) | 1968-10-22 |
| BE628167A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | |
| FR3696M (fr) | 1965-11-22 |
| CH490327A (de) | 1970-05-15 |
| NL288676A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | |
| CH422003A (de) | 1966-10-15 |
| FI40169B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1968-07-31 |
| DE1248672B (de) | 1967-08-31 |
| ES285194A1 (es) | 1963-08-01 |
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