GB1311044A - 2-hydroxypropylamine derivatives their preparation and pharma ceutical preparations comprising them - Google Patents

2-hydroxypropylamine derivatives their preparation and pharma ceutical preparations comprising them

Info

Publication number
GB1311044A
GB1311044A GB79371A GB79371A GB1311044A GB 1311044 A GB1311044 A GB 1311044A GB 79371 A GB79371 A GB 79371A GB 79371 A GB79371 A GB 79371A GB 1311044 A GB1311044 A GB 1311044A
Authority
GB
United Kingdom
Prior art keywords
formula
compounds
reacting
optionally substituted
hydrocarbon radical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB79371A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH20470A external-priority patent/CH554311A/en
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of GB1311044A publication Critical patent/GB1311044A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
    • C07C275/34—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D263/06—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by oxygen atoms, attached to ring carbon atoms

Abstract

1311044 2-Hydroxypropylamine derivatives CIBA-GEIGY AG 7 Jan 1971 [8 Jan 1970 13 Nov 1970] 793/71 Heading C2C The invention comprises novel 2-hydroxypropylamine derivatives of the Formula I: where R 1 is H or an optionally substituted monovalent hydrocarbon radical of aliphatic character, R is an optionally substituted monovalent hydrocarbon radical of aliphatic character, or R 1 and R 2 together represent a divalent hydrocarbon radical of aliphatic character, which can optionally be interrupted by heteroatoms and/or substituted, Ph represents an optionally substituted meta- or para-phenylene, and R 3 is an aliphatic or cycloaliphatic radical, their condensation products with aldehydes or ketones, and acid addition salts thereof. The above novel compounds are prepared by reacting compounds of the formula wherein X 1 is OH and Z is a reactive esterified hydroxyl group, or X 1 and Z together form an epoxy group, with amines of the formula and, if desired, reacting the resulting compound with aldehydes or ketones, or by reacting compounds of the formula or of the formula with compounds of the formula Z-R 3 , or by reacting compounds of the formula with compounds of the formula Pharmaceutical compositions, suitable for enteral or parenteral administration, contain the above novel compounds or physiologically tolerable acid addition salts thereof, in admixture or conjunction with pharmaceutically unstable organic or inorganic, solid or liquid carriers. The compounds inhibit cardioselective #-receptors. Reference has been directed by the Comptroller to Specification 1,260,893.
GB79371A 1970-01-08 1971-01-07 2-hydroxypropylamine derivatives their preparation and pharma ceutical preparations comprising them Expired GB1311044A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH20470A CH554311A (en) 1970-01-08 1970-01-08 Cardioactive amines
CH1678870 1970-11-13

Publications (1)

Publication Number Publication Date
GB1311044A true GB1311044A (en) 1973-03-21

Family

ID=25683866

Family Applications (1)

Application Number Title Priority Date Filing Date
GB79371A Expired GB1311044A (en) 1970-01-08 1971-01-07 2-hydroxypropylamine derivatives their preparation and pharma ceutical preparations comprising them

Country Status (15)

Country Link
JP (3) JPS5518700B1 (en)
AR (6) AR207306A1 (en)
AT (3) AT318647B (en)
BE (1) BE761321A (en)
CA (1) CA1149819A (en)
CS (6) CS155963B2 (en)
DE (1) DE2100323C3 (en)
DK (1) DK129650B (en)
ES (6) ES387059A1 (en)
FR (1) FR2081419B1 (en)
GB (1) GB1311044A (en)
HU (1) HU168606B (en)
NL (1) NL167685C (en)
PL (1) PL92434B1 (en)
SE (1) SE361308B (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5013356A (en) * 1973-06-08 1975-02-12
JPS5013357A (en) * 1973-06-08 1975-02-12
EP2653428B1 (en) 2012-04-16 2015-09-30 Fernsteuergeräte Kurt Oelsch GmbH Wire-actuated linear encoder

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3935259A (en) 1970-01-08 1976-01-27 Ciba-Geigy Corporation New amines and processes for their manufacture
US4038313A (en) * 1970-01-08 1977-07-26 Ciba-Geigy Corporation Cycloalkylureido phenoxy propanolamines
JPS5614661B2 (en) * 1971-12-23 1981-04-06
AT321315B (en) * 1972-02-28 1975-03-25 Chemie Linz Ag Process for the preparation of new ureidophenoxypropylamine derivatives and their salts
JPS53105456A (en) * 1978-02-25 1978-09-13 Dresden Arzneimittel Method for production of derivative of ureidphenoxyyalkanolamine
JPS53105452A (en) * 1978-02-25 1978-09-13 Dresden Arzneimittel Method for production of derivative of ureidphenoxyyalkanolamine
JPS53105454A (en) * 1978-02-25 1978-09-13 Dresden Arzneimittel Method for production of derivative of ureidphenoxyyalkanolamine
US4177280A (en) * 1978-07-03 1979-12-04 Syntex (U.S.A.) Inc. Bicyclo[3.1.0]hexyl-substituted carbonylaminophenoxy cardiovascular agents
JPS61178357U (en) * 1985-04-24 1986-11-07
JPS63147473U (en) * 1987-03-16 1988-09-28
JPS649170U (en) * 1988-07-15 1989-01-18

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5013356A (en) * 1973-06-08 1975-02-12
JPS5013357A (en) * 1973-06-08 1975-02-12
EP2653428B1 (en) 2012-04-16 2015-09-30 Fernsteuergeräte Kurt Oelsch GmbH Wire-actuated linear encoder

Also Published As

Publication number Publication date
JPS563862B1 (en) 1981-01-27
CS155960B2 (en) 1974-06-24
CS155961B2 (en) 1974-06-24
AR207307A1 (en) 1976-09-30
SE361308B (en) 1973-10-29
FR2081419A1 (en) 1971-12-03
CA1149819A (en) 1983-07-12
AR204898A1 (en) 1976-03-19
NL7100178A (en) 1971-07-12
CS155958B2 (en) 1974-06-24
ES420201A1 (en) 1976-03-16
AR207306A1 (en) 1976-09-30
AT318650B (en) 1974-11-11
CS155959B2 (en) 1974-06-24
PL92434B1 (en) 1977-04-30
JPS5518700B1 (en) 1980-05-21
DE2100323C3 (en) 1979-02-22
ES387059A1 (en) 1974-07-01
DK129650C (en) 1975-04-01
ES420205A1 (en) 1976-03-01
BE761321A (en) 1971-07-07
AT318647B (en) 1974-11-11
NL167685B (en) 1981-08-17
FR2081419B1 (en) 1974-08-30
JPS5632305B1 (en) 1981-07-27
CS155962B2 (en) 1974-06-24
ES420202A1 (en) 1976-03-16
DK129650B (en) 1974-11-04
HU168606B (en) 1976-06-28
DE2100323A1 (en) 1972-06-15
NL167685C (en) 1982-01-18
AT318649B (en) 1974-11-11
AR194708A1 (en) 1973-08-14
AR204685A1 (en) 1976-02-27
AR203984A1 (en) 1975-11-12
ES420203A1 (en) 1976-03-01
CS155963B2 (en) 1974-06-24
ES420204A1 (en) 1976-03-01
DE2100323B2 (en) 1978-06-29

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Legal Events

Date Code Title Description
414F Notice of opposition given (sect. 14/1949)
414A Case decided by the comptroller ** specification amended (sect. 14/1949)
SPA Amended specification published
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee