ES387059A1 - 2-hydroxypropylamine derivatives their preparation and pharma ceutical preparations comprising them - Google Patents
2-hydroxypropylamine derivatives their preparation and pharma ceutical preparations comprising themInfo
- Publication number
- ES387059A1 ES387059A1 ES387059A ES387059A ES387059A1 ES 387059 A1 ES387059 A1 ES 387059A1 ES 387059 A ES387059 A ES 387059A ES 387059 A ES387059 A ES 387059A ES 387059 A1 ES387059 A1 ES 387059A1
- Authority
- ES
- Spain
- Prior art keywords
- carbon atoms
- moiety
- salts
- signifies
- hydrocarbon residue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
- C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
- C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
- C07C275/34—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D263/06—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by oxygen atoms, attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Procedure for obtaining new 1- (ureidophenoxy) -2-hydroxy -3-amino-propanes, of formula **(See formula)** wherein R1 signifies hydrogen or a monovalent hydrocarbon residue, containing 1 to 7 aliphatic carbon atoms, of which one is attached to the nitrogen atom, and R2 signifies a monovalent hydrocarbon residue, containing 1 to 7 carbon atoms aliphatic, of which one is attached to the nitrogen atom, or R1 and R2 together represent a bivalent aliphatic hydrocarbon residue with 4 to 6 carbon atoms or a bivalent aliphatic hydrocarbon residue, interrupted by an oxygen, sulfur or nitrogen atom, with 4 or 5 carbon atoms, R3 means an aliphatic or cycloaliphatic moiety containing 1 to 7 carbon atoms with 3 to 7 ring members and R4 means hydrogen, lower alkyl with 1 to 4 carbon atoms, lower alkenyl with 2 to 4 carbon atoms, lower alkynyl with 3 carbon atoms, cycloalkyl with 3 to 7 ring members, lower phenylalkyl with 1 to 4 chain carbon atoms, lower alkoxy with 1 to 4 atom os of carbon, phenyl, lower alkenyloxy with 2 to 4 carbon atoms, lower alkynyloxy with 3 carbon atoms, halogen, phenoxy, trifluomethyl or cyano, the ureido moiety being in the meta or para position relative to the moiety bearing R3, and its salts, characterized in that a compound of the general formula is reacted **(See formula)** with a compound of general formula Z2 - R3 or the salts thereof, in the presence of a basic condensing agent, where R1, R2, R3 and R4 have the meanings indicated for formula I, one of the residues Z1 and Z2 means an esterified hydroxyl group, capable of reaction and the another signifies the amino group, and X1 signifies a hydroxyl group or, when Z2 is an amino group, Z1 together with X1 forms an epoxy group, the ureido moiety being, in each case, in the meta or para position relative to the moiety that bears R3 and, if desired, the obtained isomer mixtures are separated into the pure isomers and/or the racemates obtained are separated into the optical antipodes and/or the free bases obtained are transformed into their salts or the salts obtained from the bases free. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH20470A CH554311A (en) | 1970-01-08 | 1970-01-08 | Cardioactive amines |
| CH1678870 | 1970-11-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES387059A1 true ES387059A1 (en) | 1974-07-01 |
Family
ID=25683866
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES387059A Expired ES387059A1 (en) | 1970-01-08 | 1971-01-07 | 2-hydroxypropylamine derivatives their preparation and pharma ceutical preparations comprising them |
| ES420202A Expired ES420202A1 (en) | 1970-01-08 | 1973-11-02 | 2-hydroxypropylamine derivatives their preparation and pharma ceutical preparations comprising them |
| ES420201A Expired ES420201A1 (en) | 1970-01-08 | 1973-11-02 | 2-hydroxypropylamine derivatives their preparation and pharma ceutical preparations comprising them |
| ES420205A Expired ES420205A1 (en) | 1970-01-08 | 1973-11-02 | 2-hydroxypropylamine derivatives their preparation and pharma ceutical preparations comprising them |
| ES420204A Expired ES420204A1 (en) | 1970-01-08 | 1973-11-02 | 2-hydroxypropylamine derivatives their preparation and pharma ceutical preparations comprising them |
| ES420203A Expired ES420203A1 (en) | 1970-01-08 | 1973-11-02 | 2-hydroxypropylamine derivatives their preparation and pharma ceutical preparations comprising them |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES420202A Expired ES420202A1 (en) | 1970-01-08 | 1973-11-02 | 2-hydroxypropylamine derivatives their preparation and pharma ceutical preparations comprising them |
| ES420201A Expired ES420201A1 (en) | 1970-01-08 | 1973-11-02 | 2-hydroxypropylamine derivatives their preparation and pharma ceutical preparations comprising them |
| ES420205A Expired ES420205A1 (en) | 1970-01-08 | 1973-11-02 | 2-hydroxypropylamine derivatives their preparation and pharma ceutical preparations comprising them |
| ES420204A Expired ES420204A1 (en) | 1970-01-08 | 1973-11-02 | 2-hydroxypropylamine derivatives their preparation and pharma ceutical preparations comprising them |
| ES420203A Expired ES420203A1 (en) | 1970-01-08 | 1973-11-02 | 2-hydroxypropylamine derivatives their preparation and pharma ceutical preparations comprising them |
Country Status (15)
| Country | Link |
|---|---|
| JP (3) | JPS5518700B1 (en) |
| AR (6) | AR207307A1 (en) |
| AT (3) | AT318650B (en) |
| BE (1) | BE761321A (en) |
| CA (1) | CA1149819A (en) |
| CS (6) | CS155959B2 (en) |
| DE (1) | DE2100323C3 (en) |
| DK (1) | DK129650B (en) |
| ES (6) | ES387059A1 (en) |
| FR (1) | FR2081419B1 (en) |
| GB (1) | GB1311044A (en) |
| HU (1) | HU168606B (en) |
| NL (1) | NL167685C (en) |
| PL (1) | PL92434B1 (en) |
| SE (1) | SE361308B (en) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4038313A (en) * | 1970-01-08 | 1977-07-26 | Ciba-Geigy Corporation | Cycloalkylureido phenoxy propanolamines |
| US3935259A (en) | 1970-01-08 | 1976-01-27 | Ciba-Geigy Corporation | New amines and processes for their manufacture |
| JPS5614661B2 (en) * | 1971-12-23 | 1981-04-06 | ||
| AT321315B (en) * | 1972-02-28 | 1975-03-25 | Chemie Linz Ag | Process for the preparation of new ureidophenoxypropylamine derivatives and their salts |
| JPS5013357A (en) * | 1973-06-08 | 1975-02-12 | ||
| JPS5013356A (en) * | 1973-06-08 | 1975-02-12 | ||
| JPS53105452A (en) * | 1978-02-25 | 1978-09-13 | Dresden Arzneimittel | Method for production of derivative of ureidphenoxyyalkanolamine |
| JPS53105456A (en) * | 1978-02-25 | 1978-09-13 | Dresden Arzneimittel | Method for production of derivative of ureidphenoxyyalkanolamine |
| JPS53105454A (en) * | 1978-02-25 | 1978-09-13 | Dresden Arzneimittel | Method for production of derivative of ureidphenoxyyalkanolamine |
| US4177280A (en) * | 1978-07-03 | 1979-12-04 | Syntex (U.S.A.) Inc. | Bicyclo[3.1.0]hexyl-substituted carbonylaminophenoxy cardiovascular agents |
| JPS61178357U (en) * | 1985-04-24 | 1986-11-07 | ||
| JPS63147473U (en) * | 1987-03-16 | 1988-09-28 | ||
| JPS649170U (en) * | 1988-07-15 | 1989-01-18 | ||
| DE202012101380U1 (en) | 2012-04-16 | 2012-06-15 | Fernsteuergeräte Kurt Oelsch GmbH | Cable length sensor |
-
1970
- 1970-12-23 CA CA000101368A patent/CA1149819A/en not_active Expired
- 1970-12-30 JP JP12313970A patent/JPS5518700B1/ja active Pending
-
1971
- 1971-01-01 AR AR238167A patent/AR207307A1/en active
- 1971-01-01 AR AR238164A patent/AR204685A1/en active
- 1971-01-01 AR AR238166A patent/AR204898A1/en active
- 1971-01-01 AR AR238168A patent/AR203984A1/en active
- 1971-01-01 AR AR238165A patent/AR207306A1/en active
- 1971-01-05 FR FR7100076A patent/FR2081419B1/fr not_active Expired
- 1971-01-05 DE DE2100323A patent/DE2100323C3/en not_active Expired
- 1971-01-07 GB GB79371A patent/GB1311044A/en not_active Expired
- 1971-01-07 PL PL1971178941A patent/PL92434B1/en unknown
- 1971-01-07 DK DK4771AA patent/DK129650B/en unknown
- 1971-01-07 CS CS161572A patent/CS155959B2/cs unknown
- 1971-01-07 CS CS9871*#A patent/CS155958B2/cs unknown
- 1971-01-07 AT AT922972A patent/AT318650B/en not_active IP Right Cessation
- 1971-01-07 AR AR233351A patent/AR194708A1/en active
- 1971-01-07 AT AT922872A patent/AT318649B/en not_active IP Right Cessation
- 1971-01-07 CS CS161872A patent/CS155962B2/cs unknown
- 1971-01-07 AT AT8271A patent/AT318647B/en not_active IP Right Cessation
- 1971-01-07 SE SE00101/71A patent/SE361308B/xx unknown
- 1971-01-07 NL NL7100178A patent/NL167685C/en not_active IP Right Cessation
- 1971-01-07 ES ES387059A patent/ES387059A1/en not_active Expired
- 1971-01-07 CS CS161972A patent/CS155963B2/cs unknown
- 1971-01-07 CS CS161672A patent/CS155960B2/cs unknown
- 1971-01-07 HU HUCI1073A patent/HU168606B/hu unknown
- 1971-01-07 BE BE761321A patent/BE761321A/en not_active IP Right Cessation
- 1971-01-07 CS CS161772A patent/CS155961B2/cs unknown
-
1973
- 1973-11-02 ES ES420202A patent/ES420202A1/en not_active Expired
- 1973-11-02 ES ES420201A patent/ES420201A1/en not_active Expired
- 1973-11-02 ES ES420205A patent/ES420205A1/en not_active Expired
- 1973-11-02 ES ES420204A patent/ES420204A1/en not_active Expired
- 1973-11-02 ES ES420203A patent/ES420203A1/en not_active Expired
-
1975
- 1975-06-07 JP JP6904975A patent/JPS563862B1/ja active Pending
-
1980
- 1980-06-05 JP JP7499780A patent/JPS5632305B1/ja active Pending
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