GB957257A - Manufacture of sulphanilamido-pyrimidine compounds - Google Patents

Manufacture of sulphanilamido-pyrimidine compounds

Info

Publication number
GB957257A
GB957257A GB41472/62A GB4147262A GB957257A GB 957257 A GB957257 A GB 957257A GB 41472/62 A GB41472/62 A GB 41472/62A GB 4147262 A GB4147262 A GB 4147262A GB 957257 A GB957257 A GB 957257A
Authority
GB
United Kingdom
Prior art keywords
sulphanilamido
reacting
carbon atoms
preparation
alkoxy groups
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB41472/62A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of GB957257A publication Critical patent/GB957257A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/60—Three or more oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/69—Benzenesulfonamido-pyrimidines

Abstract

The invention comprises sulphones of the formula: <FORM:0957257/C2/1> wherein R1 and R2 are alkoxy groups of 1-6 carbon atoms and R3 is an alkyl, aryl or aralkyl group; their preparation by reacting an appropriate 4-halopyrimidine with a thio compound R3S Met (wherein Met indicates an alkalimetal atom) and oxidizing the intermediate thioether obtained, and the preparation of 4-sulphanilamido-5, 6-dialkoxy pyrimidines wherein the alkoxy groups contain up to 6 carbon atoms, by reacting a sulphone of the above general formula with an alkali-metal derivative of sulphanilamide, preferably by dry heating the components at 100 DEG -150 DEG C. 4-Chloro-5, 6-dimethoxypyrimidine is made by the action of sodium methoxide on 4, 6-dichloro-5-methoxy-pyrimidine.
GB41472/62A 1961-11-09 1962-11-02 Manufacture of sulphanilamido-pyrimidine compounds Expired GB957257A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1299161A CH396916A (en) 1961-11-09 1961-11-09 Process for the preparation of new sulfonamides of the pyrimidine series

Publications (1)

Publication Number Publication Date
GB957257A true GB957257A (en) 1964-05-06

Family

ID=4388304

Family Applications (1)

Application Number Title Priority Date Filing Date
GB41472/62A Expired GB957257A (en) 1961-11-09 1962-11-02 Manufacture of sulphanilamido-pyrimidine compounds

Country Status (8)

Country Link
BE (1) BE624330A (en)
BR (1) BR6244435D0 (en)
CH (1) CH396916A (en)
DE (1) DE1192652B (en)
ES (1) ES282282A1 (en)
GB (1) GB957257A (en)
NL (1) NL285045A (en)
OA (1) OA00945A (en)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3127398A (en) * 1959-08-20 1964-03-31 Method for the preparation of

Also Published As

Publication number Publication date
CH396916A (en) 1965-08-15
BE624330A (en)
DE1192652B (en) 1965-05-13
NL285045A (en)
BR6244435D0 (en) 1973-07-19
OA00945A (en) 1968-03-22
ES282282A1 (en) 1963-05-01

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