GB2017082A - 5-Fluorouracil derivatives, process for their production and pharmaceuticals containing them - Google Patents
5-Fluorouracil derivatives, process for their production and pharmaceuticals containing themInfo
- Publication number
- GB2017082A GB2017082A GB7902010A GB7902010A GB2017082A GB 2017082 A GB2017082 A GB 2017082A GB 7902010 A GB7902010 A GB 7902010A GB 7902010 A GB7902010 A GB 7902010A GB 2017082 A GB2017082 A GB 2017082A
- Authority
- GB
- United Kingdom
- Prior art keywords
- atoms
- group
- halogen
- fluorouracil
- alkylsulphoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/553—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with halogen atoms or nitro radicals directly attached to ring carbon atoms, e.g. fluorouracil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
New 5-fluorouracil derivatives which give effective action against carinomatous diseases combined with an acceptably high compatability are 1- alkyloxyalkyl-5-fluorouracils substituted in the terminal alkyl radical and having the general formula <IMAGE> in which R represents hydrogen, an alkyl with 1 to 4 C atoms, an aralkyl with 7 to 8 C atoms or an aryl with 6 to 7 C atoms, alkylene represents an alkylene radical with 1 to 6 C atoms which can be interrupted by 1 to 2 O atoms, and X signifies halogen, mercapto, a thiosulphate group, an alkylthio or alkylsulphoxy group with in each case 1 to 4 C atoms or half of a disulphide group (-S-S-). Compounds wherein X is halogen, alkylthio or alkylsulphoxy are produced by reacting 1-halogen-alkyl ethers of the general formula <IMAGE> with 5-fluorouracil or a heavy metal or oxygen silylated derivative thereof. When X is mercapto or thiosulphate or half a disulphide group the compounds are produced by reacting a said halo-substituted derivative with a compound of silver or alkali metal with the appropriate sulphur containing group.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH254978A CH633280A5 (en) | 1978-03-09 | 1978-03-09 | 5-FLUORURACIL DERIVATIVES AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS. |
Publications (2)
Publication Number | Publication Date |
---|---|
GB2017082A true GB2017082A (en) | 1979-10-03 |
GB2017082B GB2017082B (en) | 1982-07-21 |
Family
ID=4236289
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB7902010A Expired GB2017082B (en) | 1978-03-09 | 1979-01-19 | 5-fluorouracil derivatives process for their production and pharmaceuticals containing them |
Country Status (5)
Country | Link |
---|---|
JP (1) | JPS54130586A (en) |
CH (1) | CH633280A5 (en) |
DE (1) | DE2854008A1 (en) |
FR (1) | FR2419288A1 (en) |
GB (1) | GB2017082B (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2469406A1 (en) * | 1979-11-08 | 1981-05-22 | Shionogi & Co | ORAL ADMINISTRATIVE 5-FLUOROURACIL DERIVATIVES EFFECTIVE AGAINST MALIGNANT TUMORS |
EP0046307A1 (en) * | 1980-08-19 | 1982-02-24 | Chugai Seiyaku Kabushiki Kaisha | Novel uracil derivatives, process for preparing the same and a pharmaceutical composition containing the same |
EP0064033A1 (en) * | 1981-04-28 | 1982-11-03 | Shionogi & Co., Ltd. | 5-Fluorouracil derivatives |
EP1939186A1 (en) * | 2006-12-22 | 2008-07-02 | Sulfidris S.r.l. | 5-Fluorouracil derivatives and their use for the treatment of cancer |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2005513156A (en) * | 2001-12-31 | 2005-05-12 | ファエンドォラー,ハンス,ロドルフ | Long-chain fatty alcohol substituents in antineoplastic drugs |
JP2011231015A (en) * | 2008-08-29 | 2011-11-17 | Taiho Yakuhin Kogyo Kk | Novel uracil compound having nitrogenated heterocyclic ring or salt thereof |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5331874B2 (en) * | 1973-08-11 | 1978-09-05 | ||
JPS5119778A (en) * | 1974-08-09 | 1976-02-17 | Mitsui Seiyaku Kogyo Kk | 11 chikan 55 furuororashiruruino seizoho |
-
1978
- 1978-03-09 CH CH254978A patent/CH633280A5/en not_active IP Right Cessation
- 1978-12-14 DE DE19782854008 patent/DE2854008A1/en not_active Ceased
-
1979
- 1979-01-19 GB GB7902010A patent/GB2017082B/en not_active Expired
- 1979-03-07 FR FR7905872A patent/FR2419288A1/en active Granted
- 1979-03-09 JP JP2681879A patent/JPS54130586A/en active Pending
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2469406A1 (en) * | 1979-11-08 | 1981-05-22 | Shionogi & Co | ORAL ADMINISTRATIVE 5-FLUOROURACIL DERIVATIVES EFFECTIVE AGAINST MALIGNANT TUMORS |
EP0046307A1 (en) * | 1980-08-19 | 1982-02-24 | Chugai Seiyaku Kabushiki Kaisha | Novel uracil derivatives, process for preparing the same and a pharmaceutical composition containing the same |
EP0064033A1 (en) * | 1981-04-28 | 1982-11-03 | Shionogi & Co., Ltd. | 5-Fluorouracil derivatives |
EP1939186A1 (en) * | 2006-12-22 | 2008-07-02 | Sulfidris S.r.l. | 5-Fluorouracil derivatives and their use for the treatment of cancer |
WO2008077453A1 (en) * | 2006-12-22 | 2008-07-03 | Sulfidris, S.R.L. | 5-fluorouracil derivatives and their use for the treatment of cancer |
Also Published As
Publication number | Publication date |
---|---|
FR2419288B1 (en) | 1982-11-05 |
FR2419288A1 (en) | 1979-10-05 |
CH633280A5 (en) | 1982-11-30 |
DE2854008A1 (en) | 1979-09-13 |
GB2017082B (en) | 1982-07-21 |
JPS54130586A (en) | 1979-10-09 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PCNP | Patent ceased through non-payment of renewal fee |