GB950662A - Novel basic esters and salts thereof - Google Patents
Novel basic esters and salts thereofInfo
- Publication number
- GB950662A GB950662A GB29828/61A GB2982861A GB950662A GB 950662 A GB950662 A GB 950662A GB 29828/61 A GB29828/61 A GB 29828/61A GB 2982861 A GB2982861 A GB 2982861A GB 950662 A GB950662 A GB 950662A
- Authority
- GB
- United Kingdom
- Prior art keywords
- picrate
- formula
- alkyl group
- butylethylaminoethanol
- prepared
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
The invention comprises compounds of the formula: <FORM:0950662/C2/1> (wherein R1 is a C1-4 alkyl group and R11 is a C3-6 alkyl group) and acid addition salts thereof, and their preparation by reacting an ester of the formula: <FORM:0950662/C2/2> (wherein X is a C1-4 alkyl group) with an N-substituted 2-ethylaminoethanol of the formula: <FORM:0950662/C2/3> in the presence of a catalyst, optionally followed by salt formation. The compounds of the invention have anti-tussive activity. 2-n-Propylaminoethanol is prepared by reacting ethylene chlorohydrin with an excess of propylamine, and is characterized as the picrate; it is treated with acetic anhydride to yield 2-(n-propylacetylamino) ethyl acetate and the latter is reduced with lithium aluminium hydride to 2-(n-propylethylamino) ethanol, characterized as the picrate and benzoate hydrochloride. The following substituted aminoethanols are prepared by standard methods: 2-isopropylaminoethanol, 2-isopropylethylaminoethanol, 2-n-butylethylaminoethanol, 2-s-butylaminoethanol, 2-s-butylethylaminoethanol (characterized as the picrate), 2-isobutylaminoethanol, 2-isobutylethylaminoethanol and 2-n-pentylethylaminoethanol (characterized as the acetate methiodide).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB29828/61A GB950662A (en) | 1961-08-18 | 1961-08-18 | Novel basic esters and salts thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB29828/61A GB950662A (en) | 1961-08-18 | 1961-08-18 | Novel basic esters and salts thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB950662A true GB950662A (en) | 1964-02-26 |
Family
ID=10297844
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB29828/61A Expired GB950662A (en) | 1961-08-18 | 1961-08-18 | Novel basic esters and salts thereof |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB950662A (en) |
-
1961
- 1961-08-18 GB GB29828/61A patent/GB950662A/en not_active Expired
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