GB950321A - Derivatives of iodophenyl-propionic acids and improvements in and relating to x-ray contrast media - Google Patents
Derivatives of iodophenyl-propionic acids and improvements in and relating to x-ray contrast mediaInfo
- Publication number
- GB950321A GB950321A GB2248860A GB2248860A GB950321A GB 950321 A GB950321 A GB 950321A GB 2248860 A GB2248860 A GB 2248860A GB 2248860 A GB2248860 A GB 2248860A GB 950321 A GB950321 A GB 950321A
- Authority
- GB
- United Kingdom
- Prior art keywords
- carbon atoms
- formula
- alkyl
- cycloalkyl
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
- A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
- A61K49/0495—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound intended for oral administration
Landscapes
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
The invention comprises compounds of the formula: <FORM:0950321/C2/1> in which R is hydrogen or alkyl with 1-6 carbon atoms or cycloalkyl with up to 6 carbon atoms, X is hydrogen or alkyl with 1-6 carbon atoms or a cycloalkyl with up to 6 carbon atoms and R1 and R2 either are each an alkyl radical with 2-6 carbon atoms or, together with the nitrogen atom form a non-aromatic heterocyclic ring of 5-6 members which may contain a further hetero atom, or in the case in which X is an alkyl with 1-6 carbon atoms or a cycloalkyl with up to 6 carbon atoms, may also be methyl, and also the acid addition salts of the specified compounds with physiologically acceptable inorganic and/or organic acids and salts of the specified acids (X = H in the above formula) with likewise physiologically acceptable inorganic and/or organic bases and processes for the preparation thereof wherein (a) a compound of the general formula: <FORM:0950321/C2/2> in which R and X are hydrogen or alkyl with an N-disubstituted formamide of the formula: <FORM:0950321/C2/3> in the presence of an acid reaction promoter such as an acid halide and, if desired, the product is esterified and/or converted into a salt with a non-toxic base or acid; (b) a compound of the formula: <FORM:0950321/C2/4> is reacted with a secondary amine of the formula: <FORM:0950321/C2/5> and if desired the product is esterified and/or converted into a salt; (c) an isocyanate of the general formula: <FORM:0950321/C2/6> is reacted with an N-disubstituted formamide of the formula: <FORM:0950321/C2/7> in the presence of an acid reaction promoter such as hydrogen chloride together with an inert solvent, at elevated temperature, and if desired the resulting product is esterified and/or converted into a salt; (d) a formyl compound of the general formula: <FORM:0950321/C2/8> with a secondary amine of the formula HNR1R2; R1, R2, R and X have the meanings given above and Y being a hydrocarbon radical. Heterocyclic residues specified include piperidino and morpholino. The products are employed in X-ray contrast media (see Division A5). Examples are furnished.ALSO:X-ray contrast media contain a compound of the formula <FORM:0950321/A5-A6/1> in which R is hydrogen or alkyl with 1-6 carbon atoms or cycloalkyl with to 6 carbon atoms, X is hydrogen or alkyl with 1-6 carbon atoms or a cycloalkyl with up to 6 carbon atoms and R1 and R2 either are each an alkyl group with 2-6 carbon atoms or, together with the nitrogen atom form a non-aromatic heterocyclic ring of 5-6 members which may contain a further hetero atom, or in the case in which X is an alkyl of 1-6 carbon atoms or a cycloalkyl with up to 6 carbon atoms may also be methyl, and also the acid addition salts of the specified compounds with physiologically acceptable inorganic and/or organic acids and salts of the specified acids (X=H in the above formula) with likewise physiologically acceptable inorganic and/or organic bases (see Division C2). In examples, a - ethyl - b - (3 - N - diethylamino - methylene-amino - 2,4,6 - triidophenyl) propionic acid and the corresponding 3-N-piperidino-, 3-N-morpholino, and 3-N-dimethylamino compounds are made up with conventional ingredients into tablets, dragees and capsules.
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DESC023848 | 1958-04-05 | ||
| DESCH24255A DE1076894B (en) | 1958-06-20 | 1958-06-20 | X-ray contrast media |
| DESCH24639A DE1080266B (en) | 1958-06-20 | 1958-08-29 | X-ray contrast media |
| DESC025189 | 1958-12-13 | ||
| DESCH26697A DE1094931B (en) | 1958-06-20 | 1959-09-16 | X-ray contrast media |
| DESCH26696A DE1097085B (en) | 1958-06-20 | 1959-09-16 | X-ray contrast media |
| DESCH26755A DE1099696B (en) | 1958-06-20 | 1959-09-30 | X-ray contrast media |
| DESCH26802A DE1102345B (en) | 1958-06-20 | 1959-10-06 | X-ray contrast media |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB950321A true GB950321A (en) | 1964-02-26 |
Family
ID=27570712
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2248860A Expired GB950321A (en) | 1958-04-05 | 1960-06-27 | Derivatives of iodophenyl-propionic acids and improvements in and relating to x-ray contrast media |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB950321A (en) |
-
1960
- 1960-06-27 GB GB2248860A patent/GB950321A/en not_active Expired
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