GB949295A - Improvements in or relating to the preparation of certain substituted tetralones, and the compounds thus produced - Google Patents

Improvements in or relating to the preparation of certain substituted tetralones, and the compounds thus produced

Info

Publication number
GB949295A
GB949295A GB4690262A GB4690262A GB949295A GB 949295 A GB949295 A GB 949295A GB 4690262 A GB4690262 A GB 4690262A GB 4690262 A GB4690262 A GB 4690262A GB 949295 A GB949295 A GB 949295A
Authority
GB
United Kingdom
Prior art keywords
methoxy
carbon atoms
contain
relating
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4690262A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Publication of GB949295A publication Critical patent/GB949295A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
    • C07C49/755—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups a keto group being part of a condensed ring system with two or three rings, at least one ring being a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

6-methoxy -2- hydroxymethylenetetralone-1 of the formula: <FORM:0949295/C2/1> and its nuclear substitution products, are prepared by condensing 6-methoxytetralone-1 or a nuclear substitution product with an alkyl formate in the presence of a solid alkali-metal alcoholate and an N-disubstituted formamide or acetamide. The alkyl formate may contain 2-5 carbon atoms, the alkali-metal alcoholate may contain 1-4 carbon atoms, and the substituted formamide or acetamide may contain alkyl groups of up to 4 carbon atoms each, the alkyl groups being the same or different. The reaction may be effected at about atmospheric temperature in the presence or absence of a solvent, e.g. benzene or toluene. An example is given in which 6-methoxy -2- hydroxymethylene tetralone-1 is prepared from 6-methoxytetralone-1 and methyl formate in the presence of sodium methylate and dimethylformamide. 5-methyl -6-methoxy - 2 - hydroxymethylenetetralone-1 is similarly obtainable. Specification 904,508 is referred to.
GB4690262A 1961-12-27 1962-12-12 Improvements in or relating to the preparation of certain substituted tetralones, and the compounds thus produced Expired GB949295A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR883155A FR1346260A (en) 1961-12-27 1961-12-27 New process for the preparation of certain substituted tetralones

Publications (1)

Publication Number Publication Date
GB949295A true GB949295A (en) 1964-02-12

Family

ID=8769482

Family Applications (1)

Application Number Title Priority Date Filing Date
GB4690262A Expired GB949295A (en) 1961-12-27 1962-12-12 Improvements in or relating to the preparation of certain substituted tetralones, and the compounds thus produced

Country Status (5)

Country Link
BE (1) BE626562A (en)
CH (1) CH407974A (en)
DK (1) DK104055C (en)
FR (1) FR1346260A (en)
GB (1) GB949295A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104276935A (en) * 2014-09-26 2015-01-14 浙江大学宁波理工学院 4-(3-hydroxy propoxy)-8-hydroxyl-1-tetralone and synthesis method thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104276935A (en) * 2014-09-26 2015-01-14 浙江大学宁波理工学院 4-(3-hydroxy propoxy)-8-hydroxyl-1-tetralone and synthesis method thereof
CN104276935B (en) * 2014-09-26 2016-05-04 浙江大学宁波理工学院 4-(3-hydroxyl propoxyl group)-8-hydroxyl-ALPHA-tetralone and synthetic method

Also Published As

Publication number Publication date
CH407974A (en) 1966-02-28
DK104055C (en) 1966-03-28
FR1346260A (en) 1963-12-20
BE626562A (en) 1963-06-27

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