GB945506A - New steroid compounds and processes for their preparation - Google Patents
New steroid compounds and processes for their preparationInfo
- Publication number
- GB945506A GB945506A GB1196662A GB1196662A GB945506A GB 945506 A GB945506 A GB 945506A GB 1196662 A GB1196662 A GB 1196662A GB 1196662 A GB1196662 A GB 1196662A GB 945506 A GB945506 A GB 945506A
- Authority
- GB
- United Kingdom
- Prior art keywords
- bis
- pregnan
- hydroxymethylene
- diaralkylphosphato
- processes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Abstract
The invention comprises 20,20-bis-hydroxy-methylene -3a - phosphato -5b - pregnan -11- one having the formula: <FORM:0945506/C2/1> (where AC represents either a hydrogen atom or an acyl radical derived either from an organic carboxylic acid having from 1 to 18 carbon atoms or from a mineral acid), their non-toxic water-soluble salts, 3a -diaralkylphosphato -20,20-bis-hydroxymethylene - 5b - pregnan -11- ones and the ketonides thereof and processes for the preparation of the aforesaid compounds in which a lower ketonide of 3a -hydroxy -20,20-bis-hydroxymethylene -5b - pregnan -11- one is reacted with an aralkyl halogenophosphonate to form the corresponding ketonide of 3a -diaralkylphosphato -20,20-bis-hydroxymethylene -5b -pregnan -11- one, the protected 20,20-bis-hydroxymethylene groups of which are then liberated by acid hydrolysis to form the corresponding 3a -diaralkylphosphato -20,20-bis-hydroxymethylene -5b - pregnan -11- one, and the latter is subjected to hydro genolysis to yield 20,20-bis-hydroxymethylene -3a - phosphato -5b -pregnan -11- one. As aralkyl halogenophosphonate there may be used dibenzyl chlorophosphonate while hydrogenolysis may be effected by hydrogenation in the presence of palladium black. Specification 945,503 is referred to.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR857054A FR1368716A (en) | 1961-03-28 | 1961-03-28 | Bis-hydroxymethyl pregnane derivatives and method of preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
GB945506A true GB945506A (en) | 1964-01-02 |
Family
ID=8751882
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB1196662A Expired GB945506A (en) | 1961-03-28 | 1962-03-28 | New steroid compounds and processes for their preparation |
Country Status (5)
Country | Link |
---|---|
BE (1) | BE615643A (en) |
CH (1) | CH406210A (en) |
ES (1) | ES275827A1 (en) |
FR (1) | FR1368716A (en) |
GB (1) | GB945506A (en) |
-
1961
- 1961-03-28 FR FR857054A patent/FR1368716A/en not_active Expired
-
1962
- 1962-03-27 ES ES275827A patent/ES275827A1/en not_active Expired
- 1962-03-27 BE BE615643A patent/BE615643A/en unknown
- 1962-03-27 CH CH363262A patent/CH406210A/en unknown
- 1962-03-28 GB GB1196662A patent/GB945506A/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
CH406210A (en) | 1966-01-31 |
FR1368716A (en) | 1964-08-07 |
BE615643A (en) | 1962-09-27 |
ES275827A1 (en) | 1962-05-16 |
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