ES275827A1 - Procedure for the preparation of 3 alphaphosphate 11-oxo 2,20-bis-hydroxymethyl 5 betapregnan and its alkaline salts (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for the preparation of 3 alphaphosphate 11-oxo 2,20-bis-hydroxymethyl 5 betapregnan and its alkaline salts (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES275827A1
ES275827A1 ES275827A ES275827A ES275827A1 ES 275827 A1 ES275827 A1 ES 275827A1 ES 275827 A ES275827 A ES 275827A ES 275827 A ES275827 A ES 275827A ES 275827 A1 ES275827 A1 ES 275827A1
Authority
ES
Spain
Prior art keywords
bis
oxo
pregnane
hydroxymethyl
beta
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES275827A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Publication of ES275827A1 publication Critical patent/ES275827A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Process for the preparation of 3-alpha-phosphate 11-oxo-20,20-bis-hydroxymethyl-5-beta-pregnane of the formula: ** (See formula) ** and its alkali metal salts, especially the disodium salt of 3-alpha-phosphate 11-oxo-20,20-bis-hydroxymethyl-5-beta-pregnane, as well as, of its mineral or organic esters on the hydroxymethyl groups in 20, especially 3-alpha-phosphate. -oxo-20,20-bis-nitratomethyl-5-beta-pregnane, mainly characterized in that; the acetonide of 3alpha-hydroxy 11-oxo-20,20-bis-hydroxymethyl-5-beta-pregnane is subjected to the action of a functional derivative of phosphoric acid, such as a dibenzyl halogen-phosphonate, obtaining, in this case, the 3alpha - corresponding pregnane diphenyl phosphate; - the 20,20-bis-hydroxymethyl functions of the obtained 3alpha-dibenzylphosphate 11-oxo-20,20-bis-hydroxymethyl-5-beta-pregnane acetonide are unblocked, obtaining 3alpha-dibenzylphosphate 11-oxo 20,20-bis-liydroxymethyl 5beta Pregnane; - the dibenzylphosphate group is subjected to hydrogenolysis in 3 of the compound whose 20,20-bis-hydroxymethyl-5-beta-pregnane functions have been released, obtaining the 3-alpha-phosphate 11-oxo-20,20-bis-hydroxymethyl-5-beta-pregnane, which, if necessary, it can be converted into an alkaline salt, such as the 3alpha-phosphate 11-oxo-20,20-bis-hydroxymethyl-5-beta-pregnane disodium salt, or in a mineral or organic ester, such as 3-phosphate-3-phosphate. -oxo 20,20-bis-nitratomethyl 5beta-pregnane. (Machine-translation by Google Translate, not legally binding)
ES275827A 1961-03-28 1962-03-27 Procedure for the preparation of 3 alphaphosphate 11-oxo 2,20-bis-hydroxymethyl 5 betapregnan and its alkaline salts (Machine-translation by Google Translate, not legally binding) Expired ES275827A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR857054A FR1368716A (en) 1961-03-28 1961-03-28 Bis-hydroxymethyl pregnane derivatives and method of preparation

Publications (1)

Publication Number Publication Date
ES275827A1 true ES275827A1 (en) 1962-05-16

Family

ID=8751882

Family Applications (1)

Application Number Title Priority Date Filing Date
ES275827A Expired ES275827A1 (en) 1961-03-28 1962-03-27 Procedure for the preparation of 3 alphaphosphate 11-oxo 2,20-bis-hydroxymethyl 5 betapregnan and its alkaline salts (Machine-translation by Google Translate, not legally binding)

Country Status (5)

Country Link
BE (1) BE615643A (en)
CH (1) CH406210A (en)
ES (1) ES275827A1 (en)
FR (1) FR1368716A (en)
GB (1) GB945506A (en)

Also Published As

Publication number Publication date
CH406210A (en) 1966-01-31
BE615643A (en) 1962-09-27
FR1368716A (en) 1964-08-07
GB945506A (en) 1964-01-02

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