GB934713A - New steroid compounds and processes for their preparation - Google Patents
New steroid compounds and processes for their preparationInfo
- Publication number
- GB934713A GB934713A GB331963A GB331963A GB934713A GB 934713 A GB934713 A GB 934713A GB 331963 A GB331963 A GB 331963A GB 331963 A GB331963 A GB 331963A GB 934713 A GB934713 A GB 934713A
- Authority
- GB
- United Kingdom
- Prior art keywords
- acyloxy
- methyl
- hydroxy
- pregnan
- pregn
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention comprises 3#x-acyloxy-17a -acyloxy- 17a -hydroxy- 16a -methyl-pregna-11, 20-diones, 3#x,17-dihydroxy-16a -methyl-pregna-11,20 dione, 3#x-acyloxy-17a -hydroxy-16-methylene-pregnan-20-ones and 3#x-acyloxy-17a -hydroxy-16a -methyl-pregn-15-en-20-ones and processes for the preparation of 17a -hydroxy-16a -methyl-pregnan-20-ones having the formula:- <FORM:0934713/IV(a)/1> (wherein R represents either 2 hydrogen atoms or the oxygen atom of a ketone group and R1 represents either hydrogen or an acyl radical) in which a 16b -methyl-16a ,17a -epoxy-pregnan-20-one having the general formula <FORM:0934713/IV(a)/2> wherein R and R1 are as defined above, is treated with a dilute solution of a strong inorganic acid in an organic solvent, and the unsaturated derivative thus formed is thereafter reduced. As strong inorganic acid there may be used hydrochloric acid. The catalytic reduction may be effected with hydrogen in the presence of palladium black. The 16,17-epoxy starting compound may be obtained by thermolysis of the 16(C)a , 17(N)a -pyrazoline of 3#x-acyloxy-pregn-16-en-20-one to obtain 3#x-acyloxy-16-methyl-pregn-16-en-20-one and epoxidising this compound with hydrogen peroxide in alkaline medium. Specification 934,701 also is referred to
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR783552A FR1222598A (en) | 1959-01-08 | 1959-01-08 | Process for the preparation of methylated and hydroxylated ketosteroids of the pregnane series |
Publications (1)
Publication Number | Publication Date |
---|---|
GB934713A true GB934713A (en) | 1963-08-21 |
Family
ID=8709963
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB331963A Expired GB934713A (en) | 1959-01-08 | 1960-01-08 | New steroid compounds and processes for their preparation |
GB81160A Expired GB934702A (en) | 1959-01-08 | 1960-01-08 | Improvements in or relating to steroids |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB81160A Expired GB934702A (en) | 1959-01-08 | 1960-01-08 | Improvements in or relating to steroids |
Country Status (6)
Country | Link |
---|---|
BE (1) | BE586333A (en) |
CH (1) | CH400143A (en) |
DE (1) | DE1418945C3 (en) |
ES (1) | ES254791A1 (en) |
FR (1) | FR1222598A (en) |
GB (2) | GB934713A (en) |
-
1959
- 1959-01-08 FR FR783552A patent/FR1222598A/en not_active Expired
-
1960
- 1960-01-05 DE DE19601418945 patent/DE1418945C3/en not_active Expired
- 1960-01-07 CH CH4060A patent/CH400143A/en unknown
- 1960-01-07 ES ES0254791A patent/ES254791A1/en not_active Expired
- 1960-01-07 BE BE586333A patent/BE586333A/en unknown
- 1960-01-08 GB GB331963A patent/GB934713A/en not_active Expired
- 1960-01-08 GB GB81160A patent/GB934702A/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
BE586333A (en) | 1960-07-07 |
FR1222598A (en) | 1960-06-10 |
GB934702A (en) | 1963-08-21 |
DE1418945C3 (en) | 1973-09-13 |
DE1418945A1 (en) | 1968-12-19 |
DE1418945B2 (en) | 1973-02-15 |
ES254791A1 (en) | 1960-05-16 |
CH400143A (en) | 1965-10-15 |
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