GB929788A - Azepine derivatives and processes for producing same - Google Patents
Azepine derivatives and processes for producing sameInfo
- Publication number
- GB929788A GB929788A GB2104659A GB2104659A GB929788A GB 929788 A GB929788 A GB 929788A GB 2104659 A GB2104659 A GB 2104659A GB 2104659 A GB2104659 A GB 2104659A GB 929788 A GB929788 A GB 929788A
- Authority
- GB
- United Kingdom
- Prior art keywords
- salts
- inorganic
- compounds
- general formula
- organic acids
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 3
- 150000001538 azepines Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 150000007522 mineralic acids Chemical class 0.000 abstract 3
- 150000007524 organic acids Chemical class 0.000 abstract 3
- 235000005985 organic acids Nutrition 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- 150000003512 tertiary amines Chemical class 0.000 abstract 2
- 229910021529 ammonia Inorganic materials 0.000 abstract 1
- 229940124326 anaesthetic agent Drugs 0.000 abstract 1
- 230000003444 anaesthetic effect Effects 0.000 abstract 1
- 229940035676 analgesics Drugs 0.000 abstract 1
- 239000000730 antalgic agent Substances 0.000 abstract 1
- 230000003266 anti-allergic effect Effects 0.000 abstract 1
- 230000001754 anti-pyretic effect Effects 0.000 abstract 1
- 239000000043 antiallergic agent Substances 0.000 abstract 1
- 229940082988 antihypertensives serotonin antagonists Drugs 0.000 abstract 1
- 239000002221 antipyretic Substances 0.000 abstract 1
- 229940125716 antipyretic agent Drugs 0.000 abstract 1
- 239000003420 antiserotonin agent Substances 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 239000000544 cholinesterase inhibitor Substances 0.000 abstract 1
- 238000005984 hydrogenation reaction Methods 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 229940125723 sedative agent Drugs 0.000 abstract 1
- 239000000932 sedative agent Substances 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
The invention comprises: (a) compounds of the general formula <FORM:0929788/IV(a)/1> (wherein X represents -CH2-CH2- or -CH=CH-, Y and Z represent hydrogen or halogen atoms or methyl or ethyl groups, and represents a hydrogen atom or an alkyl or aralkyl radical) and their salts with inorganic and organic acids; (b) the preparation thereof by reduction or hydrogenation (the latter preferably in the presence of ammonia) of compounds of the general formula <FORM:0929788/IV(a)/2> followed, if desired, by conversion of the products into salts with inorganic or organic acids; and (c) the combination of process (b) with the preparation of the starting materials by the process of Specification 929,789. The products may be dialkylated at the primary amino group, and both the primary and the tertiary amines have pharmaceutical uses (see Group VI).ALSO:Compounds of the general formula <FORM:0929788/VI/1> (wherein X represents -CH2-CH2- or -CH =CH-, Y and Z represent hydrogen or halogen atoms or methyl or ethyl groups, and R represents a hydrogen atom or an alkyl or aralkyl radical), and their salts with inorganic and organic acids, are useful as cholinesterase inhibitors, antiallergics, antipyretics, serotonin antagonists, and potentiators of analgesics and anaesthetics. The tertiary amines derived therefrom by dialkylation are useful for similar purposes and also as sedatives. Specification 929,789 is referred to.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH6095458A CH368495A (en) | 1958-06-24 | 1958-06-24 | Process for the production of azepine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB929788A true GB929788A (en) | 1963-06-26 |
Family
ID=4523304
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB966463A Expired GB929789A (en) | 1958-06-24 | 1959-06-19 | Azepine derivatives and processes for producing same |
| GB2104659A Expired GB929788A (en) | 1958-06-24 | 1959-06-19 | Azepine derivatives and processes for producing same |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB966463A Expired GB929789A (en) | 1958-06-24 | 1959-06-19 | Azepine derivatives and processes for producing same |
Country Status (2)
| Country | Link |
|---|---|
| CH (1) | CH368495A (en) |
| GB (2) | GB929789A (en) |
-
1958
- 1958-06-24 CH CH6095458A patent/CH368495A/en unknown
-
1959
- 1959-06-19 GB GB966463A patent/GB929789A/en not_active Expired
- 1959-06-19 GB GB2104659A patent/GB929788A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| CH368495A (en) | 1963-04-15 |
| GB929789A (en) | 1963-06-26 |
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