GB919399A - Derivatives of nicotinic acid and a process for their production - Google Patents

Derivatives of nicotinic acid and a process for their production

Info

Publication number
GB919399A
GB919399A GB14785/61A GB1478561A GB919399A GB 919399 A GB919399 A GB 919399A GB 14785/61 A GB14785/61 A GB 14785/61A GB 1478561 A GB1478561 A GB 1478561A GB 919399 A GB919399 A GB 919399A
Authority
GB
United Kingdom
Prior art keywords
formaldehyde
reaction
nicotinic acid
amide
nicotinoylaminomethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB14785/61A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eprova AG
Original Assignee
Eprova AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eprova AG filed Critical Eprova AG
Publication of GB919399A publication Critical patent/GB919399A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)

Abstract

The invention comprises compounds of the formula <FORM:0919399/IV (b)/1> (wherein -NR1R2 is dialkylamino, alkyiaralkylamino or diaralkylamino, or R1 and R2 are, together with the nitrogen atom, linked to form a saturated heterocyclic radical which may contain other hetero atoms which when a nitrogen atom may be further substituted by an alkyl group of at most 3 carbon atoms or by a nicotinoylaminomethyl group) and salts thereof with organic and inorganic acids; and their preparation by reacting nicotinic acid amide directly or in stages with formaldehyde and the secondary amine NHR1R2. The amide may be reacted with formaldehyde (or a compound yielding it) and the amine simultaneously, or it may first be converted into the N-hydroxymethyl derivative or an ether or thioether thereof, or into the N-diethylaminomethyl derivative, by reaction with formaldehyde (or compounds yielding it) and if necessary reaction with alcohols, thioalcohols or with diethylamine, and the intermediate product so obtained, if necessary, further reacted with the appropriate secondary amine. 1,4-Bis(nicotinoylaminomethyl)-piperazine is prepared by heating 2 mols of nicotinic acid-N-(hydroxymethyl)-amide with 1 mol of piperazine. Detailed examples are given. N-(1,2-diphenylethyl)-N-methylamine is prepared by reaction of benzalmethylamine with benzyl magnesium chloride and subsequent hydrolysis.
GB14785/61A 1960-06-27 1961-04-24 Derivatives of nicotinic acid and a process for their production Expired GB919399A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH722460A CH392507A (en) 1960-06-27 1960-06-27 Process for the preparation of nicotinic acid aminomethylamides

Publications (1)

Publication Number Publication Date
GB919399A true GB919399A (en) 1963-02-27

Family

ID=4321798

Family Applications (1)

Application Number Title Priority Date Filing Date
GB14785/61A Expired GB919399A (en) 1960-06-27 1961-04-24 Derivatives of nicotinic acid and a process for their production

Country Status (3)

Country Link
CH (1) CH392507A (en)
FR (1) FR1196M (en)
GB (1) GB919399A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0172545A1 (en) * 1984-08-20 1986-02-26 Nippon Kayaku Co., Ltd. 3-or 4-pyridinecarboxamide-derivates and their use as bactericides

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5675474A (en) * 1979-11-22 1981-06-22 Chugai Pharmaceut Co Ltd Nicotinamide derivative and medicine containing the same

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0172545A1 (en) * 1984-08-20 1986-02-26 Nippon Kayaku Co., Ltd. 3-or 4-pyridinecarboxamide-derivates and their use as bactericides

Also Published As

Publication number Publication date
FR1196M (en) 1962-03-19
CH392507A (en) 1965-05-31

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