GB918446A - Improvements in or relating to the preparation of hydroxocobalamin - Google Patents
Improvements in or relating to the preparation of hydroxocobalaminInfo
- Publication number
- GB918446A GB918446A GB1767861A GB1767861A GB918446A GB 918446 A GB918446 A GB 918446A GB 1767861 A GB1767861 A GB 1767861A GB 1767861 A GB1767861 A GB 1767861A GB 918446 A GB918446 A GB 918446A
- Authority
- GB
- United Kingdom
- Prior art keywords
- hydroxocobalamin
- added
- ferrous
- cyanocobalamin
- medium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H23/00—Compounds containing boron, silicon, or a metal, e.g. chelates, vitamin B12
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Saccharide Compounds (AREA)
Abstract
Hydroxocobalamin is obtained by reducing cyanocobalamin in the absence of a catalyst in an acid medium of pH of 1.5 to 2.0 by means of ferrous sulphate followed by oxidation in a medium of a pH equal to or greater than 8. In an example ferrous chloride in dilute hydrochloric acid is added to aqueous cyanocobalamin to give a pH of 1.8. The mixture is then heated to a temperature below 50 DEG C. while being concentrated in vacuo. Soda is then added to bring the pH to 8.5 and the ferrous oxide precipitate recovered. The filtrate is then oxidised by bubbling with air or oxygen, diluted with acetone and the hydroxocobalamin separated and purified by chromatography.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MC229A MC309A1 (en) | 1960-06-21 | 1960-06-21 | The transformation of cyanocobalamin (b12) into hydroxocobalamin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB918446A true GB918446A (en) | 1963-02-13 |
Family
ID=19737423
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1767861A Expired GB918446A (en) | 1960-06-21 | 1961-05-15 | Improvements in or relating to the preparation of hydroxocobalamin |
Country Status (5)
| Country | Link |
|---|---|
| BE (1) | BE604955A (en) |
| CH (1) | CH397706A (en) |
| ES (1) | ES267046A1 (en) |
| GB (1) | GB918446A (en) |
| MC (1) | MC309A1 (en) |
-
1960
- 1960-06-21 MC MC229A patent/MC309A1/en unknown
-
1961
- 1961-05-02 CH CH511161A patent/CH397706A/en unknown
- 1961-05-02 ES ES0267046A patent/ES267046A1/en not_active Expired
- 1961-05-15 GB GB1767861A patent/GB918446A/en not_active Expired
- 1961-06-13 BE BE604955A patent/BE604955A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BE604955A (en) | 1961-12-13 |
| ES267046A1 (en) | 1961-11-01 |
| CH397706A (en) | 1965-08-31 |
| MC309A1 (en) | 1962-03-21 |
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