GB915303A - Pyrrolo[2,3-d]pyrimidine derivatives and the manufacture thereof - Google Patents
Pyrrolo[2,3-d]pyrimidine derivatives and the manufacture thereofInfo
- Publication number
- GB915303A GB915303A GB8013/59A GB801359A GB915303A GB 915303 A GB915303 A GB 915303A GB 8013/59 A GB8013/59 A GB 8013/59A GB 801359 A GB801359 A GB 801359A GB 915303 A GB915303 A GB 915303A
- Authority
- GB
- United Kingdom
- Prior art keywords
- group
- hydrogen atom
- alkyl
- pyrrolo
- general formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000004943 pyrrolo[2,3-d]pyrimidines Chemical class 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- BPTCCCTWWAUJRK-UHFFFAOYSA-N 4-chloro-7h-pyrrolo[2,3-d]pyrimidine Chemical compound ClC1=NC=NC2=C1C=CN2 BPTCCCTWWAUJRK-UHFFFAOYSA-N 0.000 abstract 1
- 208000001953 Hypotension Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 150000001450 anions Chemical class 0.000 abstract 1
- 230000001773 anti-convulsant effect Effects 0.000 abstract 1
- 239000001961 anticonvulsive agent Substances 0.000 abstract 1
- 229960003965 antiepileptics Drugs 0.000 abstract 1
- 239000002220 antihypertensive agent Substances 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000004181 carboxyalkyl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000004983 dialkoxyalkyl group Chemical group 0.000 abstract 1
- 125000004985 dialkyl amino alkyl group Chemical group 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 239000003326 hypnotic agent Substances 0.000 abstract 1
- 230000000147 hypnotic effect Effects 0.000 abstract 1
- 208000021822 hypotensive Diseases 0.000 abstract 1
- 230000001077 hypotensive effect Effects 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 239000003158 myorelaxant agent Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- -1 pyrrolidino, piperidino, morpholino Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000003204 tranquilizing agent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US72110458A | 1958-03-13 | 1958-03-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB915303A true GB915303A (en) | 1963-01-09 |
Family
ID=24896553
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB8013/59A Expired GB915303A (en) | 1958-03-13 | 1959-03-09 | Pyrrolo[2,3-d]pyrimidine derivatives and the manufacture thereof |
| GB32973/61A Expired GB915304A (en) | 1958-03-13 | 1959-03-09 | Pyrrolo[2,3-d]pyrimidine derivatives |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB32973/61A Expired GB915304A (en) | 1958-03-13 | 1959-03-09 | Pyrrolo[2,3-d]pyrimidine derivatives |
Country Status (3)
| Country | Link |
|---|---|
| ES (1) | ES247857A1 (en:Method) |
| FR (1) | FR607M (en:Method) |
| GB (2) | GB915303A (en:Method) |
Cited By (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4007187A (en) * | 1973-10-02 | 1977-02-08 | Delalande S.A. | Furo (2,3d) pyrimidines |
| WO1999062518A1 (en) * | 1998-06-02 | 1999-12-09 | Osi Pharmaceuticals, Inc. | PYRROLO[2,3d]PYRIMIDINE COMPOSITIONS AND THEIR USE |
| US6096749A (en) * | 1994-05-03 | 2000-08-01 | Novartis Corporation | Pyrrolopyrimidine derivatives having pharmacological activity |
| US6664252B2 (en) | 1999-12-02 | 2003-12-16 | Osi Pharmaceuticals, Inc. | 4-aminopyrrolo[2,3-d]pyrimidine compounds specific to adenosine A2a receptor and uses thereof |
| US6673802B2 (en) | 2000-12-01 | 2004-01-06 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A3 receptor and uses thereof |
| US6680322B2 (en) | 1999-12-02 | 2004-01-20 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A1 receptors and uses thereof |
| US6680324B2 (en) | 2000-12-01 | 2004-01-20 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A1 receptors and uses thereof |
| US6686366B1 (en) | 1998-06-02 | 2004-02-03 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A3 receptor and uses thereof |
| JP2005504847A (ja) * | 2001-10-04 | 2005-02-17 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | ピリミジン誘導体 |
| US6878716B1 (en) | 1998-06-02 | 2005-04-12 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A1 receptor and uses thereof |
| US7160890B2 (en) | 1999-12-02 | 2007-01-09 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A3 receptor and uses thereof |
| US7250420B2 (en) | 2002-11-26 | 2007-07-31 | Pfizer Inc. | Method of treatment of transplant rejection |
| US7265221B2 (en) | 1999-12-10 | 2007-09-04 | Pfizer, Inc. | Pyrrolo[2,3-d]pyrimidine compounds |
| JP2007284455A (ja) * | 1998-06-19 | 2007-11-01 | Pfizer Prod Inc | ピロロ［２．３−ｄ］ピリミジン化合物 |
| WO2007084667A3 (en) * | 2006-01-19 | 2007-12-06 | Osi Pharmaceutical Inc | Fused heterobicyclic kinase inhibitors |
| US7501407B2 (en) | 2001-12-20 | 2009-03-10 | Osi Pharmaceuticals, Inc. | Pyrimidine A2B selective antagonist compounds, their synthesis and use |
| US7504407B2 (en) | 2001-11-30 | 2009-03-17 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A1 and A3 receptors and uses thereof |
| US7569569B2 (en) | 1998-06-19 | 2009-08-04 | Pfizer Inc. | Pyrrolo[2,3-d]pyrimidine compounds |
| US7645754B2 (en) | 2001-12-20 | 2010-01-12 | Osi Pharmaceuticals, Inc. | Pyrrolopyrimidine A2B selective antagonist compounds, their synthesis and use |
| US8133899B2 (en) | 2008-08-20 | 2012-03-13 | Pfizer Inc. | Pyrrolo[2,3-d]pyrimidine compounds |
| US12202834B2 (en) | 2019-01-29 | 2025-01-21 | Vationpharma B.V. | Solid state forms of oclacitinib maleate |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3311628A (en) * | 1965-03-09 | 1967-03-28 | Bristol Myers Co | Derivatives of pyrrolo [2, 3-d] pyrimidine |
-
1959
- 1959-03-09 GB GB8013/59A patent/GB915303A/en not_active Expired
- 1959-03-09 GB GB32973/61A patent/GB915304A/en not_active Expired
- 1959-04-12 ES ES0247857A patent/ES247857A1/es not_active Expired
-
1961
- 1961-08-31 FR FR837423A patent/FR607M/fr active Active
Cited By (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4007187A (en) * | 1973-10-02 | 1977-02-08 | Delalande S.A. | Furo (2,3d) pyrimidines |
| US6096749A (en) * | 1994-05-03 | 2000-08-01 | Novartis Corporation | Pyrrolopyrimidine derivatives having pharmacological activity |
| US7429574B2 (en) | 1998-06-02 | 2008-09-30 | Osi Pharmaceuticals, Inc. | 4-heterocyclo-pyrrolo[2,3d] pyrimidine compositions and their use |
| JP2002516861A (ja) * | 1998-06-02 | 2002-06-11 | オーエスアイ・ファーマスーティカルズ・インコーポレーテッド | ピロロ［２，３ｄ］ピリミジン組成物およびその使用 |
| EP2011499A3 (en) * | 1998-06-02 | 2010-10-20 | OSI Pharmaceuticals, Inc. | Pyrrolo[2,3d]Pyrimidine compositions and their use |
| CZ302486B6 (cs) * | 1998-06-02 | 2011-06-15 | Osi Pharmaceuticals, Inc. | N-6-Substituovaný 7-deazapurin, zpusob jeho prípravy a farmaceutická kompozice s jeho obsahem |
| WO1999062518A1 (en) * | 1998-06-02 | 1999-12-09 | Osi Pharmaceuticals, Inc. | PYRROLO[2,3d]PYRIMIDINE COMPOSITIONS AND THEIR USE |
| AP1411A (en) * | 1998-06-02 | 2005-05-10 | Osi Pharm Inc | Pyrrolo[2,3d] pyrimidine compositions and their use. |
| US6686366B1 (en) | 1998-06-02 | 2004-02-03 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A3 receptor and uses thereof |
| US6800633B2 (en) | 1998-06-02 | 2004-10-05 | Osi Pharmaceuticals, Inc. | Pyrrolo[2,3d]pyrimidine compositions and their use |
| US6878716B1 (en) | 1998-06-02 | 2005-04-12 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A1 receptor and uses thereof |
| US7687507B2 (en) | 1998-06-19 | 2010-03-30 | Pfizer Inc. | Pyrrolo[2,3-d]pyrimidine compounds |
| JP2007284455A (ja) * | 1998-06-19 | 2007-11-01 | Pfizer Prod Inc | ピロロ［２．３−ｄ］ピリミジン化合物 |
| US7569569B2 (en) | 1998-06-19 | 2009-08-04 | Pfizer Inc. | Pyrrolo[2,3-d]pyrimidine compounds |
| JP2012041365A (ja) * | 1998-06-19 | 2012-03-01 | Pfizer Products Inc | ピロロ［２．３−ｄ］ピリミジン化合物 |
| US7160890B2 (en) | 1999-12-02 | 2007-01-09 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A3 receptor and uses thereof |
| US6664252B2 (en) | 1999-12-02 | 2003-12-16 | Osi Pharmaceuticals, Inc. | 4-aminopyrrolo[2,3-d]pyrimidine compounds specific to adenosine A2a receptor and uses thereof |
| US6680322B2 (en) | 1999-12-02 | 2004-01-20 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A1 receptors and uses thereof |
| USRE41783E1 (en) | 1999-12-10 | 2010-09-28 | Pfizer Inc. | Pyrrolo[2,3-D]pyrimidine compounds |
| US7601727B2 (en) | 1999-12-10 | 2009-10-13 | Pfizer, Inc. | Pyrrolo[2,3-d]pyrimidine compounds |
| US7265221B2 (en) | 1999-12-10 | 2007-09-04 | Pfizer, Inc. | Pyrrolo[2,3-d]pyrimidine compounds |
| US7842699B2 (en) | 1999-12-10 | 2010-11-30 | Pfizer Inc. | Pyrrolo[2,3-D]pyrimidine compounds |
| US6680324B2 (en) | 2000-12-01 | 2004-01-20 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A1 receptors and uses thereof |
| US7598252B2 (en) | 2000-12-01 | 2009-10-06 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A, receptors and uses thereof |
| US6673802B2 (en) | 2000-12-01 | 2004-01-06 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A3 receptor and uses thereof |
| JP4782376B2 (ja) * | 2001-10-04 | 2011-09-28 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | ピリミジン誘導体 |
| JP2005504847A (ja) * | 2001-10-04 | 2005-02-17 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | ピリミジン誘導体 |
| US7504407B2 (en) | 2001-11-30 | 2009-03-17 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A1 and A3 receptors and uses thereof |
| US7645754B2 (en) | 2001-12-20 | 2010-01-12 | Osi Pharmaceuticals, Inc. | Pyrrolopyrimidine A2B selective antagonist compounds, their synthesis and use |
| US7501407B2 (en) | 2001-12-20 | 2009-03-10 | Osi Pharmaceuticals, Inc. | Pyrimidine A2B selective antagonist compounds, their synthesis and use |
| US7250420B2 (en) | 2002-11-26 | 2007-07-31 | Pfizer Inc. | Method of treatment of transplant rejection |
| WO2007084667A3 (en) * | 2006-01-19 | 2007-12-06 | Osi Pharmaceutical Inc | Fused heterobicyclic kinase inhibitors |
| JP2009523812A (ja) * | 2006-01-19 | 2009-06-25 | オーエスアイ・ファーマスーティカルズ・インコーポレーテッド | 融合へテロ二環式キナーゼ阻害剤 |
| US8133899B2 (en) | 2008-08-20 | 2012-03-13 | Pfizer Inc. | Pyrrolo[2,3-d]pyrimidine compounds |
| US8987283B2 (en) | 2008-08-20 | 2015-03-24 | Zoetis Llc | Pyrrolo[2,3-D]pyrimidine compounds |
| US9161939B2 (en) | 2008-08-20 | 2015-10-20 | Zoetis Services Llc | Pyrrolo[2,3-d]pyrimidine compounds |
| US9271981B2 (en) | 2008-08-20 | 2016-03-01 | Zoetis Services Llc | Pyrrolo[2,3-D]pyrimidine compounds |
| US12202834B2 (en) | 2019-01-29 | 2025-01-21 | Vationpharma B.V. | Solid state forms of oclacitinib maleate |
Also Published As
| Publication number | Publication date |
|---|---|
| ES247857A1 (es) | 1959-08-16 |
| FR607M (en:Method) | 1961-06-19 |
| GB915304A (en) | 1963-01-09 |
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