GB906399A - Injectable solutions comprising benzothiadiazine-1:1-dioxide diuretics - Google Patents
Injectable solutions comprising benzothiadiazine-1:1-dioxide diureticsInfo
- Publication number
- GB906399A GB906399A GB144260A GB144260A GB906399A GB 906399 A GB906399 A GB 906399A GB 144260 A GB144260 A GB 144260A GB 144260 A GB144260 A GB 144260A GB 906399 A GB906399 A GB 906399A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- benzothiadiazine
- dioxide
- amides
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000002934 diuretic Substances 0.000 title abstract 3
- 229940030606 diuretics Drugs 0.000 title abstract 2
- -1 N-substituted amide Chemical class 0.000 abstract 6
- 150000001408 amides Chemical class 0.000 abstract 3
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000001188 haloalkyl group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- UHOVQNZJYSORNB-UHFFFAOYSA-N monobenzene Natural products C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 2
- WQKHERPPDYPMNX-UHFFFAOYSA-N 6-chloro-3,4-dihydro-2h-naphthalen-1-one Chemical compound O=C1CCCC2=CC(Cl)=CC=C21 WQKHERPPDYPMNX-UHFFFAOYSA-N 0.000 abstract 1
- LRFVTYWOQMYALW-UHFFFAOYSA-N 9H-xanthine Chemical class O=C1NC(=O)NC2=C1NC=N2 LRFVTYWOQMYALW-UHFFFAOYSA-N 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000001340 alkali metals Chemical class 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000003368 amide group Chemical group 0.000 abstract 1
- 239000003963 antioxidant agent Substances 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 235000013877 carbamide Nutrition 0.000 abstract 1
- 125000000068 chlorophenyl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 150000001991 dicarboxylic acids Chemical class 0.000 abstract 1
- 235000014113 dietary fatty acids Nutrition 0.000 abstract 1
- 230000001882 diuretic effect Effects 0.000 abstract 1
- 239000000194 fatty acid Substances 0.000 abstract 1
- 229930195729 fatty acid Natural products 0.000 abstract 1
- 150000004665 fatty acids Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- QZUPTXGVPYNUIT-UHFFFAOYSA-N isophthalamide Chemical class NC(=O)C1=CC=CC(C(N)=O)=C1 QZUPTXGVPYNUIT-UHFFFAOYSA-N 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- NAYYNDKKHOIIOD-UHFFFAOYSA-N phthalamide Chemical class NC(=O)C1=CC=CC=C1C(N)=O NAYYNDKKHOIIOD-UHFFFAOYSA-N 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
- 239000003381 stabilizer Substances 0.000 abstract 1
- MHSKRLJMQQNJNC-UHFFFAOYSA-N terephthalamide Chemical class NC(=O)C1=CC=C(C(N)=O)C=C1 MHSKRLJMQQNJNC-UHFFFAOYSA-N 0.000 abstract 1
- 150000003585 thioureas Chemical class 0.000 abstract 1
- 125000003944 tolyl group Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
- 150000003672 ureas Chemical class 0.000 abstract 1
- 229920002554 vinyl polymer Polymers 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
- A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/15—Six-membered rings
- C07D285/16—Thiadiazines; Hydrogenated thiadiazines
- C07D285/18—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines
- C07D285/20—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems
- C07D285/22—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D285/24—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with oxygen atoms directly attached to the ring sulfur atom
- C07D285/26—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with oxygen atoms directly attached to the ring sulfur atom substituted in position 6 or 7 by sulfamoyl or substituted sulfamoyl radicals
- C07D285/28—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with oxygen atoms directly attached to the ring sulfur atom substituted in position 6 or 7 by sulfamoyl or substituted sulfamoyl radicals with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached in position 3
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78668859A | 1959-01-14 | 1959-01-14 | |
| US81800459A | 1959-06-04 | 1959-06-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB906399A true GB906399A (en) | 1962-09-19 |
Family
ID=27120564
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB144260A Expired GB906399A (en) | 1959-01-14 | 1960-01-14 | Injectable solutions comprising benzothiadiazine-1:1-dioxide diuretics |
Country Status (4)
| Country | Link |
|---|---|
| BE (1) | BE586530A (enrdf_load_html_response) |
| DE (1) | DE1211751B (enrdf_load_html_response) |
| GB (1) | GB906399A (enrdf_load_html_response) |
| NL (1) | NL247297A (enrdf_load_html_response) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2320101A1 (fr) * | 1975-08-04 | 1977-03-04 | Geistlich Soehne Ag | Solutions a action antibacterienne amelioree a base de derives de thiadiazine |
| EP0154009A1 (en) * | 1983-12-09 | 1985-09-11 | Euro-Celtique S.A. | Use of a thiazide diuretic for the manufacture of a non-diuretic antihypertensive medicament |
-
0
- NL NL247297D patent/NL247297A/xx unknown
-
1960
- 1960-01-09 DE DEC20531A patent/DE1211751B/de active Pending
- 1960-01-13 BE BE586530A patent/BE586530A/fr unknown
- 1960-01-14 GB GB144260A patent/GB906399A/en not_active Expired
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2320101A1 (fr) * | 1975-08-04 | 1977-03-04 | Geistlich Soehne Ag | Solutions a action antibacterienne amelioree a base de derives de thiadiazine |
| EP0154009A1 (en) * | 1983-12-09 | 1985-09-11 | Euro-Celtique S.A. | Use of a thiazide diuretic for the manufacture of a non-diuretic antihypertensive medicament |
Also Published As
| Publication number | Publication date |
|---|---|
| DE1211751B (de) | 1966-03-03 |
| NL247297A (enrdf_load_html_response) | |
| BE586530A (fr) | 1960-07-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES8103734A1 (es) | Procedimiento para preparar nuevos derivados de piperidina | |
| ES2051727T3 (es) | Procedimiento para la preparacion de acidos 2-arilpropionicos. | |
| DE3369134D1 (en) | Substituted 5-trifluoromethyl-1,3,4-thiadiazol-2-yl oxiacetic-acid amides, process for their preparation and their use as herbicides | |
| KR840008016A (ko) | 융합 이미다졸 화합물의 제조방법 | |
| KR830006219A (ko) | 아미노산 유도체의 제조방법 | |
| ES431513A1 (es) | Procedimiento para la preparacion de 2 - (heteroaril-metil)-5,9 beta - dialcohil-6,7-benzomorfanos. | |
| ES262575A1 (es) | Procedimiento de activaciën de agentes herbicidas | |
| JPS6456673A (en) | Novel pyridonecarboxylic acid derivative, its ester and salt | |
| GB1053085A (enrdf_load_html_response) | ||
| KR830009067A (ko) | 2-치환된 하이드록시이미노-2(5-아미노-1,2,4-티아디아졸-3-일) 초산 혹은 그것의 염 그리고 그것의 중간생성물의 제조방법 | |
| GB906399A (en) | Injectable solutions comprising benzothiadiazine-1:1-dioxide diuretics | |
| ES265136A1 (es) | Procedimiento de obtenciën de derivados de tiaxantena | |
| IE38329B1 (en) | Carboxyl and tetrazolyl derivatives of thioxanthones methods for their preparation and compisitions containing them | |
| KR900003179A (ko) | 벤조디아제핀 화합물 및 약제로서의 이의 용도 | |
| KR850000455A (ko) | 세팔로스포린 에스테르 유도체의 제조방법 | |
| ES479570A1 (es) | Un procedimiento para la preparacion de derivaciones 7 &-me-toxicefalosporina. | |
| KR880012544A (ko) | 벤젠설폰아미드 유도체 및 그의 제조방법 | |
| ATE70531T1 (de) | Carbacyclinester, verfahren zu ihrer herstellung und ihre verwendung in der medizin. | |
| GB1436230A (en) | Method of converting radiation of frequency higher than that of visible light to radiation in the visible range | |
| ES430900A1 (es) | Un procedimiento para la preparacion de acidos (1-oxo-2-arilo tienil-2-sustituido-5-indaniloxi (o tio) alcanoicos y derivados de los mismos.. | |
| ES460117A1 (es) | Procedimiento para la preparacion de nuevos n-bencil-aminoa-cidos que contienen azufre. | |
| HUT45016A (en) | Herbicides containing as active substance derivatives of piridil-phenil-ether and process for production of these derivatives | |
| KR850000456A (ko) | 세팔로스포린 에스테르의 제조방법 | |
| ES449446A1 (es) | Un procedimiento para la produccion de acidos 1-oxo-1h-6-pi-peridinogicamente activos y esteres de los mismos. | |
| ES8606359A1 (es) | Procedimiento para preparar esteres de cefalosporinas |