GB901311A - Pyridylamino lower alkane derivatives and processes for preparing them - Google Patents

Pyridylamino lower alkane derivatives and processes for preparing them

Info

Publication number
GB901311A
GB901311A GB2554159A GB2554159A GB901311A GB 901311 A GB901311 A GB 901311A GB 2554159 A GB2554159 A GB 2554159A GB 2554159 A GB2554159 A GB 2554159A GB 901311 A GB901311 A GB 901311A
Authority
GB
United Kingdom
Prior art keywords
carbon atom
group
carbamoyloxy
substituted
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2554159A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Irwin Neisler and Co
Original Assignee
Irwin Neisler and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Irwin Neisler and Co filed Critical Irwin Neisler and Co
Publication of GB901311A publication Critical patent/GB901311A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention comprises secondary and tertiary amino - lower - alkanes having a hydroxy, lower-alkanoyloxy, carbamoyloxy or N-mono- or di - lower - alkyl - carbamoyloxy group attached to a carbon atom of the alkane chain, which carbon atom is separated from the amino nitrogen atom by at least one carbon atom and carries also at least one monocarbocyclic group, optionally substituted by halogens or lower alkyl or alkoxy groups, the amino nitrogen atom being substituted by a pyridyl residue attached through a carbon atom of the pyridine ring and optionally carrying one or more simple substituents not adversely affecting the pharmocological properties of the compound (e.g. halogen, methyl, methoxy, nitro or trifluoromethyl) and, when tertiary, also by a lower alkyl group, and the term "lower" denoting the presence of not more than 6 carbon atoms, and their acid addition and quaternary ammonium salts, and the preparation thereof by: (a) reduction of the compounds of Specification 901,312 (or their homologues) followed, if desired, by esterification of the free hydroxy group; (b) reaction of a monocarbocyclic-substituted lower alkanolamine with a halopyridine; (c) reduction of the oxazolidine formed by reacting a (b -hydroxy - b - monocarbocyclic-lower-alkyl-secondary-amino)-pyridine derivative with a lower aldehyde; (d) reaction of a monocarbocyclic-substituted ethylene oxide with an aminopyridine in the presence of one equivalent of a basic condensing agent; or (e) (for the carbamoyloxy compounds) reaction of the free hydroxy compounds with phosgene and the resulting intermediates with ammonia. The products have analgesic, barbituratepotentiating, interneuronal blocking and antifibrillatory properties.ALSO:As analgesic, barbiturate-potentiating, interneuronal blocking and anti-fibrillatory agents may be employed secondary or tertiary aminolower-alkanes having a hydroxy, lower-alkanoyloxy, carbamoyloxy or N-mono- or di-lower-alkyl-carbamoyloxy group attached to a carbon atom of the alkane chain, which carbon atom is separated from the amino nitrogen atom by at least one carbon atom and carries also at least one mono-carbocylic group, optionally substituted by halogens or lower alkyl or alkoxy groups, the amino nitrogen atom being substituted by a pyridyl residue attached through a carbon atom of the pyridine ring and optionally carrying one or more simple substituents not adversely affecting the pharmacological properties of the compound, and, when tertiary, also by a lower alkyl group, and the term "lower" denoting the presence of not more than 6 carbon atoms, or their acid addition or quaternary ammonium salts. Specification 901,312 is referred to.
GB2554159A 1958-11-04 1959-07-24 Pyridylamino lower alkane derivatives and processes for preparing them Expired GB901311A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US77173658A 1958-11-04 1958-11-04

Publications (1)

Publication Number Publication Date
GB901311A true GB901311A (en) 1962-07-18

Family

ID=25092809

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2554159A Expired GB901311A (en) 1958-11-04 1959-07-24 Pyridylamino lower alkane derivatives and processes for preparing them

Country Status (6)

Country Link
BE (1) BE580121A (en)
CH (1) CH388958A (en)
DE (1) DE1695559C3 (en)
DK (1) DK114899B (en)
GB (1) GB901311A (en)
SE (1) SE306929B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010057922A1 (en) * 2008-11-24 2010-05-27 Basf Se Curable composition comprising a thermolatent base

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5583147A (en) * 1994-03-23 1996-12-10 The Dupont Merck Pharmaceutical Company Amides for the treatment of atherosclerosis

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010057922A1 (en) * 2008-11-24 2010-05-27 Basf Se Curable composition comprising a thermolatent base
US8969577B2 (en) 2008-11-24 2015-03-03 Basf Se Curable composition comprising a thermolatent base

Also Published As

Publication number Publication date
DE1695559B2 (en) 1974-01-03
DE1695559A1 (en) 1972-03-02
DE1695559C3 (en) 1974-07-25
SE306929B (en) 1968-12-16
DE1420056A1 (en) 1968-10-03
CH388958A (en) 1965-03-15
BE580121A (en) 1959-10-16
DK114899B (en) 1969-08-18

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