GB898101A - Amino acid derivatives - Google Patents

Amino acid derivatives

Info

Publication number
GB898101A
GB898101A GB3879559A GB3879559A GB898101A GB 898101 A GB898101 A GB 898101A GB 3879559 A GB3879559 A GB 3879559A GB 3879559 A GB3879559 A GB 3879559A GB 898101 A GB898101 A GB 898101A
Authority
GB
United Kingdom
Prior art keywords
amino
dichloroacetyl
esters
reacting
acids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3879559A
Inventor
Irving Levi
Harold Blondal
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Frosst Canada and Co
Original Assignee
Charles E Frosst and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Charles E Frosst and Co filed Critical Charles E Frosst and Co
Priority to GB3879559A priority Critical patent/GB898101A/en
Publication of GB898101A publication Critical patent/GB898101A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The invention comprises N-dichloroacetyl-a -amino-acid esters of the general formula <FORM:0898101/IV (b)/1> wherein R1 represents hydrogen, methyl, hydroxymethyl, 1-hydroxyethyl, butyl or benzyl and R2 an alkyl group of 1-4 carbon atoms or an aralkyl group. They may be made by reacting the appropriate amino-acid esters with dichloracetyl chloride in the presence of an organic base and in an appropriate solvent, or, for the methyl esters, by reacting the free N-dichloroacetyl-a -amino-acids with diazomethane. The products have anti-tumor activity. The Provisional Specification comprises generally N-dichloroacetyl derivatives of a -amino-acids and their alkali metal salts and alkyl esters.
GB3879559A 1959-11-16 1959-11-16 Amino acid derivatives Expired GB898101A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB3879559A GB898101A (en) 1959-11-16 1959-11-16 Amino acid derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB3879559A GB898101A (en) 1959-11-16 1959-11-16 Amino acid derivatives

Publications (1)

Publication Number Publication Date
GB898101A true GB898101A (en) 1962-06-06

Family

ID=10405737

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3879559A Expired GB898101A (en) 1959-11-16 1959-11-16 Amino acid derivatives

Country Status (1)

Country Link
GB (1) GB898101A (en)

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