GB892742A - New steroid esters and pharmaceutical preparations containing them - Google Patents
New steroid esters and pharmaceutical preparations containing themInfo
- Publication number
- GB892742A GB892742A GB21928/58A GB2192858A GB892742A GB 892742 A GB892742 A GB 892742A GB 21928/58 A GB21928/58 A GB 21928/58A GB 2192858 A GB2192858 A GB 2192858A GB 892742 A GB892742 A GB 892742A
- Authority
- GB
- United Kingdom
- Prior art keywords
- diol
- allopregnane
- fluoro
- ampoules
- esters
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
Abstract
The invention comprises esters of pregnane-and allopregnane-3b ,16a -diol-20-ones, but excludes the 3-monoacetates, the 3,16-diacetates and the 3-acetates-16-benzoates. They may be prepared by conventional esterification and partial hydrolysis techniques. Examples are given, and an extensive list of ester-forming acids is provided, these including organic mono- and dicarboxylic acids, sulphonic acids and inorganic acids, such as phosphoric or sulphuric acids. Particularly preferred are esters whose acyl radical contains a water-solubilizing group, and salts thereof. Allopregnane-3b ,16a -diol-20-one is extracted from ox or pig suprarenal glands, together with corticosterone, 17-hydroxy-cortexone and 11-dehydro-corticosterone. Pregnane-3b ,16a -diol-20-one is prepared by degrading sarsapogenin acetate to D 16-pregnen-3b -ol-20-one acetate, epoxylating and hydrolysing this to 16a ,17a -epoxy-pregnen-3b -ol-20-one and reacting this with chromium acetate in acetic acid. Methoxy - polyethyleneglycol - hemi - D 4 - tetra - hydrophthalate is prepared from polyethylene-glycol monomethyl ether of average molecular weight 350 and D 4-tetrahydrophthalic anhydride, and is converted to the acid chloride by reaction with thionyl chloride.ALSO:Pharmaceutical compositions comprise esters of pregnane- and allopregnane-3b , 16a -diol-20-ones (excluding the 3-monoacetates, the 3,16-diacetates and the 3-acetates-16-benzoates) and carriers therefor. Solutions, suspensions, emulsions, tablets, ampoules, dragees, salves and creams are referred to. The compositions may additionally contain preservatives, stabilizers, wetting agents or emulsifizers, salts for varying the osmotic pressure or buffers. In examples, allopregnane - 3b ,16a - diol - 20 - one 3,16-dipropionate, 3 - trimethylacetate - 16 - acetate and 3,16-di-hemi-succinate and its di-sodium salt are the active ingredients in oil ampoules, crystal ampoules, tablets and ampoules respectively. The tablets may also contain cortisone, prednisone, prednisolone, 9a -fluoro-prednisone, 9a -fluoro-prednisolone, 9a -fluoro-16a - hydroxy-prednisone or 9a -fluoro-16a -hydroxy-prednisolone or esters thereof.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH892742X | 1957-07-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB892742A true GB892742A (en) | 1962-03-28 |
Family
ID=4545944
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB21928/58A Expired GB892742A (en) | 1957-07-08 | 1958-07-08 | New steroid esters and pharmaceutical preparations containing them |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB892742A (en) |
-
1958
- 1958-07-08 GB GB21928/58A patent/GB892742A/en not_active Expired
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