GB965936A - New pregnadienes - Google Patents

New pregnadienes

Info

Publication number
GB965936A
GB965936A GB4551061A GB4551061A GB965936A GB 965936 A GB965936 A GB 965936A GB 4551061 A GB4551061 A GB 4551061A GB 4551061 A GB4551061 A GB 4551061A GB 965936 A GB965936 A GB 965936A
Authority
GB
United Kingdom
Prior art keywords
esters
pregnadienes
new
pregnenes
pregnadiene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4551061A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF Schweiz AG
Original Assignee
Ciba AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba AG filed Critical Ciba AG
Publication of GB965936A publication Critical patent/GB965936A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Abstract

The invention comprises D 1,4-3,20-dioxo-6a -fluoro-16a -methyl-11b , 14a , 17a , 21-tetrahydroxy pregnadiene and 21-esters thereof. They may be prepared by dehydrogenation of the corresponding D 4-pregnenes with, for example, enzymes such as those of the mould Corynebacterium simplex, or chemically with, for example, selenium dioxide. Esters and the free 21-ol may be interconverted by standard esterification and hydrolysis procedures. Examples are given and an extensive list of esterifying organic and inorganic acids is provided. The steroids of the invention, which are stated to have anti-inflammatory properties, may be formulated as pharmaceutical compositions with suitable carriers. These may take the form of solutions, suspensions, emulsions, depot preparations, tablets, dragees, salves or creams and may contain preserving, stabilizing, wetting or emulsifying agents, salts for varying the osmotic pressure or buffers. Specification 965,935 is referred to.
GB4551061A 1960-12-19 1961-12-19 New pregnadienes Expired GB965936A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1416760A CH396898A (en) 1960-12-19 1960-12-19 Process for making new pregnadienes

Publications (1)

Publication Number Publication Date
GB965936A true GB965936A (en) 1964-08-06

Family

ID=4398535

Family Applications (1)

Application Number Title Priority Date Filing Date
GB4551061A Expired GB965936A (en) 1960-12-19 1961-12-19 New pregnadienes

Country Status (2)

Country Link
CH (1) CH396898A (en)
GB (1) GB965936A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3488421A (en) * 1966-07-15 1970-01-06 Angeli Inst Spa Terpenic esters of glucocorticoids

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3488421A (en) * 1966-07-15 1970-01-06 Angeli Inst Spa Terpenic esters of glucocorticoids

Also Published As

Publication number Publication date
CH396898A (en) 1965-08-15

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