GB889228A - Omega-carboxyalkylpenicillins - Google Patents

Omega-carboxyalkylpenicillins

Info

Publication number
GB889228A
GB889228A GB11004/60A GB1100460A GB889228A GB 889228 A GB889228 A GB 889228A GB 11004/60 A GB11004/60 A GB 11004/60A GB 1100460 A GB1100460 A GB 1100460A GB 889228 A GB889228 A GB 889228A
Authority
GB
United Kingdom
Prior art keywords
penicillin
penicillins
formula
carboxyalkylpenicillins
omega
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB11004/60A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GIORGIO MORPURGO
Fondazione Emanuele Paterno
Original Assignee
GIORGIO MORPURGO
Fondazione Emanuele Paterno
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GIORGIO MORPURGO, Fondazione Emanuele Paterno filed Critical GIORGIO MORPURGO
Publication of GB889228A publication Critical patent/GB889228A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/44—Compounds with an amino radical acylated by carboxylic acids, attached in position 6
    • C07D499/48—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Penicillins of the formula <FORM:0889228/IV (b)/1> where n is an integer from 0 to 15, such as 4-carboxybutyl, 5-carboxyamyl, and 6-carboxyhexyl penicillin, are prepared by fermenting in an aqueous nutrient medium under submerged aerobic conditions a strain of Penicillin chrysogenum in the presence of a percursor of the formula HO2C-(CH2)n-CO2H in a ratio of 0.1 to 1.0 g./100 ml. until substantial antibiotic activity is imparted to the reaction medium. The penicillins, which are hydrophilic, are obtained from the culture media by first extracting other penicillin at acid pH with organic solvents, and then fixing the desired penicillin on suitable adsorbing material, such as charcoal or alumina, from where it is eluted with acetone or other water-miscible organic solvent.
GB11004/60A 1959-03-31 1960-03-29 Omega-carboxyalkylpenicillins Expired GB889228A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT889228X 1959-03-31

Publications (1)

Publication Number Publication Date
GB889228A true GB889228A (en) 1962-02-14

Family

ID=11331316

Family Applications (1)

Application Number Title Priority Date Filing Date
GB11004/60A Expired GB889228A (en) 1959-03-31 1960-03-29 Omega-carboxyalkylpenicillins

Country Status (1)

Country Link
GB (1) GB889228A (en)

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