GB888525A - New aryloxy-aliphatic hydrazines - Google Patents

Abstract

The invention comprises monoaliphatically substituted hydrazines the aliphatic radical of which is substituted by an aryloxy radical and acyl derivatives of these hydrazines with the exception of 2-phenoxyethylhydrazine and physiologically tolerable acid addition salts of these compounds. The aryl residue may be substituted by a halogen atom, a hydroxyl group substituted by a C1-6 aliphatic or cycloaliphatic hydrocarbon radical or by a C1-6 alkyl radical. The aliphatic radical may be substituted by free hydroxyl groups. The compounds are prepared by treating an aryloxyaliphatic compound whose aliphatic residue contains a radical replaceable by or convertable into a hydrazine group which may be acylated so as to replace or convert the said radical into a hydrazine group. A radical replaceable by a hydrazino group is especially an epoxy group or a reactive esterified hydroxyl group and a radical convertable into a hydrazino group is a hydrazone group. The hydrazines may be acylated or acyl desivatives hydrolysed. 1-Phenoxypropyl-(2)-chloride is prepared by reducing phenoxyacetone to 1-phenoxypropanol-(2) with sodium borohydride and reacting the alkanol with thionyl chloride. N - [1 - Phenoxypropylidene - (2)] - N1 - acetylhydrazine is prepared from phenoxyacetone and acetylhydrazine.ALSO:Pharmaceutical compositions comprise monoaliphatically substituted hydrazines, the aliphatic radical of which is substituted by an aryloxy radical, and acyl derivatives of these hydrazines with the exception of 2-phenoxyethyl hydrazine and physiologically tolerable acid. Addition salts of these compounds with organic and inorganic acids in admixture or in conjunction with a pharmaceutical carrier suitable for enteral or parenteral administration. The compositions which may contain further therapeutically valuable substances may be in the form of tablets, dragees, suspensions or emulsions.