GB880548A - Dihydro-benzo-thia-diazepine-dioxide and derivatives thereof - Google Patents

Dihydro-benzo-thia-diazepine-dioxide and derivatives thereof

Info

Publication number
GB880548A
GB880548A GB3901758A GB3901758A GB880548A GB 880548 A GB880548 A GB 880548A GB 3901758 A GB3901758 A GB 3901758A GB 3901758 A GB3901758 A GB 3901758A GB 880548 A GB880548 A GB 880548A
Authority
GB
United Kingdom
Prior art keywords
dihydro
dioxide
aminobenzylsulphonamide
benzothiadiazepine
reaction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3901758A
Inventor
Uberto Teotino
Giorgio Cignarella
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gruppo Lepetit SpA
Original Assignee
Lepetit SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lepetit SpA filed Critical Lepetit SpA
Priority to GB3901758A priority Critical patent/GB880548A/en
Priority to CH8061059A priority patent/CH374079A/en
Publication of GB880548A publication Critical patent/GB880548A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/36—Seven-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)

Abstract

The invention comprises 1,3-dihydro-2,3,5-benzothiadiazepine-2,2-dioxides of the formula <FORM:0880548/IV (b)/1> wherein X is hydrogen or a halogen (e.g. 1,3-dihydro - 2, 3, 5 - benzothiadiazepine - 2; 2 - dioxide and its 8-bromo-derivative) and their preparation by heating a 2-aminobenzylsulphonamide with ethyl orthoformate at 100 DEG C to 130 DEG C, in an inert organic solvent boiling at a higher temperature than that of the reaction, while continuously distilling off the ethanol evolved. 2-Aminobenzylsulphonamide and its halo derivatives used as starting materials are made by treating a 2-nitrobenzyl sulphonyl chloride (obtained by reaction of 2-nitrobenzyl chloride with thiourea and chlorination of the resulting addition product) with ammonia in an inert anhydrous organic solvent and reducing the resulting 2-nitrobenzylsulphonamide by hydrogenation at room temperature and atmospheric pressure, in the presence of a palladium on charcoal catalyst.
GB3901758A 1958-12-03 1958-12-03 Dihydro-benzo-thia-diazepine-dioxide and derivatives thereof Expired GB880548A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
GB3901758A GB880548A (en) 1958-12-03 1958-12-03 Dihydro-benzo-thia-diazepine-dioxide and derivatives thereof
CH8061059A CH374079A (en) 1958-12-03 1959-11-13 Process for the preparation of new heterocyclic compounds

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB3901758A GB880548A (en) 1958-12-03 1958-12-03 Dihydro-benzo-thia-diazepine-dioxide and derivatives thereof

Publications (1)

Publication Number Publication Date
GB880548A true GB880548A (en) 1961-10-25

Family

ID=10407091

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3901758A Expired GB880548A (en) 1958-12-03 1958-12-03 Dihydro-benzo-thia-diazepine-dioxide and derivatives thereof

Country Status (2)

Country Link
CH (1) CH374079A (en)
GB (1) GB880548A (en)

Also Published As

Publication number Publication date
CH374079A (en) 1963-12-31

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