GB878068A - Improvements in or relating to the preparation of basic benzilic acid ester derivatives - Google Patents
Improvements in or relating to the preparation of basic benzilic acid ester derivativesInfo
- Publication number
- GB878068A GB878068A GB33191/59A GB3319159A GB878068A GB 878068 A GB878068 A GB 878068A GB 33191/59 A GB33191/59 A GB 33191/59A GB 3319159 A GB3319159 A GB 3319159A GB 878068 A GB878068 A GB 878068A
- Authority
- GB
- United Kingdom
- Prior art keywords
- acid ester
- benzilic acid
- benzilic
- basic
- diphenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The invention comprises a basic benzilic acid ester derivative of general formula <FORM:0878068/IV (b)/1> in which R is a halogen or hydroxyl group, which may be free, esterified or etherified, or an acid-addition or quaternary ammonium salt of a compound of the above general formula such as the hydrochloride, hydrobromide and methiodide, and processes for the preparation of such a compound (1) by esterifying benzilic acid or a functional derivative (such as the ethyl ester) with 1-dimethylaminopropan-2-ol or with 1-dimethylamino-2-halopropane, (2) by reacting an a ,a -diphenyl-a -acyloxyacetyl halide with 1-dimethylaminopropan-2-ol, (3) by replacing the free hydroxyl group of the benzilic acid ester by a halogen atom by means of thionyl halide, (4) by esterifying the free hydroxyl group of the benzilic acid ester by means of an acid anhydride or chloride, (5) by replacing the halogen atom of the required a ,a -diphenyl-a -haloacetic acid ester by an alkyloxy group, for example by heating with an alcohol or alkali metal alcoholate, and (6) by reacting a ,a -diphenyl-a -alkoxyacetic acid ester with 1-dimethylamino-propanol-(2) and continuously distilling off the alcohol formed. In each of the above processes, the resulting basic benzilic acid ester may be converted into an acid addition or quaternary salt. Detailed examples are given.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB33191/59A GB878068A (en) | 1959-09-30 | 1959-09-30 | Improvements in or relating to the preparation of basic benzilic acid ester derivatives |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB33191/59A GB878068A (en) | 1959-09-30 | 1959-09-30 | Improvements in or relating to the preparation of basic benzilic acid ester derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB878068A true GB878068A (en) | 1961-09-27 |
Family
ID=10349757
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB33191/59A Expired GB878068A (en) | 1959-09-30 | 1959-09-30 | Improvements in or relating to the preparation of basic benzilic acid ester derivatives |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB878068A (en) |
-
1959
- 1959-09-30 GB GB33191/59A patent/GB878068A/en not_active Expired
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US2513346A (en) | Process for obtaining organic amino diols | |
| GB878068A (en) | Improvements in or relating to the preparation of basic benzilic acid ester derivatives | |
| GB831920A (en) | New phenthiazine derivatives and processes for their preparation | |
| DK260881A (en) | BIS AND MONO QUATERNARY AMMONIUM DERIVATIVES OF 2BETA, 16BETA-DIPERIDINO-5ALFA ANDROSTANES PROCEDURE FOR PREPARING THEREOF AND PHARMACEUTICAL PREPARATIONS CONTAINING ANDROSTANE COMPOUNDS | |
| GB888535A (en) | Indole compounds | |
| GB813218A (en) | Nor-tropines and nor-pseudo-tropines and process for their production | |
| GB886437A (en) | Improvements in or relating to basic esters of etherified benzilic acids | |
| GB803440A (en) | Improvements in or relating to estradiol derivatives | |
| GB930676A (en) | Process for the preparation of 20-alkylamino steroid derivatives and novel 20-alkylamino steroid derivatives prepared thereby | |
| GB920841A (en) | Diphenyl-methane derivatives and process for their manufacture | |
| GB855022A (en) | Improvements in and relating to carbostyril derivatives | |
| US2763654A (en) | Methyl reserpate o-acetoacetate | |
| GB911600A (en) | Derivatvies of 17-epi-oestriol and process for the preparation thereof | |
| GB1107036A (en) | Esters of dibenzocycloheptenyl-carboxylic acids | |
| GB773756A (en) | 9-aminoalkyl-9-xanthenecarboxamides and derivatives thereof | |
| GB1024650A (en) | Benzofuran derivatives and process for their production | |
| GB1018780A (en) | Steroid (2,3í¬c) furazan compounds and the process for the production thereof | |
| GB882894A (en) | Phenothiazine-derivatives | |
| GB837841A (en) | Reserpic acid diesters and salts thereof and process for their manufacture | |
| GB1094273A (en) | Adipimide derivatives | |
| GB774463A (en) | Alkaloid derivatives and process for their manufacture | |
| GB837949A (en) | Reserpic acid diesters and salts thereof and process for their manufacture | |
| GB976728A (en) | Novel steroid compounds and their preparation | |
| GB873236A (en) | Succinic esters | |
| GB1110090A (en) | Cyano steroid derivatives |