GB864609A - Improvements in or relating to the preparation of 4-chloro-3-keto-í¸-steroids - Google Patents
Improvements in or relating to the preparation of 4-chloro-3-keto-í¸-steroidsInfo
- Publication number
- GB864609A GB864609A GB15920/57A GB1592057A GB864609A GB 864609 A GB864609 A GB 864609A GB 15920/57 A GB15920/57 A GB 15920/57A GB 1592057 A GB1592057 A GB 1592057A GB 864609 A GB864609 A GB 864609A
- Authority
- GB
- United Kingdom
- Prior art keywords
- chloro
- testosterone
- chlorine
- keto
- steroids
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Abstract
The invention comprises 4-chloro-testosterone cyclopentylpropionate and a process for the preparation of 4-chloro-3-keto-D 4-steroids by reacting 3-keto-D 4-steroids with chlorine in an organic solvent which is inert to chlorine such as carbon tetrachloride, preferably in the presence of a tertiary organic base such as pyridine. The chlorine may be provided by a substance which releases chlorine under the reaction conditions, e.g. by means of acetic acid as the reaction solvent and t-butyl-hypochlorite. The preferred reactants for the above process have the general formula: <FORM:0864609/IV (b)/1> wherein R represents =(H)OR111, =O, =(CH3)OH, =(C2H5)OH, =(H)COCH3, =(H)OCOCH3, =(H)COCH2OCOCH3, or =(OH)COCH2OCOCH3, R1 represents =(H)H, =(H)OH or =O, R11 represents -H or -CH3 and R111 represents an acyl group. In the examples 4-chloro-testosterone acetate, 4-chloro-testosterone b -cyclopentylpropionate, 4-chloro-19-nortestosterone acetate, 4-chloroprogesterone, and 4-chloro-desoxycorticosterone acetate are prepared. Specifications 838,773, 864,608 and 864,613 are referred to. Reference has been directed by the Comptroller to Specification 792,727.ALSO:A pharmaceutical composition contains 4-chloro-testosterone cyclopentylpropionate and a compatible solid or liquid carrier therefor. Reference has been directed by the Comptroller to Specification 792,727.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT864609X | 1956-05-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB864609A true GB864609A (en) | 1961-04-06 |
Family
ID=11330580
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB15920/57A Expired GB864609A (en) | 1956-05-25 | 1957-05-20 | Improvements in or relating to the preparation of 4-chloro-3-keto-í¸-steroids |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB864609A (en) |
-
1957
- 1957-05-20 GB GB15920/57A patent/GB864609A/en not_active Expired
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