GB853322A - Carbamic acid esters - Google Patents
Carbamic acid estersInfo
- Publication number
- GB853322A GB853322A GB13285/58A GB1328558A GB853322A GB 853322 A GB853322 A GB 853322A GB 13285/58 A GB13285/58 A GB 13285/58A GB 1328558 A GB1328558 A GB 1328558A GB 853322 A GB853322 A GB 853322A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- carbamyl
- hydrogen
- reacting
- prepared
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
Abstract
The invention comprises mono-or dicarbamates of a 2:2-dichloro-1-aryl-1:3-propane diol of the formula : <FORM:0853322/IV(b)/1> wherein one R is carbamyl and the other R is hydrogen or carbamyl, R1 is hydrogen, C1-7 alkyl, C1-7 alkoxy, halogen or trifluoromethyl and n is 1 or 2. The compounds are prepared by reacting a cyclic carbonic ester of the formula : <FORM:0853322/IV(b)/2> or the corresponding 1:3-chlorocarbonate, with ammonia, preferably liquid ammonia in the cold. Cyclic carbonic esters of the formula : <FORM:0853322/IV(b)/3> are prepared by reacting a diol of the formula : <FORM:0853322/IV(b)/4> with an equimolor amount of phosgene. Diols of the above formula are prepared by reacting an ester of a compound of the formula : <FORM:0853322/IV(b)/5> with a chlorinating agent (e.g. sulphuryl chloride) to form the corresponding a :a -dichloroacetic acid ester, and treating the latter compound with a hydrogenating agent (e.g. lithium aluminium hydride).ALSO:A pharmaceutical composition comprises as the active ingredient a mono or dicarbonate of a 2:2-dichloro-1-aryl-1:3-propane diol of the formula: <FORM:0853322/VI/1> wherein one R is carbamyl and the other is hydrogen or carbamyl, R1 is hydrogen, C1-7 alkyl, C1-7 alkoxy, halogen or trifluoromethyl, and n is 1 or 2. The composition may be formulated in tablets, capsules or elixirs.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US853322XA | 1957-04-25 | 1957-04-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB853322A true GB853322A (en) | 1960-11-02 |
Family
ID=22190892
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB13285/58A Expired GB853322A (en) | 1957-04-25 | 1958-04-25 | Carbamic acid esters |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB853322A (en) |
-
1958
- 1958-04-25 GB GB13285/58A patent/GB853322A/en not_active Expired
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