GB853232A - Improvements in or relating to coenzyme a - Google Patents
Improvements in or relating to coenzyme aInfo
- Publication number
- GB853232A GB853232A GB28079/57A GB2807957A GB853232A GB 853232 A GB853232 A GB 853232A GB 28079/57 A GB28079/57 A GB 28079/57A GB 2807957 A GB2807957 A GB 2807957A GB 853232 A GB853232 A GB 853232A
- Authority
- GB
- United Kingdom
- Prior art keywords
- metal salt
- coenzyme
- aqueous solution
- reaction
- calcium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
A stable metal salt reaction product of coenzyme A is obtained by reacting coenzyme A with a water-soluble non-deliquescent metal salt in aqueous solution and then lyophilizing the reaction mixture. The metal salt is suitably a metal salt of a divalent acid and may be a salt of an organic acid or of a mineral acid such as hydrochloric acid. It is preferably a divalent metal salt of a dibasic organic acid. Specified salts are the salts of calcium, copper (cupric), magnesium, cadmium, nickel (nickelous), cobalt (cobaltous), iron (ferrous) and manganese with gluconic, benzoic, citric, acetic, formic, lactic, succinic, tartaric, hydrochloric, sulphuric, and nitric acids in so far as such salts are watersoluble and non-deliquescent. The reaction is preferably carried out by mixing the two reactants in aqueous solution at room temperature and then lyophilizing the solution thus obtained. The product after lyophilization is enzymatically stable and has the same spectrophotometric and chromatographic characteristics as pure coenzyme A stabilized by cold. In aqueous solution the product decomposes by hydrolysis to give coenzyme A. A stoichiometric excess of the metal salt may be used in the reaction. Examples are given in which coenzyme A is reacted with calcium gluconate, calcium benzoate, and calcium citrate respectively in aqueous solution. The solution is then filled into ampoules which are placed in a refrigerator and frozen to-70 DEG C. in 15 minutes. The mixture is then evaporated in vacuo over 10 hours with progressive increase of temperature to about 20 DEG C. and the ampoules are finally filled with nitrogen and sealed.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US853232XA | 1956-09-05 | 1956-09-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB853232A true GB853232A (en) | 1960-11-02 |
Family
ID=22190834
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB28079/57A Expired GB853232A (en) | 1956-09-05 | 1957-09-05 | Improvements in or relating to coenzyme a |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB853232A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5712258A (en) * | 1995-03-23 | 1998-01-27 | The Trustees Of The University Of Pennsylvania | Inotropic ADP and ATP analogues and their pharmaceutical compositions |
| US7348315B2 (en) | 1995-03-23 | 2008-03-25 | The University Of Connecticut | Methods of treating heart failure with modified ATP, ADP and AMP compounds |
-
1957
- 1957-09-05 GB GB28079/57A patent/GB853232A/en not_active Expired
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5712258A (en) * | 1995-03-23 | 1998-01-27 | The Trustees Of The University Of Pennsylvania | Inotropic ADP and ATP analogues and their pharmaceutical compositions |
| US6255292B1 (en) | 1995-03-23 | 2001-07-03 | The Trustees Of The University Of Pennsylvania | Purine nucleotide analogues, pharmaceutical compositions thereof, and methods of improving cardiac functions |
| US7348315B2 (en) | 1995-03-23 | 2008-03-25 | The University Of Connecticut | Methods of treating heart failure with modified ATP, ADP and AMP compounds |
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