GB841231A - Process for the manufacture of 4-sulphanilamido-2, 6-dimethoxy-pyrimidine - Google Patents
Process for the manufacture of 4-sulphanilamido-2, 6-dimethoxy-pyrimidineInfo
- Publication number
- GB841231A GB841231A GB908658A GB908658A GB841231A GB 841231 A GB841231 A GB 841231A GB 908658 A GB908658 A GB 908658A GB 908658 A GB908658 A GB 908658A GB 841231 A GB841231 A GB 841231A
- Authority
- GB
- United Kingdom
- Prior art keywords
- amino
- pyrimidine
- dimethoxy
- sulphanilamido
- substituent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- ZZORFUFYDOWNEF-UHFFFAOYSA-N sulfadimethoxine Chemical compound COC1=NC(OC)=CC(NS(=O)(=O)C=2C=CC(N)=CC=2)=N1 ZZORFUFYDOWNEF-UHFFFAOYSA-N 0.000 title 1
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 6
- -1 alkali-metal methoxide Chemical class 0.000 abstract 4
- XHXFXVLFKHQFAL-UHFFFAOYSA-N phosphoryl trichloride Chemical compound ClP(Cl)(Cl)=O XHXFXVLFKHQFAL-UHFFFAOYSA-N 0.000 abstract 4
- PAYRUJLWNCNPSJ-UHFFFAOYSA-N Aniline Chemical compound NC1=CC=CC=C1 PAYRUJLWNCNPSJ-UHFFFAOYSA-N 0.000 abstract 2
- 238000010438 heat treatment Methods 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- DNCYBUMDUBHIJZ-UHFFFAOYSA-N 1h-pyrimidin-6-one Chemical compound O=C1C=CN=CN1 DNCYBUMDUBHIJZ-UHFFFAOYSA-N 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 238000009835 boiling Methods 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000006627 ethoxycarbonylamino group Chemical group 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 238000005292 vacuum distillation Methods 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/69—Benzenesulfonamido-pyrimidines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT197057 | 1957-03-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB841231A true GB841231A (en) | 1960-07-13 |
Family
ID=3524986
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3237059A Expired GB841239A (en) | 1957-03-26 | 1958-03-21 | Process for the manufacture of 4-amino-2, 6-dichloro-pyrimidine |
| GB908658A Expired GB841231A (en) | 1957-03-26 | 1958-03-21 | Process for the manufacture of 4-sulphanilamido-2, 6-dimethoxy-pyrimidine |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3237059A Expired GB841239A (en) | 1957-03-26 | 1958-03-21 | Process for the manufacture of 4-amino-2, 6-dichloro-pyrimidine |
Country Status (7)
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB866842A (en) * | 1958-12-08 | 1961-05-03 | Ici Ltd | Pyrimidines |
| DE1276040B (de) * | 1959-11-18 | 1968-08-29 | Hoffmann La Roche | Verfahren zur Herstellung von 2, 6-Dimethoxy-4-sulfanilamidopyrimidin |
| CN105646373B (zh) * | 2016-02-18 | 2018-05-29 | 滨海新东方医化有限公司 | 一种4-氨基-2,6-二甲氧基嘧啶的制备方法 |
-
0
- NL NL100261D patent/NL100261C/xx active
- NL NL100350D patent/NL100350C/xx active
- BE BE565823D patent/BE565823A/xx unknown
-
1958
- 1958-03-10 CH CH5683558A patent/CH369454A/de unknown
- 1958-03-12 DE DEH32653A patent/DE1098516B/de active Pending
- 1958-03-21 GB GB3237059A patent/GB841239A/en not_active Expired
- 1958-03-21 FR FR1203619D patent/FR1203619A/fr not_active Expired
- 1958-03-21 GB GB908658A patent/GB841231A/en not_active Expired
-
1962
- 1962-12-31 MY MY6200012A patent/MY6200012A/xx unknown
- 1962-12-31 MY MY6200011A patent/MY6200011A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NL100350C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | |
| MY6200011A (en) | 1962-12-31 |
| GB841239A (en) | 1960-07-13 |
| FR1203619A (fr) | 1960-01-20 |
| DE1098516B (de) | 1961-02-02 |
| MY6200012A (en) | 1962-12-31 |
| NL100261C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | |
| BE565823A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | |
| CH369454A (de) | 1963-05-31 |
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