GB835725A - Purification of phenoxymethyl penicillin - Google Patents
Purification of phenoxymethyl penicillinInfo
- Publication number
- GB835725A GB835725A GB3577757A GB3577757A GB835725A GB 835725 A GB835725 A GB 835725A GB 3577757 A GB3577757 A GB 3577757A GB 3577757 A GB3577757 A GB 3577757A GB 835725 A GB835725 A GB 835725A
- Authority
- GB
- United Kingdom
- Prior art keywords
- penicillin
- extract
- organic solvent
- water
- aqueous
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D499/44—Compounds with an amino radical acylated by carboxylic acids, attached in position 6
- C07D499/48—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical
- C07D499/58—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical
- C07D499/60—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical by oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Phenoxymethyl penicillin is recovered from crude fermentation broths containing it by extracting the penicillin from the broth at a pH value below 3.5 and preferably pH 2.0 to 2.3 into a substantially water-immiscible organic solvent, treating the solution so obtained with active carbon, re-extracting the phenoxymethyl penicillin into an aqueous solution at a pH value between 6 and 8.5, and precipitating phenoxymethyl penicillin from the aqueous extract in the presence of a minor proportion of a water-miscible organic solvent by acidifying the extract. Suitable water-immiscible organic solvents are alkyl esters of organic acids such as butyl acetate and alkanols such as n-butanol. The broth is preferably clarified prior to the organic solvent extraction. The extract is treated with 0.2 to 1.0% w./v. carbon. After filtering off the carbon, the organic extract is treated with an aqueous phosphate or sodium bicarbonate or potassium bicarbonate buffer solution so that the final aqueous extract contains 10,000 to 100,000 m g./ml. of penicillin V. The water-miscible organic solvent is a ketone such as acetone or an alkanol such as ethanol or isopropanol and is used in quantities of 5 to 15%. Reference has been directed by the Comptroller to Specification 734,232.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3577757A GB835725A (en) | 1957-11-18 | 1957-11-18 | Purification of phenoxymethyl penicillin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3577757A GB835725A (en) | 1957-11-18 | 1957-11-18 | Purification of phenoxymethyl penicillin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB835725A true GB835725A (en) | 1960-05-25 |
Family
ID=10381447
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3577757A Expired GB835725A (en) | 1957-11-18 | 1957-11-18 | Purification of phenoxymethyl penicillin |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB835725A (en) |
-
1957
- 1957-11-18 GB GB3577757A patent/GB835725A/en not_active Expired
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