GB834579A - Hydrohalide salts of oxytetracycline - Google Patents
Hydrohalide salts of oxytetracyclineInfo
- Publication number
- GB834579A GB834579A GB23427/56A GB2342756A GB834579A GB 834579 A GB834579 A GB 834579A GB 23427/56 A GB23427/56 A GB 23427/56A GB 2342756 A GB2342756 A GB 2342756A GB 834579 A GB834579 A GB 834579A
- Authority
- GB
- United Kingdom
- Prior art keywords
- oxytetracycline
- methanol
- chloride
- halide
- metal halide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
Abstract
An hydrohalide salt of oxytetracycline is obtained by dissolving up to about 0.3 g./ml. amphoteric oxytetracycline in an aliphatic alcohol of up to six carbon atoms in the presence of a solubilizing agent consisting of (a) 0.01 to 0.05 g./ml. of a hydrogen halide, (b) 0.02 to 0.3 g./ml. of a soluble alkali metal halide, (c) 0.02 to 0.3 g./ml. of a soluble alkaline earth metal halide other than calcium chloride, or (d) 0.02 to 0.3 g./ml. of a soluble zinc halide, and subsequently treating said solution with 0.02 to 0.06 g./ml. of a hydrogen halide thereby precipitating said oxytetracycline hydrohalide salt. The metal halide should be soluble in the particular solvent selected to the extent of at least 0.02 g./ml. at ordinary temperatures. Useful combinations are calcium bromide in methanol or ethanol, strontium chloride in methanol, magnesium chloride in methanol, sodium bromide in methanol, zinc chloride in methanol and lithium chloride in methanol. Suitable hydrogen halides are anhydrous hydrogen chloride, concentrated hydrochloric acid and concentrated hydrobromic acid. Amphoteric oxytetracycline may be produced in situ by treating a suspension of crude oxytetracycline hydrohalide with an organic amino in the aliphatic alcohol. The suspension of oxytetracycline so produced is then treated with an alcohol solution of the metal halide, filtered and the hydrohalide salt precipitated by the addition of the appropriate acid. Suitable amines are pyridine, piperidine, triethylamine, trimethylamine and ethanolamine. Specification 684,417 is referred to.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US834579XA | 1955-09-19 | 1955-09-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB834579A true GB834579A (en) | 1960-05-11 |
Family
ID=22178470
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB23427/56A Expired GB834579A (en) | 1955-09-19 | 1956-07-30 | Hydrohalide salts of oxytetracycline |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB834579A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993020042A1 (en) * | 1992-04-06 | 1993-10-14 | Pliva Handels Gmbh | Process and intermediate for the purification of oxytetracycline |
-
1956
- 1956-07-30 GB GB23427/56A patent/GB834579A/en not_active Expired
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993020042A1 (en) * | 1992-04-06 | 1993-10-14 | Pliva Handels Gmbh | Process and intermediate for the purification of oxytetracycline |
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