GB834579A - Hydrohalide salts of oxytetracycline - Google Patents

Hydrohalide salts of oxytetracycline

Info

Publication number
GB834579A
GB834579A GB23427/56A GB2342756A GB834579A GB 834579 A GB834579 A GB 834579A GB 23427/56 A GB23427/56 A GB 23427/56A GB 2342756 A GB2342756 A GB 2342756A GB 834579 A GB834579 A GB 834579A
Authority
GB
United Kingdom
Prior art keywords
oxytetracycline
methanol
chloride
halide
metal halide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB23427/56A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Charles Pfizer and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc, Charles Pfizer and Co Inc filed Critical Pfizer Inc
Publication of GB834579A publication Critical patent/GB834579A/en
Expired legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/65Tetracyclines

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)

Abstract

An hydrohalide salt of oxytetracycline is obtained by dissolving up to about 0.3 g./ml. amphoteric oxytetracycline in an aliphatic alcohol of up to six carbon atoms in the presence of a solubilizing agent consisting of (a) 0.01 to 0.05 g./ml. of a hydrogen halide, (b) 0.02 to 0.3 g./ml. of a soluble alkali metal halide, (c) 0.02 to 0.3 g./ml. of a soluble alkaline earth metal halide other than calcium chloride, or (d) 0.02 to 0.3 g./ml. of a soluble zinc halide, and subsequently treating said solution with 0.02 to 0.06 g./ml. of a hydrogen halide thereby precipitating said oxytetracycline hydrohalide salt. The metal halide should be soluble in the particular solvent selected to the extent of at least 0.02 g./ml. at ordinary temperatures. Useful combinations are calcium bromide in methanol or ethanol, strontium chloride in methanol, magnesium chloride in methanol, sodium bromide in methanol, zinc chloride in methanol and lithium chloride in methanol. Suitable hydrogen halides are anhydrous hydrogen chloride, concentrated hydrochloric acid and concentrated hydrobromic acid. Amphoteric oxytetracycline may be produced in situ by treating a suspension of crude oxytetracycline hydrohalide with an organic amino in the aliphatic alcohol. The suspension of oxytetracycline so produced is then treated with an alcohol solution of the metal halide, filtered and the hydrohalide salt precipitated by the addition of the appropriate acid. Suitable amines are pyridine, piperidine, triethylamine, trimethylamine and ethanolamine. Specification 684,417 is referred to.
GB23427/56A 1955-09-19 1956-07-30 Hydrohalide salts of oxytetracycline Expired GB834579A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US834579XA 1955-09-19 1955-09-19

Publications (1)

Publication Number Publication Date
GB834579A true GB834579A (en) 1960-05-11

Family

ID=22178470

Family Applications (1)

Application Number Title Priority Date Filing Date
GB23427/56A Expired GB834579A (en) 1955-09-19 1956-07-30 Hydrohalide salts of oxytetracycline

Country Status (1)

Country Link
GB (1) GB834579A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993020042A1 (en) * 1992-04-06 1993-10-14 Pliva Handels Gmbh Process and intermediate for the purification of oxytetracycline

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993020042A1 (en) * 1992-04-06 1993-10-14 Pliva Handels Gmbh Process and intermediate for the purification of oxytetracycline

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