GB814280A - Improvements in or relating to the purification of lysine - Google Patents
Improvements in or relating to the purification of lysineInfo
- Publication number
- GB814280A GB814280A GB6102/58A GB610258A GB814280A GB 814280 A GB814280 A GB 814280A GB 6102/58 A GB6102/58 A GB 6102/58A GB 610258 A GB610258 A GB 610258A GB 814280 A GB814280 A GB 814280A
- Authority
- GB
- United Kingdom
- Prior art keywords
- lysine
- racemized
- mineral acid
- weight
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000004472 Lysine Substances 0.000 title abstract 11
- 238000000746 purification Methods 0.000 title abstract 2
- 239000002253 acid Substances 0.000 abstract 7
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract 6
- 239000011707 mineral Substances 0.000 abstract 6
- KDXKERNSBIXSRK-UHFFFAOYSA-N DL-lysine Chemical compound NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N HCl Chemical class Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 3
- 238000010438 heat treatment Methods 0.000 abstract 3
- 239000000543 intermediate Substances 0.000 abstract 3
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 abstract 2
- 150000007513 acids Chemical class 0.000 abstract 2
- 229940091173 hydantoin Drugs 0.000 abstract 2
- 235000011167 hydrochloric acid Nutrition 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- BOWUOGIPSRVRSJ-UHFFFAOYSA-N 2-aminohexano-6-lactam Chemical compound NC1CCCCNC1=O BOWUOGIPSRVRSJ-UHFFFAOYSA-N 0.000 abstract 1
- 229960002989 Glutamic Acid Drugs 0.000 abstract 1
- WJRBRSLFGCUECM-UHFFFAOYSA-N Hydantoin Chemical compound O=C1CNC(=O)N1 WJRBRSLFGCUECM-UHFFFAOYSA-N 0.000 abstract 1
- 238000005903 acid hydrolysis reaction Methods 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 238000005341 cation exchange Methods 0.000 abstract 1
- 239000012535 impurity Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 235000011007 phosphoric acid Nutrition 0.000 abstract 1
- 239000012429 reaction media Substances 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
- 235000011149 sulphuric acid Nutrition 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/38—Separation; Purification; Stabilisation; Use of additives
- C07C227/40—Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine
Abstract
Lysine which has been racemized and which contains impurities, such as alpha-amino-epsilon-caprolactam, deleteriously affecting its resolution, is purified by heating it with an aqueous solution of a strong mineral acid, thus producing a lysine capable of more ready resolution. The crude racemized lysine may be obtained by heating optically active lysine with a cation-exchange material, as described in U.S.A. Specification 2,536,360. Specified mineral acids are phosphoric, sulphuric and hydrochloric acids and mixtures of two or more such acids. The concentration of the acid may range from 1 to 50 per cent by weight, that of hydrochloric acid being preferably from 1 to 37 per cent by weight. Preferably from 1.2 to 8 mols. of mineral acid are used per mol. of lysine, the concentration of the lysine in the reaction medium being preferably from 0.5 to 70 per cent by weight, based on the weight of the lysine solution, before addition of the mineral acid. The heat treatment may range from 70 DEG to 220 DEG C. for a duration of 1 to 24 hours. The above purification treatment can be carried out in conjunction with the mineral acid hydrolysis of lysine-yielding intermediates, such as poly-3:5-tetramethylene hydantoin and 5-(delta-aminobutyl) hydantoin, to produce DL-lysine. Thus the crude racemized lysine may be mixed with the lysine-yielding intermediate and the mixture heated with the mineral acid to produce resolvable DL-lysine from the intermediate and resolvable DL-lysine from the crude racemized lysine simultaneously. The examples describe the treatment of lysine which has been racemized by the method of U.S.A. Specification 2,536,360 and its subsequent resolution with L-glutamic acid.
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB814280A true GB814280A (en) | 1959-06-03 |
Family
ID=1628511
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB6102/58A Expired GB814280A (en) | 1958-02-25 | Improvements in or relating to the purification of lysine |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB814280A (en) |
-
1958
- 1958-02-25 GB GB6102/58A patent/GB814280A/en not_active Expired
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB814280A (en) | Improvements in or relating to the purification of lysine | |
| DE3478433D1 (en) | Process for the racemisation of optically active aminoacids | |
| ES8100017A1 (en) | Process for the production of overbased manganese salts of organic acids | |
| US3488386A (en) | Process for recovering acetic acid | |
| GB905817A (en) | Improvements in the purification of citric acid | |
| GB943536A (en) | Process for the production of methacrylic acid derivatives | |
| US2846439A (en) | Reaction of threonines with aryl nitriles in a steric inversion process | |
| GB1323478A (en) | Process of preparing polyalkylenglycol dibenzoates | |
| GB747417A (en) | Improvements in or relating to the production of phthalic acids | |
| US2418902A (en) | Process for producing pantothenic acid | |
| ATE69804T1 (en) | PROCESS FOR THE PREPARATION OF D-OR L-ALANINE OF HIGH ENANTIOMER PURITY. | |
| SE7909596L (en) | PROCEDURE FOR PREPARING BASIC ESTERS OF SUBSTITUTED HYDROXICYCLOHEXANCHOXYL ACIDS | |
| SU125553A1 (en) | Method for preparing hydroxyalkyl oxyalkyliminoesters of 6-cyanoalerianic acid | |
| ES483076A1 (en) | Process for the purification of tryptophane and derivatives of tryptophane | |
| US2878282A (en) | Purification of lysine | |
| GB939905A (en) | A process for preparing a penillic acid and salts thereof | |
| GB1174871A (en) | Monoisocyanates and Polyisocyanates | |
| SU145244A1 (en) | The method of obtaining esters of Kamenovo acid | |
| GB1260806A (en) | Optical resolution of d,l-lysine | |
| GB749098A (en) | Improvements in and relating to the purification of acetic anhydride | |
| GB914734A (en) | New cyclopentano-naphthalene derivatives and their formation | |
| GB761820A (en) | Process for the production of terephthalic acid dimethyl ester | |
| ES8506630A1 (en) | Process for the preparation of 6-methyl-nicotinic-acid esters. | |
| GB768893A (en) | Process for the production of methyl bromide | |
| GB810165A (en) | Process for the preparation of lactams |