GB809295A - Improvements in or relating to parasiticidal drugs - Google Patents

Improvements in or relating to parasiticidal drugs

Info

Publication number
GB809295A
GB809295A GB960056A GB960056A GB809295A GB 809295 A GB809295 A GB 809295A GB 960056 A GB960056 A GB 960056A GB 960056 A GB960056 A GB 960056A GB 809295 A GB809295 A GB 809295A
Authority
GB
United Kingdom
Prior art keywords
amino
salt
suramin
quaternary
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB960056A
Inventor
James Williamson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
National Research Development Corp UK
Original Assignee
National Research Development Corp UK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by National Research Development Corp UK filed Critical National Research Development Corp UK
Publication of GB809295A publication Critical patent/GB809295A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/32—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of salts of sulfonic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/45—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton
    • C07C309/51—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/10—Aza-phenanthrenes
    • C07D221/12—Phenanthridines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention comprises complexes of the hexa-sodium salt of 3 : 3-ureido-bis-[8-(3-benzamido - p - toluoylamino) 1 : 3 : 5 - naphthalene trisulphonic acid] (suramin) and a basic trypanocidal drug which is a quaternary salt chosen from 4 - amino - 6 - (21 - amino - 61-methylpyrimidyl - 41 - amino) quinaldine - 1 : 11-dimethyl sulphate (I), 2 : 7-diamino-9-phenyl-10 - ethyl - phenanthridinium bromide (II), a salt of 2 - amino - 7 - (21 - amino - 11 : 61 - dimethyl - pyrimidyl - 41 - amino) - 9 - p - aminophenyl - 10 - methylphenanthridine (III), or a salt of 2 - amino - 7 - (21 - amine - 11 : 61 - dimethylpyrimidyl - 41 - amino) 9 - phenyl - 10-ethylphenanthridine (IV). The complexes are made by adding an aqueous solution of suramin to an aqueous solution of the trypanocidal drug the molecular proportions suramin : trypanocidal drug being 1 : 6 in the case of the mono-quaternary compound I(I) and 1 : 3 in the case of the di quaternary compounds (I), (III) and (IV). The products are used in the treatment of trypanosomiasis.
GB960056A 1958-01-20 1956-03-27 Improvements in or relating to parasiticidal drugs Expired GB809295A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB187558A GB852650A (en) 1958-01-20 1958-01-20 Improvements in or relating to parasiticidal drugs

Publications (1)

Publication Number Publication Date
GB809295A true GB809295A (en) 1959-02-18

Family

ID=9729565

Family Applications (2)

Application Number Title Priority Date Filing Date
GB960056A Expired GB809295A (en) 1958-01-20 1956-03-27 Improvements in or relating to parasiticidal drugs
GB187558A Expired GB852650A (en) 1958-01-20 1958-01-20 Improvements in or relating to parasiticidal drugs

Family Applications After (1)

Application Number Title Priority Date Filing Date
GB187558A Expired GB852650A (en) 1958-01-20 1958-01-20 Improvements in or relating to parasiticidal drugs

Country Status (4)

Country Link
CH (1) CH364786A (en)
DE (1) DE1083826B (en)
FR (2) FR1283806A (en)
GB (2) GB809295A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3305329A1 (en) * 1983-02-17 1984-08-23 Hoechst Ag, 6230 Frankfurt POLYCYCLIC BISAMIDINES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS CHEMOTHERAPEUTICS

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1050956A (en) * 1952-02-20 1954-01-12 Rhone Poulenc Sa Novel salt of di (4'-amidinophenoxy) 1,5 pentane and its preparation process

Also Published As

Publication number Publication date
DE1083826B (en) 1960-06-23
FR87952E (en) 1966-04-29
FR1283806A (en) 1962-02-09
CH364786A (en) 1962-10-15
GB852650A (en) 1960-10-26

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