GB809295A - Improvements in or relating to parasiticidal drugs - Google Patents
Improvements in or relating to parasiticidal drugsInfo
- Publication number
- GB809295A GB809295A GB960056A GB960056A GB809295A GB 809295 A GB809295 A GB 809295A GB 960056 A GB960056 A GB 960056A GB 960056 A GB960056 A GB 960056A GB 809295 A GB809295 A GB 809295A
- Authority
- GB
- United Kingdom
- Prior art keywords
- amino
- salt
- suramin
- quaternary
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/32—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of salts of sulfonic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/45—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton
- C07C309/51—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/10—Aza-phenanthrenes
- C07D221/12—Phenanthridines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention comprises complexes of the hexa-sodium salt of 3 : 3-ureido-bis-[8-(3-benzamido - p - toluoylamino) 1 : 3 : 5 - naphthalene trisulphonic acid] (suramin) and a basic trypanocidal drug which is a quaternary salt chosen from 4 - amino - 6 - (21 - amino - 61-methylpyrimidyl - 41 - amino) quinaldine - 1 : 11-dimethyl sulphate (I), 2 : 7-diamino-9-phenyl-10 - ethyl - phenanthridinium bromide (II), a salt of 2 - amino - 7 - (21 - amino - 11 : 61 - dimethyl - pyrimidyl - 41 - amino) - 9 - p - aminophenyl - 10 - methylphenanthridine (III), or a salt of 2 - amino - 7 - (21 - amine - 11 : 61 - dimethylpyrimidyl - 41 - amino) 9 - phenyl - 10-ethylphenanthridine (IV). The complexes are made by adding an aqueous solution of suramin to an aqueous solution of the trypanocidal drug the molecular proportions suramin : trypanocidal drug being 1 : 6 in the case of the mono-quaternary compound I(I) and 1 : 3 in the case of the di quaternary compounds (I), (III) and (IV). The products are used in the treatment of trypanosomiasis.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB187558A GB852650A (en) | 1958-01-20 | 1958-01-20 | Improvements in or relating to parasiticidal drugs |
Publications (1)
Publication Number | Publication Date |
---|---|
GB809295A true GB809295A (en) | 1959-02-18 |
Family
ID=9729565
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB960056A Expired GB809295A (en) | 1958-01-20 | 1956-03-27 | Improvements in or relating to parasiticidal drugs |
GB187558A Expired GB852650A (en) | 1958-01-20 | 1958-01-20 | Improvements in or relating to parasiticidal drugs |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB187558A Expired GB852650A (en) | 1958-01-20 | 1958-01-20 | Improvements in or relating to parasiticidal drugs |
Country Status (4)
Country | Link |
---|---|
CH (1) | CH364786A (en) |
DE (1) | DE1083826B (en) |
FR (2) | FR1283806A (en) |
GB (2) | GB809295A (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3305329A1 (en) * | 1983-02-17 | 1984-08-23 | Hoechst Ag, 6230 Frankfurt | POLYCYCLIC BISAMIDINES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS CHEMOTHERAPEUTICS |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1050956A (en) * | 1952-02-20 | 1954-01-12 | Rhone Poulenc Sa | Novel salt of di (4'-amidinophenoxy) 1,5 pentane and its preparation process |
-
1956
- 1956-03-27 GB GB960056A patent/GB809295A/en not_active Expired
-
1957
- 1957-03-22 DE DE1957N0013449 patent/DE1083826B/en active Pending
- 1957-03-26 FR FR734870A patent/FR1283806A/en not_active Expired
-
1958
- 1958-01-20 GB GB187558A patent/GB852650A/en not_active Expired
-
1959
- 1959-01-19 CH CH6848259A patent/CH364786A/en unknown
- 1959-01-19 FR FR784341A patent/FR87952E/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
CH364786A (en) | 1962-10-15 |
FR1283806A (en) | 1962-02-09 |
DE1083826B (en) | 1960-06-23 |
FR87952E (en) | 1966-04-29 |
GB852650A (en) | 1960-10-26 |
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