GB796145A - New derivative of precalciferol and process for its production - Google Patents

New derivative of precalciferol and process for its production

Info

Publication number
GB796145A
GB796145A GB24934/57A GB2493457A GB796145A GB 796145 A GB796145 A GB 796145A GB 24934/57 A GB24934/57 A GB 24934/57A GB 2493457 A GB2493457 A GB 2493457A GB 796145 A GB796145 A GB 796145A
Authority
GB
United Kingdom
Prior art keywords
dinitrobenzoate
monoepoxyprecalciferol
dihydroprecalciferol
dihydroxy
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB24934/57A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Publication of GB796145A publication Critical patent/GB796145A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14—All rings being cycloaliphatic
    • C07C2602/24—All rings being cycloaliphatic the ring system containing nine carbon atoms, e.g. perhydroindane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The invention comprises the 3,5-dinitrobenzoate of monoepoxycalciferol having a m.p. of 148-149 DEG C., monoepoxycalciferol having a m.p. of 109-110 DEG C. and a process for the production of the 3,5-dinitrobenzoate of monoepoxyprecalciferol, characterized in that precalciferol dinitrobenzoate dissolved in a solvent therefore which is immiscible with water, e.g. ether, is oxidized with an organic peracid, e.g. perphthalic acid at a temperature comprised between - 10 DEG and + 10 DEG C. so as to produce the 3,5-dinitrobenzoate of monoepoxyprecalciferol. Preferably the starting material is dissolved in ether and the reaction effected with perphthalic acid between - 5 DEG to + 5 DEG C. Subsequently the 3,5-dinitrobenzoate may be saponified in an inert solvent, e.g. ether with a solution of potassium hydroxide in methanol to obtain the 3,5-dinitrobenzoate of monoepoxyprecalciferol, or hydrolysed using aqueous sulphuric acid to obtain the 3,5-dinitrobenzoate of dihydroxy-dihydroprecalciferol which in turn yields dihydroxy - dihydroprecalciferol with potassium hydroxide in methanol. In an example, the production of monoepoxyprecalciferol and the 3,5-dinitrobenzoate are described and also the subsequent conversion of the 3,5-dinitrobenzoate to the dinitrobenzoate of dihydroxy-dihydroprecalciferol and to dihydroxy - dihydroprecalciferol. Specification 668,114 is referred to.
GB24934/57A 1955-05-13 1956-05-09 New derivative of precalciferol and process for its production Expired GB796145A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR796145X 1955-05-13

Publications (1)

Publication Number Publication Date
GB796145A true GB796145A (en) 1958-06-04

Family

ID=9235005

Family Applications (1)

Application Number Title Priority Date Filing Date
GB24934/57A Expired GB796145A (en) 1955-05-13 1956-05-09 New derivative of precalciferol and process for its production

Country Status (1)

Country Link
GB (1) GB796145A (en)

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