GB786761A - Improvements in and relating to the preparation of intermediates in the synthesis ofpyrimidine compounds - Google Patents
Improvements in and relating to the preparation of intermediates in the synthesis ofpyrimidine compoundsInfo
- Publication number
- GB786761A GB786761A GB704655A GB704655A GB786761A GB 786761 A GB786761 A GB 786761A GB 704655 A GB704655 A GB 704655A GB 704655 A GB704655 A GB 704655A GB 786761 A GB786761 A GB 786761A
- Authority
- GB
- United Kingdom
- Prior art keywords
- water
- dioxan
- guanidine
- chlorophenyl
- benzene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
b -Methoxy-b -ethyl-a -p-chlorophenylacrylonitrile is prepared by reacting a -p-chlorophenyl-b -ketovaleronitrile with methyl sulphate in the presence of an alkali metal bicarbonate in a solvent consisting of a major part of dioxan and a minor part of water. Preferably the reaction is carried out with heating, using 2-4 equivalents of methyl sulphate, 3-5 equivalents of alkali metal bicarbonate and dioxan containing 5-15 per cent by volume of water. The reaction mixture may be worked up by adding water and toluene or benzene, withdrawing the aqueous layer containing salts, and distilling off the toluene or benzene to dry the non-aqueous layer, which can be employed directly for condensation with guanidine to produce 2 : 4-diamino-5-p-chlorophenyl-6-ethylpyrimidine. An example illustrates the preferred procedure, using sodium bicarbonate and dioxan containing 10 per cent by volume of water, and carrying out the final condensation with guanidine in ethanolic solution. Specifications 715,813 and 716,190 are referred to.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB704655A GB786761A (en) | 1955-03-10 | 1955-03-10 | Improvements in and relating to the preparation of intermediates in the synthesis ofpyrimidine compounds |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB704655A GB786761A (en) | 1955-03-10 | 1955-03-10 | Improvements in and relating to the preparation of intermediates in the synthesis ofpyrimidine compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB786761A true GB786761A (en) | 1957-11-27 |
Family
ID=9825601
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB704655A Expired GB786761A (en) | 1955-03-10 | 1955-03-10 | Improvements in and relating to the preparation of intermediates in the synthesis ofpyrimidine compounds |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB786761A (en) |
-
1955
- 1955-03-10 GB GB704655A patent/GB786761A/en not_active Expired
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