GB781418A - New sulfonamides - Google Patents
New sulfonamidesInfo
- Publication number
- GB781418A GB781418A GB6596/56A GB659656A GB781418A GB 781418 A GB781418 A GB 781418A GB 6596/56 A GB6596/56 A GB 6596/56A GB 659656 A GB659656 A GB 659656A GB 781418 A GB781418 A GB 781418A
- Authority
- GB
- United Kingdom
- Prior art keywords
- acetylimino
- thiadiazoline
- methyl
- propionylimino
- benzylmercapto
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Abstract
The invention comprises 5-acylimino-4-substituted - D 2 - 1:3:4 - thiadiazoline - 2 - sulphonamides of the formula <FORM:0781418/IV (a)/1> wherein R1 is hydrogen, an alkyl group of 1-6 carbon atoms or a monocyclic aralkyl group and R2 is an alkyl group of 1-6 carbon atoms or a monocyclic aralkyl group. The compounds are made by reacting a 5-acylamino-4 - substituted - 2 - benzylmercapto - D 2 - 1:3:4-thiadiazoline with chlorine, for example by passing chlorine gas through a suspension or solution of the thiadiazoline in aqueous acid, such as 10 per cent aqueous acetic acid, and treating the resulting sulphonyl chloride with ammonia to give the desired sulphonamide. Examples describe the preparation by the above methods of 5 - acetylimino - 4 - benzyl -, 5-acetylimino - 4 - ethyl -, 5 - propionylimino-4 - methyl -, 5 - propionylimino - 4 - ethyl - and 5 - acetylimino - 4 - methyl -, D 2 - 1:3:4-thiadiazoline - 2 - sulphonamides; by similar methods the corresponding 5-formylimino-4-methyl -, 5 - butyrylimino - 4 - methyl -, 5-butyrylimino - 4 - benzyl -, 5 - acetylimino - 4-butyl - and 5 - propionylimino - 4 - butyl derivatives may be prepared. Starting materials. The 5-acylimino-4-substituted - 2 - benzylmercapto - D 2 - 1:3:4-thiadiazolines used as starting materials may be prepared by alkylating or aralkylating the corresponding 2 - acylamino - 5 - benzylmercapto-1:3:4-thiadiazoles with an alkyl or aralkyl halide, preferably in the presence of a sodium alkoxide. Specification 687,760 is is referred to.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US781418XA | 1955-03-04 | 1955-03-04 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB781418A true GB781418A (en) | 1957-08-21 |
Family
ID=22142173
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB6596/56A Expired GB781418A (en) | 1955-03-04 | 1956-03-02 | New sulfonamides |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB781418A (en) |
-
1956
- 1956-03-02 GB GB6596/56A patent/GB781418A/en not_active Expired
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