GB781418A - New sulfonamides - Google Patents

New sulfonamides

Info

Publication number
GB781418A
GB781418A GB6596/56A GB659656A GB781418A GB 781418 A GB781418 A GB 781418A GB 6596/56 A GB6596/56 A GB 6596/56A GB 659656 A GB659656 A GB 659656A GB 781418 A GB781418 A GB 781418A
Authority
GB
United Kingdom
Prior art keywords
acetylimino
thiadiazoline
methyl
propionylimino
benzylmercapto
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB6596/56A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of GB781418A publication Critical patent/GB781418A/en
Expired legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)

Abstract

The invention comprises 5-acylimino-4-substituted - D 2 - 1:3:4 - thiadiazoline - 2 - sulphonamides of the formula <FORM:0781418/IV (a)/1> wherein R1 is hydrogen, an alkyl group of 1-6 carbon atoms or a monocyclic aralkyl group and R2 is an alkyl group of 1-6 carbon atoms or a monocyclic aralkyl group. The compounds are made by reacting a 5-acylamino-4 - substituted - 2 - benzylmercapto - D 2 - 1:3:4-thiadiazoline with chlorine, for example by passing chlorine gas through a suspension or solution of the thiadiazoline in aqueous acid, such as 10 per cent aqueous acetic acid, and treating the resulting sulphonyl chloride with ammonia to give the desired sulphonamide. Examples describe the preparation by the above methods of 5 - acetylimino - 4 - benzyl -, 5-acetylimino - 4 - ethyl -, 5 - propionylimino-4 - methyl -, 5 - propionylimino - 4 - ethyl - and 5 - acetylimino - 4 - methyl -, D 2 - 1:3:4-thiadiazoline - 2 - sulphonamides; by similar methods the corresponding 5-formylimino-4-methyl -, 5 - butyrylimino - 4 - methyl -, 5-butyrylimino - 4 - benzyl -, 5 - acetylimino - 4-butyl - and 5 - propionylimino - 4 - butyl derivatives may be prepared. Starting materials. The 5-acylimino-4-substituted - 2 - benzylmercapto - D 2 - 1:3:4-thiadiazolines used as starting materials may be prepared by alkylating or aralkylating the corresponding 2 - acylamino - 5 - benzylmercapto-1:3:4-thiadiazoles with an alkyl or aralkyl halide, preferably in the presence of a sodium alkoxide. Specification 687,760 is is referred to.
GB6596/56A 1955-03-04 1956-03-02 New sulfonamides Expired GB781418A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US781418XA 1955-03-04 1955-03-04

Publications (1)

Publication Number Publication Date
GB781418A true GB781418A (en) 1957-08-21

Family

ID=22142173

Family Applications (1)

Application Number Title Priority Date Filing Date
GB6596/56A Expired GB781418A (en) 1955-03-04 1956-03-02 New sulfonamides

Country Status (1)

Country Link
GB (1) GB781418A (en)

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