GB767153A - Stable penicillin suspensions for oral therapeutic use - Google Patents

Stable penicillin suspensions for oral therapeutic use

Info

Publication number
GB767153A
GB767153A GB2420454A GB2420454A GB767153A GB 767153 A GB767153 A GB 767153A GB 2420454 A GB2420454 A GB 2420454A GB 2420454 A GB2420454 A GB 2420454A GB 767153 A GB767153 A GB 767153A
Authority
GB
United Kingdom
Prior art keywords
per cent
penicillin
gum
composition
list
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2420454A
Inventor
Frank Harold Buckwalter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Laboratories Inc
Original Assignee
Bristol Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Laboratories Inc filed Critical Bristol Laboratories Inc
Priority to GB2420454A priority Critical patent/GB767153A/en
Publication of GB767153A publication Critical patent/GB767153A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A stable suspension for oral use comprises a therapeutic salt of penicillin and coconut oil substantially free from tristearin which may be gelled with from 0.1 to 10.0 per cent by weight of the coconut oil of aluminium mono-, di- or tri-, stearate. The particles of the penicillin salt may be coated with 0.1 to 6.0 per cent of a hydrophillic gum-like colloid insoluble in oil, e.g. kelmar, gum acacia, gum karaya, gum tragacanth, polyvinylpyrrolione, methyl cellulose or sodium carboxymethylcellulose. The composition may contain up to about 20 per cent of mineral oil, edible or injectable oils or non-toxic fatty acid esters, e.g. butyl stearate, isopropyl myristate, from 1.0 to 10.0 per cent of fillers e.g. talc, kaolin, calcium carbonate, or aluminium hydroxide, and from 0.01 to 2 per cent surface active agents, e.g. amerchols, lecithin, polyoxalkylenesorbitals, "Spans" (Registered Trade Mark) "Tweans" (Registered Trade Mark). Sulphonamides of which a list is given, may also be incorporated in the composition. The Specification contains a list of the penicillin salts which may be used in the composition according to the invention. Specification 613,524 is referred to.
GB2420454A 1954-08-19 1954-08-19 Stable penicillin suspensions for oral therapeutic use Expired GB767153A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB2420454A GB767153A (en) 1954-08-19 1954-08-19 Stable penicillin suspensions for oral therapeutic use

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2420454A GB767153A (en) 1954-08-19 1954-08-19 Stable penicillin suspensions for oral therapeutic use

Publications (1)

Publication Number Publication Date
GB767153A true GB767153A (en) 1957-01-30

Family

ID=10208019

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2420454A Expired GB767153A (en) 1954-08-19 1954-08-19 Stable penicillin suspensions for oral therapeutic use

Country Status (1)

Country Link
GB (1) GB767153A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3121044A (en) * 1960-10-06 1964-02-11 Beecham Res Lab Three-layer compressed penicillin tablet
WO2008039472A2 (en) * 2006-09-26 2008-04-03 Taro Pharmaceuticals North America, Inc. Stabilizing compositions for antibiotics and methods of use

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3121044A (en) * 1960-10-06 1964-02-11 Beecham Res Lab Three-layer compressed penicillin tablet
WO2008039472A2 (en) * 2006-09-26 2008-04-03 Taro Pharmaceuticals North America, Inc. Stabilizing compositions for antibiotics and methods of use
WO2008039472A3 (en) * 2006-09-26 2008-11-27 Taro Pharmaceuticals Usa Inc Stabilizing compositions for antibiotics and methods of use
US8106040B2 (en) 2006-09-26 2012-01-31 Taro Pharmaceuticals North America, Inc. Stabilizing compositions for antibiotics and methods of use
US8461143B2 (en) 2006-09-26 2013-06-11 Taro Pharmaceuticals North America, Inc. Stabilizing compositions for antibiotics and methods of use

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