GB766993A - Improvements in or relating to the production of heparin - Google Patents
Improvements in or relating to the production of heparinInfo
- Publication number
- GB766993A GB766993A GB498755A GB498755A GB766993A GB 766993 A GB766993 A GB 766993A GB 498755 A GB498755 A GB 498755A GB 498755 A GB498755 A GB 498755A GB 766993 A GB766993 A GB 766993A
- Authority
- GB
- United Kingdom
- Prior art keywords
- salt
- heparin
- solution
- range
- treated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
Abstract
An alkali metal heparin aqueous salt solution is freed from pyrogens by maintaining an aqueous solution of the heparin salt of a concentration of at least 40 grams per 100 cubic centimetres at a pH within the range of 8.0 to 8.5 and a temperature within the range of 0 DEG to 5 DEG C. for a period of at least 48 hours, and then separating the solution of the heparin salt from the precipitate which forms. The heparin salt may then be isolated from the resulting solution. In the example the sodium salt of heparin is treated by the above process, a small amount of cresol being present in the solution as preservative, and the salt may be isolated from the resulting solution, e.g. by freeze drying or by precipitating the salt by adding an excess of a water-miscible liquid such as alcohol. The process may be applied to a heparin salt which has been decolorized by the process of Specification 766,992.ALSO:An aqueous solution of an alkali metal salt of heparin is freed from pyrogens by maintaining the solution at a concentration of at least 40 grams of salt per 100 cubic centimetres at a pH within the range of 8.0 to 8.5 and at a temperature within the range of 0 DEG to 5 DEG C. for a period of at least 48 hours, and then separating the solution of the heparin salt from the precipitate which forms. The process may be applied to a heparin salt solution which has been treated by the process of Specification 766,992. In the example an aqueous solution of the sodium salt of heparin and containing a small amount of cresol as preservative is treated by the above process.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB498755A GB766993A (en) | 1954-03-19 | 1954-03-19 | Improvements in or relating to the production of heparin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB498755A GB766993A (en) | 1954-03-19 | 1954-03-19 | Improvements in or relating to the production of heparin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB766993A true GB766993A (en) | 1957-01-30 |
Family
ID=9787589
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB498755A Expired GB766993A (en) | 1954-03-19 | 1954-03-19 | Improvements in or relating to the production of heparin |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB766993A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103145876A (en) * | 2012-12-08 | 2013-06-12 | 青岛九龙生物医药有限公司 | Method of reducing ethanol residue in heparin sodium |
-
1954
- 1954-03-19 GB GB498755A patent/GB766993A/en not_active Expired
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103145876A (en) * | 2012-12-08 | 2013-06-12 | 青岛九龙生物医药有限公司 | Method of reducing ethanol residue in heparin sodium |
| CN103145876B (en) * | 2012-12-08 | 2015-11-25 | 青岛九龙生物医药有限公司 | A kind of method reducing alcohol residue in heparin sodium |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB766993A (en) | Improvements in or relating to the production of heparin | |
| GB840206A (en) | A process for the treatment of artificial sponges of regenerated cellulose, to prevent attack by bacteria and fungi and the sponges thus treated | |
| GB748024A (en) | Improved therapeutic preparations of iron | |
| GB858783A (en) | Improvements in or relating to vitamin b compositions | |
| GB722586A (en) | Process for fractionating starch | |
| ES269965A1 (en) | Process for removal of radionuclides from milk | |
| GB838916A (en) | Improvements in the preparation of titanium | |
| SU107073A1 (en) | Method for increasing corrosion resistance of sulfided products | |
| GB581944A (en) | Production of lithium hypochlorite | |
| GB782715A (en) | Process for the preparation of lead azide | |
| GB769211A (en) | Process for fractionating starch | |
| GB887012A (en) | Process for the preparation of 18ª--glycyrrhetinic acid | |
| GB1001704A (en) | Process for the production of water soluble derivatives of ªÐ-amino-salicylic acid | |
| NL32365C (en) | ||
| GB816592A (en) | A method for the preparation of stable magnesium solutions of high concentration | |
| GB816236A (en) | Improvements in the preparation of phenanthridine compounds | |
| GB1173400A (en) | A Process for Preparing 1-methyl-2, 3, 5, 6-tetrahydro-5-semicarbazido-6-hydroxy-indole-3-sulphonic acid and alkali metal salts thereof | |
| GB822667A (en) | Process for the preparation of common salt by the evaporation of solutions | |
| GB795424A (en) | Improvements in or relating to sodium cyanide | |
| GB927423A (en) | Dipiperazine sulphate solutions and method therefor | |
| GB841635A (en) | Process for the production of 5-nitro-2-furfuraldehyde semicarbazone | |
| GB922378A (en) | Thiolo- and selenolo-phosphoric, -thionophosphoric, -phosphonic and -thionophosphonic acid esters | |
| GB794294A (en) | Process for the production of oxalate coatings on ferrous metals | |
| GB772966A (en) | Preparation of 2,4,5-trichlorophenoxyacetic acid | |
| GB798782A (en) | Anhydrous sterile preparations of alkali barbiturates and alkali thiobarbiturates |